Results 51 to 60 of about 917 (187)

Specific sulfation and glycosylation - a structural combination for the anticoagulation of marine carbohydrates

Frontiers in Cellular and Infection Microbiology, 2014
Based on considered achievements of the last 25 years, specific combinations of sulfation patterns and glycosylation types have been proved to be key structural players for the anticoagulant activity of certain marine glycans.
Vitor Hugo Pomin, Paulo Antonio De Souza Mourão   +1 more
doaj   +1 more source

Anticoagulant properties of a crude sulfated polysaccharide from the red marine alga Halymenia floresia (Clemente) C. Agardh - doi: 10.4025/actascibiolsci.v33i3.6402

Acta Scientiarum: Biological Sciences, 2011
Alternative sources of anticoagulants have arisen as a result of the increasing demand for safer anticoagulant clinical therapy, and the sulfated polysaccharides of seaweeds have gained attention in biomedicine.
Rodrigo César das Neves Amorim, José Ariévilo Gurgel Rodrigues, Márjory Lima Holanda, Paulo Antônio de Souza Mourão, Norma Maria Barros Benevides   +4 more
doaj   +1 more source

Sulfated Polysaccharide Extracted from the Green Algae Codium bernabei: Physicochemical Characterization and Antioxidant, Anticoagulant and Antitumor Activity

Marine Drugs, 2022
Codium bernabei is a green alga that grows on Chilean coasts. The composition of its structural polysaccharides is still unknown. Hence, the aim of this work is to isolate and characterize the hot water extracted polysaccharide fractions.
Fabian A. Figueroa, Roberto T. Abdala-Díaz, Claudia Pérez, Virginia Casas-Arrojo, Aleksandra Nesic, Cecilia Tapia, Carla Durán, Oscar Valdes, Carolina Parra, Gastón Bravo-Arrepol, Luis Soto, José Becerra, Gustavo Cabrera-Barjas   +12 more
doaj   +1 more source

Sulfated galactans from red seaweed Gracilaria fisheri target epidermal growth factor receptor (EGFR) and inhibit cholangiocarcinoma cells (CCA) proliferation [PDF]

, 2017
Cholangiocarcinoma (CCA) is increasing in incidence worldwide and is resistant to chemotherapeutic agents, making treatment of CCA a major challenge. Previous studies reported that natural sulfated polysaccharides (SPs) disrupted growth factor receptor ...
Wongprasert, Kanokpan, Bates, David O., Thannicha Sae-Lao, Tohtong, Rutaiwan, Kanokpan Wongprasert, Rutaiwan Tohtong, Sae-lao, Thannich, David O. Bates   +7 more
core   +1 more source

Isolation of Sulfated Galactan from Codium fragile and Its Antiviral Effect

Biological and Pharmaceutical Bulletin, 2009
A sulfated galactan (FG) was isolated from the green alga, Codium fragile. Chemical analysis revealed that FG mainly consisted of D-galactose with pyruvic acid (12.3%) and sulfate (11.0%). Methylation and NMR analyses showed that FG was composed of -->3)-beta-D-Galp-(1-->, beta-D-Galp-(1--> and -->3,6)-beta-D-Galp-(1--> residue.
Ohta, Yuko, Lee, Jung-Bum, Hayashi, Kyoko, Hayashi, Toshimitsu   +3 more
openaire   +3 more sources

Dual Effects of Sulfated D-galactans from the Red Algae Botryocladia occidentalis Preventing Thrombosis and Inducing Platelet Aggregation

, 2001
SummarySulfated D-galactans occur on the red algae Botryocladia occidentalis as three fractions that differ in their sulfate content. Fractions F2 and F3 are potent anticoagulants.
Wladimir Farias, Paulo Mourão, Rômulo Nazareth   +2 more
core   +1 more source

Antithrombotics from the Sea: Polysaccharides and Beyond

Marine Drugs, 2019
Marine organisms exhibit some advantages as a renewable source of potential drugs, far beyond chemotherapics. Particularly, the number of marine natural products with antithrombotic activity has increased in the last few years, and reports show a wide ...
Francisca Carvalhal, Ricardo R. Cristelo, Diana I. S. P. Resende, Madalena M. M. Pinto, Emília Sousa, Marta Correia-da-Silva   +5 more
doaj   +1 more source

A Novel κ-Carrageenase from Marine Bacterium Rhodopirellula sallentina SM41: Heterologous Expression, Biochemical Characterization and Salt-Tolerance Mechanism Investigation

Marine Drugs, 2022
κ-carrageenases are members of the glycoside hydrolase family 16 (GH16) that hydrolyze sulfated galactans in red algae, known as κ-carrageenans. In this study, a novel κ-carrageenase gene from the marine bacterium Rhodopirellula sallentina SM41 (RsCgk ...
Yong-Hui Zhang, Yi-Ying Chen, Xiao-Yan Zhuang, Qiong Xiao, Jun Chen, Fu-Quan Chen, Qiu-Ming Yang, Hui-Fen Weng, Bai-Shan Fang, An-Feng Xiao   +9 more
doaj   +1 more source

Glyco‐Nanogels for Modulating Pseudomonas aeruginosa Biofilm

Macromolecular Rapid Communications, EarlyView.
Nanogels presenting α‐galactose and β‐fucose can significantly alter Pseudomonas aeruginosa biofilm dynamics through their interaction with lectins. Application timing is crucial: pre‐treatment reduces biofilm, while treatment after biofilm initiation increases biomass.
Sophia Rosencrantz, Jo Sing Julia Tang, Karina Koenig, Sany Chea, Ruben R. Rosencrantz   +4 more
wiley   +1 more source

Charge distribution and calcium affinity of sulfated alpha-L-galactans from ascidians. Comparison between linear and highly branched polymers

, 1998
Calcium binding and charge distribution on highly branched and linear sulfated L-galactans from ascidians have been studied using a metallochromic indicator and conductimetric titrations.
Fossey, Marcelo Andrés [UNESP], Santos, J. A., Paulo A.S Mourão, Janayna A Santos, Fossey, Marcelo Andrés, Marcelo A Fossey, João Ruggiero, Mourao, P. A. S., Ruggiero, J.   +8 more
core   +1 more source