Results 91 to 100 of about 700,714 (339)

Antithrombotics from the Sea: Polysaccharides and Beyond

Marine Drugs, 2019
Marine organisms exhibit some advantages as a renewable source of potential drugs, far beyond chemotherapics. Particularly, the number of marine natural products with antithrombotic activity has increased in the last few years, and reports show a wide ...
Francisca Carvalhal, Ricardo R. Cristelo, Diana I. S. P. Resende, Madalena M. M. Pinto, Emília Sousa, Marta Correia-da-Silva   +5 more
doaj   +1 more source

Antiproliferative activity of fucan nanogel [PDF]

, 2012
Sulfated fucans comprise families of polydisperse natural polysaccharides based on sulfated l-fucose. Our aim was to investigate whether fucan nanogel induces cell-specific responses.
Gama, F. M., Gomes, Dayanne Lopes, Lima, Jailma Almeida, Oliveira, Ruth Medeiros, Pedrosa, Sílvia Santos, Pereira, Paula, Rocha, Hugo Alexandre Oliveira, Santos, Nednaldo Dantas, Vidal, Arthur Anthunes Jacome   +8 more
core   +2 more sources

Stable Protein‐Based G‐Quadruplex‐Derived Supramolecular Bioinks as Tunable ECM‐Mimetic Constructs Assembled by Combining Non‐Covalent and Covalent Strategies

Advanced Materials, EarlyView.
Harnessing the synergistic interplay of supramolecular self‐assembly, under macromolecular crowding conditions, and enzymatic‐mediated covalent crosslinking toward a stable protein‐based G‐quadruplex‐derived supramolecular bioink. This bioinspired strategy enables the biofabrication of complex and tunable ECM‐mimetic constructs, providing a platform ...
Vera Sousa, Rita Sobreiro‐Almeida, Bart W. L. van den Bersselaar, E. W. Meijer, Ghislaine Vantomme, João Borges, João F. Mano   +6 more
wiley   +1 more source

NEUROPROTECTIVE EFFECTS OF SULFATED POLYSACCHARIDES FROM SEAWEED

Annals of the Russian academy of medical sciences, 2013
Currently, neurodegenerative diseases (NDD) occupy a significant place in the structure of disease of the elderly, which dictates the need to find new and effective treatment and prevention of this pathology. At the heart of NDD development is a violation of the metabolism and the conformational change of cellular proteins with subsequent accumulation ...
N N, Besednova, L M, Somova, S A, Guliaev, T S, Zaporozhets   +3 more
openaire   +3 more sources

Conductive Hydrogels for Exogenous Sensing and Cell Fate Control

Advanced Materials, EarlyView.
We engineer electrically conductive hydrogels by combining sulfated glycosaminoglycans with semiconducting polymers. These hydrogels bind bioactive proteins, including growth factors, whose release or retention can be modulated by low‐voltage stimulation. The hydrogels are also integrated as 3D channels in organic electrochemical transistors as part of
Teuku Fawzul Akbar, Carlos Alejandro Jimenez‐Rodriguez, Railia Biktimirova, Ilka Hermes, Thomas Kurth, My Duyen Pham, Mikhail Tsurkan, Jens Friedrichs, Francis L. C. Morgan, Hans Kleemann, Olga Guskova, Uwe Freudenberg, Peter Fratzl, Carsten Werner, Christoph Tondera, Ivan R. Minev   +15 more
wiley   +1 more source

Langerin-Heparin Interaction: Two Binding Sites for Small and Large Ligands as revealed by a combination of NMR Spectroscopy and Cross-Linking Mapping Experiments [PDF]

, 2015
Langerin is a C-type lectin present on Langerhans cells that mediates capture of pathogens in a carbohydrate-dependent manner, leading to subsequent internalization and elimination in the cellular organelles called Birbeck granules.
Angulo, Jesus, Chabrol, Eric, de Paz, José L, Fieschi, Franck, Imberty, Anne, Muñoz-García, Juan C., Nieto, Pedro M., Rojo, Javier, Thomas, Aline, Vives, Romain R.   +9 more
core   +7 more sources

The Role of Ionic Liquids at the Biological Interfaces in Bioelectronics

Advanced Science, EarlyView.
Ionic liquids (ILs) are highlighted as key artificial ionic materials that bridge biological ion‐based signaling and electronic devices. By understanding their composition, structure, function relationships, and mechanisms, ILs can advance from high performance electrolyte to core materials enabling integrated, multifunctional bioelectronics for ...
Yeong‐sinn Ye, Young Jin Jo, Ji Yeon Oh, Ju Yeon Jeong, Lili Guo, Tae‐il Kim   +5 more
wiley   +1 more source

Sulfated modification, characterizations, anti-oxidant and immunostimulatory activities of a polysaccharide from Arnebia euchroma (Royle) Johnst. Roots

Results in Chemistry
Chinese Zicao, also known as A. euchroma (Royle) Johnst., is a valuable agricultural product with roots in traditional Chinese medicine. A polysaccharide was taken from the A. euchroma (Royle) Johnst.
Man Zhang, Peng Zhao, Sarangua Ochir, Wenming Bai, Jingkun Lu, Mu Dan, Surina Bo, Chen Chen   +7 more
doaj   +1 more source

The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids [PDF]

, 2009
The ultraviolet circular dichroism (CD) spectra of commercial low-molecular-weight heparins, heparinoids and other anticoagulant preparations have been recorded between 180 and 260 nm.
Fernig, David G., Guimond, Scott E., Holman, Joseph, Lauder, Robert M., Rudd, Timothy R., Skidmore, Mark A., Turnbull, Jeremy E., Yates, Edwin A.   +7 more
core   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source