Results 61 to 70 of about 5,159 (209)

Role for Sulfatides in Platelet Aggregation [PDF]

Circulation, 2001
Background — Sulfatides are sulfated glycosphingolipids present on the surface of oligodendrocytes, renal tubular cells, and certain tumor cells. They appear to be involved in nerve conduction and cell adhesion, but
M, Merten, P, Thiagarajan
openaire   +2 more sources

ENT1 inhibition links oligodendrocyte lipid metabolism to connectivity in tauopathy

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Metabolic dysfunction, altered adenosine signaling, and white matter abnormalities are implicated in tauopathies, but their relationship to network disconnection remains unclear. Myelinating oligodendrocytes may represent a metabolically vulnerable hub linking these processes to circuit dysfunction.
Ching‐Pang Chang, Ching‐Wen Chang, Ching‐Wen Wu, Jian Jing Siew, David Blum, Lee‐Way Jin, You‐Yin Chen, Yijuang Chern   +7 more
wiley   +1 more source

Mammalian Expression and Mass Spectrometric Characterization of Highly Active Human Arylsulfatase A

Biotechnology Journal, Volume 21, Issue 9, September 2026.
Graphical Abstract and Lay Summary A method for producing active human aryl sulfatase A by transient transfection of HEK293 cells. Accessory plasmids are included to enhance active site conversion and assist with expression/export. ABSTRACT The lysosomal enzyme Arylsulfatase A (ARSA) plays a critical role in hydrolyzing sulfatides from within cells ...
T. Pal, M. Dabarera, A. Dutta, G. Smolenski, B. D. Dickson, A. Williamson, W. Kelton   +6 more
wiley   +1 more source

Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice

PPAR Research, 2012
Sulfatides are one of the major sphingoglycolipids in mammalian serum and are synthesized and secreted mainly from the liver as a component of lipoproteins.
Takefumi Kimura, Takero Nakajima, Yuji Kamijo, Naoki Tanaka, Lixuan Wang, Atsushi Hara, Eiko Sugiyama, Eiji Tanaka, Frank J. Gonzalez, Toshifumi Aoyama   +9 more
doaj   +1 more source

Ca2+-induced fusion of sulfatide-containing phosphatidylethanolamine small unilamellar vesicles

Journal of Lipid Research, 1999
The fusogenic properties of sulfatide-containing 1,2-dioleoyl-3-sn-phosphatidylethanolamine (DOPE) small unilamellar vesicles (SUVs) in the presence of CaCl2 were studied by mixing membrane lipids based on an assay of fluorescence resonance energy ...
Xiaofeng Wu, Qiu-Tian Li
doaj   +1 more source

Structural basis for sulfatide recognition by Disabled-2

, 2021
Disabled-2 (Dab2) is an adaptor protein that plays critical roles in various biological processes, including protein endocytosis, platelet activation and aggregation, tumor growth, and development. In platelets, Dab2 associates with membrane sulfatide at
Song, Wei
core  

Characterizing Combined Central and Peripheral Demyelination—Insights From a Multimodal Comparison With Chronic Inflammatory Demyelinating Polyneuropathy and Multiple Sclerosis

Muscle &Nerve, Volume 74, Issue 3, Page 605-615, September 2026.
ABSTRACT Introduction/Aims Combined central and peripheral demyelination (CCPD) is a rare dysimmune disorder sharing features with multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Direct comparisons of central and peripheral diagnostic findings across these entities remain limited. We, therefore, performed a
N. Dubuisson, A. Kassab, P. Y. K. Van den Bergh, A. F. J. E. Vrancken, W. L. van der Pol, L. H. van den Berg, H. S. Goedee   +6 more
wiley   +1 more source

Molecular Mediators Associated With Myelination, Demyelination, and Remyelination in the Peripheral Nervous System

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT The peripheral nervous system (PNS) is responsible for innervating all regions of the body outside of the central nervous system (CNS), the latter consisting of the brain, spinal cord, and optic nerves. While myelin is an essential component for the efficient functioning of both CNS and peripheral nerve cells, it is particularly important for ...
Kathleen Margaret Hagen, Shalina Sheryl Ousman   +1 more
wiley   +1 more source

Renally Generated Ammonia as a Cause of Hyperammonaemic Non‐Hepatic Encephalopathy

Nephrology, Volume 31, Issue 9, September 2026.
ABSTRACT Encephalopathy with high ammonia levels is most commonly associated with cirrhosis or urea cycle disorders, but it can also result from renal ammoniagenesis when renal excretion of ammonium is impaired. In the literature, this has been shown to occur in the presence of (1) urinary diversion to a segment of intestine; (2) urea‐splitting ...
Victoria E. Nkunu, Kevin Y. L. Mak, Kuldeep Dodia, Fraulein D. Morales, Alicia K. J. Chan, R. Todd Alexander, Peter M. Hwang   +6 more
wiley   +1 more source

Sulfatide-Hsp70 Interaction Promotes Hsp70 Clustering and Stabilizes Binding to Unfolded Protein

Biomolecules, 2015
The 70-kDa heat shock protein (Hsp70), one of the major stress-inducible molecular chaperones, is localized not only in the cytosol, but also in extracellular milieu in mammals. Hsp70 interacts with various cell surface glycolipids including sulfatide (3'
Yoichiro Harada, Chihiro Sato, Ken Kitajima   +2 more
doaj   +1 more source