Multiple Sulfatase Deficiency (MSD): Review of the Literature and Case Reports of Two Siblings with Dental Caries and Trauma [PDF]
Case Reports in Pediatrics, 2021 Multiple sulfatase deficiency (MSD) (MIM # 272200) is an extraordinarily rare inborn error of metabolism (IEM). The phenotypic spectrum is largely heterogeneous and attributed to the combined effects of deficiencies in the nine sulfatases currently known
Lorna Hirst +2 more
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Bone marrow transplantation reverses metabolic alterations in multiple sulfatase deficiency: a case series [PDF]
Communications MedicineBackground Multiple sulfatase deficiency (MSD) is an exceptionally rare neurodegenerative disorder due to the absence or deficiency of 17 known cellular sulfatases.
Nishitha R. Pillai +12 more
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Identification and Signature Sequences of Bacterial Δ4,5Hexuronate-2-O-Sulfatases
Frontiers in Microbiology, 2019 Glycosaminoglycan (GAG) sulfatases, which catalyze the hydrolysis of sulfate esters from GAGs, belong to a large and conserved sulfatase family. Bacterial GAG sulfatases are essential in the process of sulfur cycling and are useful for the structural ...
Shumin Wang +4 more
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Sulfatase 2 inhibition sensitizes triple-negative breast cancer cells to paclitaxel through augmentation of extracellular ATP [PDF]
Cancer Biology & TherapyThe highest incidence and cancer-related mortality rate among women worldwide is due to breast cancer. Triple-negative breast cancers (TNBC) are associated with more inferior outcomes than other breast cancers because of their progressive nature and the ...
Jasmine M. Manouchehri +12 more
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Sulfatase modifying factor 2 as a predictive biomarker for urothelial carcinoma [PDF]
Discover OncologySulfatases mediate the sulfation level of cell-surface heparan sulfates to regulate signal transduction, thereby promoting cancer progression. Sulfatase activation requires a sulfatase modifying factor (SUMF) for the modification of its catalytic domain.
Wei-Ting Kuo +4 more
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Bone marrow transplantation increases sulfatase activity in somatic tissues in a multiple sulfatase deficiency mouse model [PDF]
Communications MedicineBackground Multiple Sulfatase Deficiency (MSD) is an ultra-rare autosomal recessive disorder characterized by deficient enzymatic activity of all known sulfatases. MSD patients frequently carry two loss of function mutations in the SUMF1 gene, encoding a
Maximiliano Presa +10 more
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Sulfatases: Critical Enzymes for Algal Polysaccharide Processing
Frontiers in Plant Science, 2022 Microbial sulfatases are important biocatalysts in the marine environment where they play a key role in the catabolic biotransformation of abundant sulphated algal polysaccharides. The sulphate esters decorating algal polysaccharides, such as carrageenan,
Andrew G. Hettle +2 more
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The Role of Sulfation in Nematode Development and Phenotypic Plasticity
Frontiers in Molecular Biosciences, 2022 Sulfation is poorly understood in most invertebrates and a potential role of sulfation in the regulation of developmental and physiological processes of these organisms remains unclear. Also, animal model system approaches did not identify many sulfation-
Catia Igreja, Ralf J. Sommer
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Matching the Diversity of Sulfated Biomolecules: Creation of a Classification Database for Sulfatases Reflecting Their Substrate Specificity. [PDF]
PLoS ONE, 2016 Sulfatases cleave sulfate groups from various molecules and constitute a biologically and industrially important group of enzymes. However, the number of sulfatases whose substrate has been characterized is limited in comparison to the huge diversity of ...
Tristan Barbeyron +7 more
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Frontiers in Microbiology, 2022 Chondroitin sulfate (CS)/dermatan sulfate (DS) is a kind of sulfated polyanionic, linear polysaccharide belonging to glycosaminoglycan. CS/DS sulfatases, which specifically hydrolyze sulfate groups from CS/DS oligo-/polysaccharides, are potential tools ...
Lin Wei +10 more
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