Results 41 to 50 of about 5,159 (209)

NKT cells stimulated by long fatty acyl chain sulfatides significantly reduce the incidence of type 1 diabetes in nonobese diabetic mice [corrected]. [PDF]

PLoS ONE, 2012
Sulfatide-reactive type II NKT cells have been shown to regulate autoimmunity and anti-tumor immunity. Although, two major isoforms of sulfatide, C16:0 and C24:0, are enriched in the pancreas, their relative role in autoimmune diabetes is not known. Here,
Lakshmimathy Subramanian, Hartley Blumenfeld, Robert Tohn, Dalam Ly, Carlos Aguilera, Igor Maricic, Jan-Eric Mansson, Karsten Buschard, Vipin Kumar, Terry L Delovitch   +9 more
doaj   +1 more source

Sulfatide recognition by colonization factor antigen CS6 from enterotoxigenic Escherichia coli. [PDF]

PLoS ONE, 2009
The first step in the pathogenesis of enterotoxigenic Escherichia coli (ETEC) infections is adhesion of the bacterium to the small intestinal epithelium.
Lena Jansson, Joshua Tobias, Catharina Jarefjäll, Michael Lebens, Ann-Mari Svennerholm, Susann Teneberg   +5 more
doaj   +1 more source

Polymorphonuclear Leukocyte Apoptosis Is Accelerated by Sulfatides or Sulfatides-TreatedSalmonellaTyphimurium Bacteria [PDF]

BioMed Research International, 2015
Neutrophils die by apoptosis following activation and uptake of microbes or enter apoptosis spontaneously at the end of their lifespan if they do not encounter a pathogen. Here we report that sulfatides or sulfatides-treatedSalmonellaTyphimurium bacteria accelerated human neutrophil apoptosis.
Grishina, Zoryana V., Viryasova, Galina M., Romanova, Yulia M., Sud'ina, Galina F.   +3 more
openaire   +2 more sources

Synthesis of a 2ꞌꞌ-Deoxy-β-GalCer

Molecules, 2014
Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T ...
Meena S. Thakur, Archana Khurana, Mitchell Kronenberg, Amy R. Howell   +3 more
doaj   +1 more source

Sulfatide species with various fatty acid chains in oligodendrocytes at different developmental stages determined by imaging mass spectrometry [PDF]

HSO3‐3‐galactosylceramide (Sulfatide) species comprise the major glycosphingolipid components of oligodendrocytes and myelin and play functional roles in the regulation of oligodendrocyte maturation and myelin formation.
Yamada, Hisao, Koike, Taro, Yao, Ikuko, Gotoh, Hitoshi, 26985, 26983, 26984, 26978, 26979, 26977, Honke, Koichi, Ono, Katsuhiko, 26981, 26982, 100001237, Hirahara, Yukie, 26980, 30285043, Mori, Tetsuji, Wakabayashi, Taketoshi, Tsuda, Masayuki, 2308   +21 more
core   +1 more source

Chronic caloric restriction attenuates a loss of sulfatide content in PGC-1α mouse cortex: a potential lipidomic role of PGC-1α in neurodegeneration

Journal of Lipid Research, 2012
Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), a key regulator of energy metabolism and lipid homeostasis in multiple highly oxidative tissues, has been implicated in the metabolic derangements of diabetes and obesity. However,
Michael A. Kiebish, Dee M. Young, John J. Lehman, Xianlin Han   +3 more
doaj   +1 more source

Anti-sulfatide reactivity in patients with celiac disease [PDF]

, 2017
Objective: To explore a possible significance of the presence of anti-ganglioside and anti-sulfatide antibodies in sera of adult patients with celiac disease (CD) in different clinical scenario. Methods: We selected 22 adult patients with newly diagnosed
C. Tomba, M.T. Bardella, D. Conte, D. Saccomanno, P. Backelandt, F. Magri, N. Bresolin, G.P. Comi, L. Roncoroni, L. Doneda, L. Elli   +10 more
core   +1 more source

Modest phenotypic improvements in ASA-deficient mice with only one UDP-galactose:ceramide-galactosyltransferase gene

Lipids in Health and Disease, 2006
Summary Background Arylsulfatase A (ASA)-deficient mice are a model for the lysosomal storage disorder metachromatic leukodystrophy. This lipidosis is characterised by the lysosomal accumulation of the sphingolipid sulfatide.
De Deyn PP, D'Hooge R, Mansson JE, Wittke D, Franken S, Lüllmann-Rauch R, Matzner U, Gieselmann V   +7 more
doaj   +1 more source

Prevalence and Disability of Peripheral Neuropathy in Patients With Waldenström's Macroglobulinemia

European Journal of Haematology, EarlyView.
ABSTRACT Objectives Peripheral neuropathy (PN) is considered a frequent complication of Waldenström's macroglobulinemia (WM). Establishing a causal relationship between PN and WM is complicated by confounding factors such as age‐related axonal loss and diabetes. This scoping review aims to summarize the current evidence on WM‐associated PN with a focus
Morten Müller Aagaard, Kristoffer Nagy Skaastrup, Louise Sloth Kodal, Britt Stævnsbo Pedersen, Troels Hammer, John Vissing, Tina Dysgaard   +6 more
wiley   +1 more source

A bidirectional link between sulfatide and Alzheimers disease

, 2023
Reduced sulfatide-level are found in Alzheimer’s disease (AD) patients. Here we demonstrate that amyloid-precursor-protein (APP) processing regulates sulfatide-synthesis and vice versa. Differentcell culture model and transgenic mice models devoid of APP-
Grimm, M (via Mendeley Data)
core   +1 more source