Quantification of sulfatides and lysosulfatides in tissues and body fluids by liquid chromatography-tandem mass spectrometry[S] [PDF]
Journal of Lipid Research, 2015 Sulfatides are found in brain as components of myelin, oligodendrocytes, and neurons but are also present in various visceral tissues. Metachromatic leukodystrophy (MLD) is an inherited lysosomal storage disorder caused by a deficiency of arylsulfatase A,
Mina Mirzaian +2 more
doaj +2 more sources
Sulfatides partition disabled-2 in response to platelet activation. [PDF]
PLoS ONE, 2009 BACKGROUND:Platelets contact each other at the site of vascular injury to stop bleeding. One negative regulator of platelet aggregation is Disabled-2 (Dab2), which is released to the extracellular surface upon platelet activation.
Karen E Drahos +3 more
doaj +2 more sources
The Role of Sulfatides in Liver Health and Disease
Frontiers in Bioscience-LandmarkSulfatides or 3-O-sulfogalactosylceramide are negatively charged sulfated glycosphingolipids abundant in the brain and kidneys and play crucial roles in nerve impulse conduction and urinary pH regulation. Sulfatides are present in the liver, specifically
Lin Chen +2 more
doaj +2 more sources
npj Parkinson's Disease, 2023 Metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to the neurotoxin MPP+ in the brain causes permanent Parkinson’s disease-like symptoms by destroying dopaminergic neurons in the pars compacta of the substantia nigra in humans and non ...
Ibrahim Kaya +8 more
doaj +2 more sources
Regulation of Oligodendrogenesis by Sulfatides and PDGFrα
, 2014 Sulfatides, a significant constituent of myelin, regulate oligodendrogenesis by unknown mechanism. Therefore, we hypothesized that sulfatides affect very early events during gliogenesis regulating the differentiation of multipotential neural progenitors (
Katarzyna C. Pituch (7956083)
core +6 more sources
Leukodystrophy in Tanzania: A Case Study Highlighting Diagnostic Dilemmas and Clinical Implications [PDF]
Clin Case RepABSTRACT Leukodystrophies are rare inherited neurodegenerative disorders characterized by progressive white matter dysfunction and neurological decline. In low‐resource settings, limited access to advanced neuroimaging, biochemical investigations, and genetic testing often delays diagnosis and complicates differentiation from more common infectious ...
Nkenguye W, Suleman M, Lodhia J.
europepmc +2 more sources
Sulfatides trigger cytokine gene expression and secretion in human monocytes. [PDF]
, 1994 We investigated whether sulfatides are able to trigger transmembrane signals and activation of selective cell functions in human monocytes. Sulfatides stimulated an increase in cytosolic free-calcium in monocytes, and this depended on the release of ...
BERTON, Giorgio +3 more
core +3 more sources
Acute kidney injury induced by protein-overload nephropathy down-regulates gene expression of hepatic cerebroside sulfotransferase in mice, resulting in reduction of liver and serum sulfatides [PDF]
, 2009 Sulfatides, possible antithrombotic factors belonging to sphingoglycolipids, are widely distributed in mammalian tissues and serum. We recently found that the level of serum sulfatides was significantly lower in hemodialysis patients than that in normal ...
Hu, Rui +8 more
core +2 more sources
Reprogramming lipid metabolism for cognitive restoration in Alzheimer's via PLA2G4E. [PDF]
Alzheimers Dement (N Y)Abstract INTRODUCTION Growing evidence implicates dysregulated brain lipid metabolism in Alzheimer's disease (AD) pathogenesis, influencing membrane integrity, neuroinflammation, and amyloid beta and tau pathology, thereby representing a promising therapeutic target.
Badesso S +6 more
europepmc +2 more sources
Serum sulfatide level is associated with severe systemic vasculitis with kidney involvement
Frontiers in Immunology, 2023 Sulfatides are a type of sulfated glycosphingolipid that are secreted with lipoproteins into the serum. These molecules are involved in the inflammatory pathway of vessels in addition to coagulation and platelet aggregation.
Daiki Aomura +11 more
doaj +1 more source