Sulfatases: Critical Enzymes for Algal Polysaccharide Processing
Frontiers in Plant Science, 2022 Microbial sulfatases are important biocatalysts in the marine environment where they play a key role in the catabolic biotransformation of abundant sulphated algal polysaccharides. The sulphate esters decorating algal polysaccharides, such as carrageenan,
Andrew G. Hettle +2 more
doaj +2 more sources
Multiple Sulfatase Deficiency [PDF]
Neurology, 1988 Multiple sulfatase deficiency is an inherited disorder characterized by a deficiency of several sulfatases and the accumulation of sulfatides, glycosaminoglycans, sphingolipids, and steroid sulfates in tissues and body fluids. The clinical manifestations represent the summation of two diseases: late infantile metachromatic leukodystrophy and ...
J Gordon Millichap
openalex +3 more sources
Human Sulfatase 2 inhibits
BMC Cancer, 2010 Background Extracellular human sulfatases modulate growth factor signaling by alteration of the heparin/heparan sulfate proteoglycan (HSPG) 6-O-sulfation state.
Peterson Sarah M +11 more
doaj +4 more sources
Late infantile form of multiple sulfatase deficiency with a novel missense variant in the SUMF1 gene: case report and review [PDF]
BMC Pediatrics, 2023 Background Multiple sulfatase deficiency (MSD) is a rare lysosomal storage disorder caused due to pathogenic variants in the SUMF1 gene. The SUMF1 gene encodes for formylglycine generating enzyme (FGE) that is involved in the catalytic activation of the ...
Jayesh Sheth +9 more
doaj +2 more sources
Detection of bacterial sulfatase activity through liquid- and solid-phase colony-based assays [PDF]
AMB Express, 2017 Bacterial arylsulfatases are crucial to biosynthesis in many microorganisms, as bacteria often utilize aryl sulfates as a source of sulfur. The bacterial sulfatases are associated with pathogenesis and are applied in many areas such as industry and ...
Hey Young Yoon +3 more
doaj +2 more sources
Bone marrow transplantation reverses metabolic alterations in multiple sulfatase deficiency: a case series [PDF]
Communications MedicineBackground Multiple sulfatase deficiency (MSD) is an exceptionally rare neurodegenerative disorder due to the absence or deficiency of 17 known cellular sulfatases.
Nishitha R. Pillai +12 more
doaj +2 more sources
Preparation and purification of Flavobacterium heparinum chondroitinases AC and B by hydrophobic interaction chromatography [PDF]
Brazilian Journal of Medical and Biological Research, 1999 Flavobacterium heparinum is a soil bacterium that produces several mucopolysaccharidases such as heparinase, heparitinases I and II, and chondroitinases AC, B, C and ABC. The purpose of the present study was to optimize the preparation of F.
J.A.K. Aguiar, Y.M. Michelacci
doaj +2 more sources
Sulfatase 2 inhibition sensitizes triple-negative breast cancer cells to paclitaxel through augmentation of extracellular ATP [PDF]
Cancer Biology & TherapyThe highest incidence and cancer-related mortality rate among women worldwide is due to breast cancer. Triple-negative breast cancers (TNBC) are associated with more inferior outcomes than other breast cancers because of their progressive nature and the ...
Jasmine M. Manouchehri +12 more
doaj +2 more sources
Sulfatase modifying factor 2 as a predictive biomarker for urothelial carcinoma [PDF]
Discover OncologySulfatases mediate the sulfation level of cell-surface heparan sulfates to regulate signal transduction, thereby promoting cancer progression. Sulfatase activation requires a sulfatase modifying factor (SUMF) for the modification of its catalytic domain.
Wei-Ting Kuo +4 more
doaj +2 more sources
Bone marrow transplantation increases sulfatase activity in somatic tissues in a multiple sulfatase deficiency mouse model [PDF]
Communications MedicineBackground Multiple Sulfatase Deficiency (MSD) is an ultra-rare autosomal recessive disorder characterized by deficient enzymatic activity of all known sulfatases. MSD patients frequently carry two loss of function mutations in the SUMF1 gene, encoding a
Maximiliano Presa +10 more
doaj +2 more sources