Results 41 to 50 of about 3,243 (149)

A Rare Case of Fatty Acid Hydroxylase‐Associated Neurodegeneration in a Pakistani Boy With a Homozygous FA2H Variant

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Fatty acid hydroxylase‐associated neurodegeneration (FAHN) is an ultra‐rare neurological disorder caused by a mutation in the FA2H gene. Defective production of this gene leads to abnormal myelin formation, which subsequently causes neurodegeneration and brain iron accumulation.
Araj Naveed Siddiqui, Yamna Naveed Siddiqui, Noor ul Huda Abbasi, Raman Kumar, Hermann Yokolo   +4 more
wiley   +1 more source

Quantitative analysis of brain galactosylceramides by high performance liquid chromatography of their perbenzoyl derivatives

Journal of Lipid Research, 1976
A high performance liquid chromatographic (HPLC) method for analysis of galactosylceramides as their benzoyl derivatives has been devised. Samples containing 10-150 nmoles of monohexosylceramides are benzoylated by heating for 60 min at 60 ° C in 0.5 ml ...
E H McCluer, J E Evans
doaj   +1 more source

High-throughput analysis of sulfatides in cerebrospinal fluid using automated extraction and UPLC-MS/MS

Journal of Lipid Research, 2017
Sulfatides (STs) are a group of glycosphingolipids that are highly expressed in brain. Due to their importance for normal brain function and their potential involvement in neurological diseases, development of accurate and sensitive methods for their ...
Maria Blomqvist, Jan Borén, Henrik Zetterberg, Kaj Blennow, Jan-Eric Månsson, Marcus Ståhlman   +5 more
doaj   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Myelination and Remyelination in Peripheral Nerve Injury: Mechanisms, Regulation, and Therapeutic Perspectives

MedComm, Volume 7, Issue 10, October 2026.
Peripheral nerve injury triggers axonal degeneration, myelin breakdown, and Schwann cell reprogramming. Remyelination requires reactivation of the SOX10–OCT6–KROX20/EGR2 transcriptional hierarchy, axonal NRG1–ErbB2/3 signaling, metabolic support, and coordinated immune regulation.
Li‐Xin Huang, Tao Sun, Yi‐Bo Zhao, Zhi‐Min Wu, Jun Sun, Ming‐Yang Li, Qing‐Yi Huo, Yun‐Mou Ou, Qing‐Tian Liang, Cong Ling, Bao‐Yu Zhang, Chuan Chen, Ying Guo, Hui Wang   +13 more
wiley   +1 more source

Profiling and semi-quantitation of urine sulfatides by UHPLC-Orbitrap-HRMS [PDF]

Background: Sulfatides are a class of sphingolipids which are abundant in the myelin sheet and oligodendrocytes, therefore they play a crucial role in the nervous system. Abnormal sulfatide excretion has been linked to several neurodegenerative disorders
Jans, Judith J.M., Schlotawa, Lars, Laugwitz, Lucia, Hoytema van Konijnenburg, Eva, Hasselt, Peter Marin van, van Hasselt, Peter, van der Ham, Maria, Ham, Maria van der, Gerrits, Johan, Prinsen, Hubertus C.M.T., Sain-van der Velden, Monique G.M. de, van Rossum, Wouter, Jans, Judith, Rossum, Wouter van, Konijnenburg, Eva M.M. Hoytema van, Prinsen, Hubertus, de Sain-van der Velden, Monique   +16 more
core   +2 more sources

Effects of inducers of differentiation on protein kinase C and CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase activities of HL-60 leukemia cells.

Journal of Lipid Research, 1989
Exposure of HL-60 leukemia cells to either 12-O-tetradecanoylphorbol-13-acetate (TPA), dimethylsulfoxide (DMSO), exogenous gangliosides GM3, GM1, or bovine brain ganglioside mixture (BBG) resulted in a marked inhibition of the growth of cells.
X J Xia, X B Gu, A C Sartorelli, R K Yu, A C Santorelli   +4 more
doaj   +1 more source

Osmotic Remodeling of Extracellular Vesicles for Precision Nanomedicine

Small, Volume 22, Issue 56, 8 October 2026.
Hypotonic lysis in bidistilled water is used to remodel B lymphocyte–derived extracellular vesicles into cargo‐depleted, structurally preserved nanovesicles. The process reduces intraluminal proteins and nucleic acids, reshapes membrane composition, and enhances tumor‐cell uptake in vitro, while allowing proof‐of‐concept reloading with exogenous agents,
Francesca Susa, Lorenzo Arnaboldi, Veronica De Giorgis, Marco Ghirimoldi, Elettra Barberis, Marco Brucale, Francesco Valle, Mario Malerba, Marta Vallino, Angelo Musicò, Roberto Frigerio, Alessandro Gori, Vera Mugoni, Claudia Voena, Roberto Pisano, Fabrizio Pirri, Silvia Arpicco, Marcello Manfredi, Tania Limongi   +18 more
wiley   +1 more source

Human urinary sulfatides in patients with sulfatidosis (metachromatic leukodystrophy)

Journal of Lipid Research, 1971
The excretion of sulfatides in human urine was studied. 24-hr urine collections were filtered. Urinary glycolipids were extracted from the filter paper and fractionated on diethylaminoethyl cellulose and silicic acid columns, and by thin-layer ...
MICHEL PHILIPPART, LOUIS SARLIEVE, COLETTE MEURANT, LASZLO MECHLER   +3 more
doaj   +1 more source

ENT1 inhibition links oligodendrocyte lipid metabolism to connectivity in tauopathy

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Metabolic dysfunction, altered adenosine signaling, and white matter abnormalities are implicated in tauopathies, but their relationship to network disconnection remains unclear. Myelinating oligodendrocytes may represent a metabolically vulnerable hub linking these processes to circuit dysfunction.
Ching‐Pang Chang, Ching‐Wen Chang, Ching‐Wen Wu, Jian Jing Siew, David Blum, Lee‐Way Jin, You‐Yin Chen, Yijuang Chern   +7 more
wiley   +1 more source