Results 71 to 80 of about 13,152 (261)

Anticancer Activity In Vitro of Sulfated Polysaccharides from the Brown Alga Spatoglossum vietnamense

Molecules
Sulfated polysaccharides SpvF1, SpvF2, SpvF3, and SpvF4 from the brown alga S. vietnamense collected north of Hon Do (Nha Trang Bay, Vietnam) were isolated and studied.
Dinh Thanh Trung, Valerii Victorovich Surits, Anastasia Olegovna Zueva, Hang Thi Thuy Cao, Natalia Michailovna Shevchenko, Svetlana Pavlovna Ermakova, Pham Duc Thinh   +6 more
doaj   +1 more source

Design and Engineering of an Artificial Bifunctional N‐Deacetylase/N‐Sulfotransferase for the Biosynthesis of N‐Sulfated Heparosan

Advanced Science, EarlyView.
An artificial bifunctional N‐deacetylase/N‐sulfotransferase was engineered in Escherichia coli by combining screened N‐deacetylases with an NST domain. The integrated engineering strategy improved enzyme performance. The optimized enzyme efficiently converted heparosan into N‐sulfated heparosan, addressing a key bottleneck in microbial heparin ...
Xintong Xi, Ruirui Xu, Daoan Wang, Guobin Yin, Xinjing Wang, Haiqin Chen, Guocheng Du, Jian Chen, Zhen Kang   +8 more
wiley   +1 more source

Heterofucans from the Brown Seaweed Canistrocarpus cervicornis with Anticoagulant and Antioxidant Activities

Marine Drugs, 2011
Fucan is a term used to denominate a family of sulfated polysaccharides rich in sulfated L-fucose. We extracted six fucans from Canistrocarpus cervicornis by proteolytic digestion followed by sequential acetone precipitation.
Hugo Alexandre Oliveira Rocha, Sara Lima Cordeiro, Mariana Santana Santos Pereira Costa, Luciana Guimaraes Alves, Nednaldo Dantas-Santos, Gabriel Pereira Fidelis, Leonardo Thiago Duarte Barreto Nobre, Rafael Barros Gomes Camara, Leandro Silva Costa   +8 more
doaj   +1 more source

Structure and Bioactivity of Sulfated Polysaccharides

Trends in Glycoscience and Glycotechnology, 2003
グリコサミノグリカンを含む酸性多糖類は様々な化学的、生物学的な機能を示す。これらの機能の多くは硫酸基の存在に強く依存している。よってこれら多糖類の部分的硫酸化、完全硫酸化あるいは脱硫酸化などの化学的修飾は、硫酸化多糖の示す機能を制御できるものと期待されている。多糖類の化学的修飾に関する論文は数多く、私たちもこれまで多糖類の化学修飾のみならずその生物学的作用に関して検討してきた(構造-活性相関、SAR)。本論文では天然および化学修飾した多糖類の構造活性相関について最近の結果を示す。
Toida, Toshihiko, Chaidedgumjorn, Amornrut, Linhardt, Robert J.   +2 more
openaire   +2 more sources

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Evaluation of Sulfated Polysaccharides from the Brown Seaweed Dictyopteris Justii as Antioxidant Agents and as Inhibitors of the Formation of Calcium Oxalate Crystals

Molecules, 2013
Oxalate crystals and other types of crystals are the cause of urolithiasis, and these are related to oxidative stress. The search for new compounds with antioxidant qualities and inhibitors of these crystal formations is therefore necessary.
Karoline Rachel Teodosio Melo, Rafael Barros Gomes Camara, Moacir Fernandes Queiroz, Arthur Anthunes Jacome Vidal, Camila Renata Machado Lima, Raniere Fagundes Melo-Silveira, Jailma Almeida-Lima, Hugo Alexandre Oliveira Rocha   +7 more
doaj   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Oral Delivery Systems for Food‐Derived Bioactive Peptides: Enhancing Stability, Bioavailability, and Health Benefits

Advanced Science, EarlyView.
Advanced delivery systems—including nanoparticles, nanoemulsions, liposomes, and hydrogels—protect food‐derived bioactive peptides from gastrointestinal degradation and bitterness. These systems enable pH‐responsive release, enhance intestinal absorption, and improve therapeutic efficacy against oxidative stress, metabolic disorders, cancer, and ...
Yu Xu, Fan Li, Runan Zhao, Tao Shu, Weihong Min, Bei‐Wei Zhu   +5 more
wiley   +1 more source

Robust Stitching Interface and Deep Learning Empowered Hydrogel Human‐Machine Interface

Advanced Science, EarlyView.
A molecular design strategy is presented that exploits synergistic carboxylate anion–quaternary ammonium interactions to simultaneously strengthen the hydrogel–PET interface and the bulk hydrogel network. Integrated with deep learning signal processing, the stable hydrogel–PET interface enables consistent signal acquisition and reliable human‐machine ...
Hao Dong, Yiming Luo, Chuanliu Liu, Mahamood Modupe Rasheedat, Wenjiayi Tan, Fangyu Zhao, Yixue Zhang, Chris Connor, Hua Hou, Hamdy Khamees Thabet, Ben Bin Xu, Huige Wei   +11 more
wiley   +1 more source

Research Progress on Immune Regulation Activities of Marine Sulfate Polysaccharides

Shipin gongye ke-ji
With changes in modern lifestyles, weakened immunity becomes a health problem for an increasing number of people. The development of natural active products with immunomodulatory activity becomes a popular research topic.
Qiuyu CHEN, Ran ZHAO, Meishan MENG, Xinyu DOU, Biyi CHEN, Qiancheng ZHAO, Ying LI   +6 more
doaj   +1 more source