Results 71 to 80 of about 11,764 (212)

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Prespacer processing and specific integration in a Type I-A CRISPR system [PDF]

, 2017
This work was supported by a grant from the Biotechnology and Biological Sciences Research Council (REF: BB/M021017/1 to MFW).The CRISPR–Cas system for prokaryotic adaptive immunity provides RNA-mediated protection from viruses and mobile genetic ...
Graham, Shirley, Rollie, Clare, Rouillon, Christophe, White, Malcolm F.   +3 more
core   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, Volume 13, Issue 18, 27 March 2026.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Crystal structure of the S. solfataricus archaeal exosome reveals conformational flexibility in the RNA-binding ring. [PDF]

PLoS ONE, 2010
The exosome complex is an essential RNA 3'-end processing and degradation machinery. In archaeal organisms, the exosome consists of a catalytic ring and an RNA-binding ring, both of which were previously reported to assume three-fold symmetry.Here we ...
Changrui Lu, Fang Ding, Ailong Ke
doaj   +1 more source

Glycerate kinase of the hyperthermophilic archaeon Thermoproteus tenax: new insights into the phylogenetic distribution and physiological role of members of the three different glycerate kinase classes [PDF]

, 2007
Background The presence of the branched Entner-Doudoroff (ED) pathway in two hyperthermophilic Crenarchaea, the anaerobe Thermoproteus tenax and the aerobe Sulfolobus solfataricus, was suggested.
Daniel Kehrer, Hatim Ahmed, Henner Brinkmann, Bettina Siebers   +3 more
core   +2 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, Volume 599, Issue 23, Page 3417-3443, December 2025.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

An AGT-based protein-tag system for the labelling and surface immobilization of enzymes on E. coli outer membrane

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The use of natural systems, such as outer membrane protein A (OmpA), phosphoporin E (PhoE), ice nucleation protein (INP), etc., has been proved very useful for the surface exposure of proteins on the outer membrane of Gram-negative bacteria.
Rosa Merlo, Sonia Del Prete, Anna Valenti, Rosanna Mattossovich, Vincenzo Carginale, Claudiu T. Supuran, Clemente Capasso, Giuseppe Perugino   +7 more
doaj   +1 more source

High-affinity RNA binding by a hyperthermophilic single-stranded DNA-binding protein [PDF]

, 2017
Single-stranded DNA-binding proteins (SSBs), including replication protein A (RPA) in eukaryotes, play a central role in DNA replication, recombination, and repair. SSBs utilise an oligonucleotide/oligosaccharide-binding (OB) fold domain to bind DNA, and
A Bochkarev, AR Mushegian, B Wu, C Dominguez, C Kim, C Touma, C Witharana, D Götz, D Suck, DA Bernstein, DJ Richard, DJ Richard, DL Theobald, E Bini, E Evguenieva-Hackenberg, E Lerner, H Chen, H Shi, ID Kerr, IJ Molineaux, J. Carlos Penedo, JE Nandakumar, Jose Peregrina, K Komori, K McCluskey, L Cubeddu, LC DeVeaux, LE Orgel, Liza Cubeddu, MA Swairjo, Malcolm F. White, MF White, Michael J. Morten, MJ Morten, NW Ashton, R Gamsjaeger, R Guo, R Sachs, R Vries de, R Zhou, RI Wadsworth, Roland Gamsjaeger, RR Meyer, Ruvini Kariawasam, S Blouin, S Dabrowski, S Paytubi, S Raghunathan, S Sun, TD Craggs, TH Dickey, U Kernchen, W Li, WT Ruyechan, Y Shamoo, Y Wu   +55 more
core   +1 more source

Groundwater Microbial Diversity Associated With Icelandic Basaltic Subsurface Environments

Environmental Microbiology Reports, Volume 17, Issue 6, December 2025.
Overview of microbial diversity and environmental drivers in Icelandic deep basaltic aquifers. Using 16S rRNA gene metabarcoding across 22 geothermal wells spanning broad temperature, pH, and bedrock‐age gradients, the study reveals distinct bacterial and archaeal community structures shaped by temperature, pH, and host‐rock reactivity.
Juliette Bas‐Lorillot, Bénédicte Ménez, Bastien Wild, Guillaume Borrel, Manon Le Bihan, Andri Stefánsson, Jóhann Gunnarsson‐Robin, Anna Bríet Bjarkadóttir, Sigríður María Aðalsteinsdóttir, Delphine Tisserand, Damien Daval, Emmanuelle Gérard   +11 more
wiley   +1 more source

Activation of SsoPK4, an Archaeal eIF2α Kinase Homolog, by Oxidized CoA

Proteomes, 2015
The eukaryotic protein kinase (ePK) paradigm provides integral components for signal transduction cascades throughout nature. However, while so-called typical ePKs permeate the Eucarya and Bacteria, atypical ePKs dominate the kinomes of the Archaea ...
William K. Ray, Mark B. Potters, January D. Haile, Peter J. Kennelly   +3 more
doaj   +1 more source