Results 81 to 90 of about 47,915 (287)

Electrochemical evaluation of glutathione S-transferase kinetic parameters [PDF]

, 2015
Glutathione S-transferases (GSTs), are a family of enzymes belonging to the phase II metabolism that catalyse the formation of thioether conjugates between the endogenous tripeptide glutathione and xenobiotic compounds.
Brett, Ana Maria Oliveira, Enache, Teodor Adrian   +1 more
core   +1 more source

Pancreatic Cancer‐Derived Extracellular Vesicles Enriched with miR‐223‐5p Promote Skeletal Muscle Wasting Associated with Cachexia

Advanced Science, EarlyView.
EVs and EV‐microRNAs (miRNAs) mediate PDAC‐skeletal muscle communication. miR‐223‐5p reduces METTL14 transcription by targeting MAFA, which subsequently decreases m6A methylation in skeletal muscles, ultimately leading to muscle wasting. This study highlights the absorption of miRNA in PDAC‐derived EVs by skeletal muscles and reveals a previously ...
Kangjing Xu, Rongxi Shen, Li Zhang, Xuejin Gao, Xinbo Wang, Changhua Zhang, Xi Chen, Xinying Wang   +7 more
wiley   +1 more source

Imaging‐Based High‐Content Screening with Clickable Probes Identifies XPB Inhibitors

Angewandte Chemie, EarlyView.
Our study introduces TL‐alkyne as an innovative tool for bio‐orthogonal labeling of endogenous XPB in live cells, facilitating the creation of a cell‐based imaging HCS assay. This platform not only enabled the identification of pelitinib as a novel XPB inhibitor but also demonstrated its potential to improve cancer treatment through synergistic effects
Shuqi Li, Hong‐Rui Zhang, Yang Yang, Ben Chi‐Bun Ko, Jin Shang, Haijun Guo, Dan Yang, Mankin Wong, Ricky Wing‐Cheung Chan, Karen Ka‐Yan Kung, Qian Zhao   +10 more
wiley   +2 more sources

Antioxidant requirements of rats exposed to 100 % oxygen. Part 2 - Effects of dietary ascorbic acid [PDF]

Dietary ascorbic acid effects as antioxidants in rats exposed to 100 percent ...
Brooksby, G. A., Menzel, D. B., Shaw, A. M.   +2 more
core   +1 more source

Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus. III. Lipid II is an in vivo peptidoglycan substrate for sortase-catalyzed surface protein anchoring [PDF]

, 2002
Surface proteins of Staphylococcus aureus are anchored to the cell wall peptidoglycan by a mechanism requiring a C-terminal sorting signal with an LPXTG motif.
Mazmanian, Sarkis K., Perry, Adrienne M., Schneewind, Olaf, Ton-That, Hung   +3 more
core  

Influence of hyperhomocysteinemia on the cellular redox state - Impact on homocysteine-induced endothelial dysfunction [PDF]

, 2003
Hyperhomocysteinemia is an independent risk factor for the development of atherosclerosis. An increasing body of evidence has implicated oxidative stress as being contributory to homocysteines deleterious effects on the vasculature.
Adachi T, Andersson A, Bagi Z, Bellamy MF, Chambers JC, Chambers JC, Chao CL, Flohé L, Forgione MA, Guttormsen AB, Huang R-FS, Kanani PM, Karlsson K, Lang D, Lentz SR, Mansoor MA, Mansoor MA, Mansoor MA, Mansoor MA, O'Donnell VB, Outinen PA, Pritchard, Rubbo H, Tawakol A, Ungvari Z, Weiss N, Wilcken DE, Woo KS, Zhang F, Zhang X   +29 more
core   +1 more source

PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Inducing ferroptosis is a promising strategy for combating tumor resistance. Upregulated PIP5K1A competes with NRF2 for KEAP1 binding, which decreases the ubiquitination degradation of NRF2 and promotes its nuclear translocation, thereby suppressing ferroptosis, and ultimately driving hepatocellular carcinoma (HCC) tumorigeneses and sorafenib ...
Mengzhou Guo, Sinuo Chen, Jialei Sun, Ruchen Xu, Zhuoran Qi, Jie Li, Lianer Zhou, Yuan Fang, Tianshu Liu, Jinglin Xia   +9 more
wiley   +1 more source

A comparison of pilot-scale supersonic direct steam injection to conventional steam infusion and tubular heating systems for the heat treatment of protein-enriched skim milk-based beverages [PDF]

, 2019
peer-reviewedDirect supersonic steam injection, direct steam infusion, and indirect tubular heating were each applied to protein-enriched skim milk-based beverages with 4, 6 and 8% (w/w) total protein, and the effect of final heat temperature on the ...
Kelleher, Clodagh M., Kelly, Alan L., McCarthy, Noel, O'Callaghan, Donal, O'Mahony, James A., Tobin, John   +5 more
core   +1 more source

Theranostic Toolbox for Neutrophil Functionalization

Advanced Science, EarlyView.
Here, neutrophil‐specific fluorine nanoparticles additionally equipped with either activating or inhibiting peptides for a background‐free 19F MRI‐based nanotheranostic approach are engineered. It is demonstrated that this approach is suitable to visualize and concomitantly direct neutrophil functionality depending on the specific requirements to ...
Pascal Bouvain, Kay‐Matthias Thomy, Anika Maria Prinz, Bodo Steckel, Shiwa Kadir, Alexandra Röhs, Jonas Schmitz, Claudia Dohle, Matthias Karg, Maria Grandoch, Ulrich Flögel, Sebastian Temme   +11 more
wiley   +1 more source

Component characterization of Smilax glabra Roxb., and its inhibitory activity against Helicobacter pylori through targeted suppression of its secreted urease

Frontiers in Cellular and Infection Microbiology
BackgroundSmilax glabra Roxb. (SGR), known as “tufuling” in China, is a medical and edible plant, which has anti-inflammatory, antibacterial and antineoplastic activity. SGR is extensively utilized in the remedy of gastroenteric disorders associated with
Ying Tang, Fan Yang, Xia Wen, Yi Zhou, Rong Tang, Xiuzhi He, Qiang Lu, Cailan Li, Cailan Li, Cailan Li   +9 more
doaj   +1 more source