Results 121 to 130 of about 71,069 (237)

Radioiodination of Two Carborane‐Based Dual Cyclooxygenase‐2/5‐Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
Two dicarbadodecaborane(12)‐based dual cyclooxygenase‐2/5‐lipoxygenase (COX‐2/5‐LO) inhibitors were 123I‐labeled. Refinement of labeling and formulation conditions and extensive in vitro characterization are presented. Cell uptake studies in COX‐2‐ and 5‐LO‐overexpressing cell lines showed COX‐2‐independent and partly 5‐LO‐dependent uptake.
Jonas Schädlich, Martin Ullrich, Cathleen Haase‐Kohn, Robert Wodtke, Sebastian Braun, Maximilian Molitor, Bettina Hofmann, Dieter Steinhilber, Klaus Kopka, Evamarie Hey‐Hawkins, Jens Pietzsch, Markus Laube   +11 more
wiley   +1 more source

PharmVar GeneFocus: NAT2—Genetic Variation and Updated Nomenclature

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 859-871, April 2026.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N‐acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines.
Georgia Papanikolaou, Estella S. Poloni, José A.G. Agúndez, Raquel L.F. Teixeira, Erin C. Boone, Adalberto Rezende Santos, Michelle Whirl‐Carrillo, Katrin Sangkuhl, Teri E. Klein, Mariam R. Habil, Giannoulis Fakis, Rodney F. Minchin, David W. Hein, Sotiria Boukouvala, Andrea Gaedigk   +14 more
wiley   +1 more source

Polyoxometalate-ionic liquid functionalized magnetic nanocomposites for solid phase extraction and HPLC determination of sulfonamides in food samples. [PDF]

RSC Adv
Nazar Z, Binzowaimil AM, Iram S, Tayyab Ishaq M, Sajid M, Asif HM, Al-Hmoud M, Khan MS.   +7 more
europepmc   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 891-904, April 2026.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

Click Chemistry-Enabled Parallel Synthesis of N-Acyl Sulfonamides and Their Evaluation as Carbonic Anhydrase Inhibitors. [PDF]

Molecules
Gavrylenko OV, Vashchenko BV, Naumchyk V, Sosunovych BS, Chuk O, Hrabovskyi O, Kuchuk O, Pogribna A, Nikitin SO, Konovets AI, Brovarets VS, Zozulya SA, Radchenko DS, Grygorenko OO, Moroz YS.   +14 more
europepmc   +1 more source

Microbial Etiology and Antimicrobial Resistance in Pneumonia Among Hospitalized Patients in Kazakhstan: A Systematic Review and Single‐Arm Meta‐Analysis of Prevalence Data

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Pneumonia is an inflammatory condition of the lower respiratory tract, commonly caused by infection and associated with substantial morbidity and healthcare utilization. The burden of pneumonia on healthcare is exacerbated by limited data on pathogenic causes and associated antimicrobial resistance (AMR). Here, we conducted
Radmir Sarsenov, Maxim Solomadin, Alyona Lavrinenko, Vyacheslav Beloussov, Vitaliy Strochkov, Shynggys Orkara, Nurlan Sandybayev, Sergey Yegorov   +7 more
wiley   +1 more source

By Chance, Not Design: A New Furosemide Derivative From Zinc(II) Complex Studies. [PDF]

ACS Omega
Podjed Rihtaršič N, Cerc Korošec R, Modec B.   +2 more
europepmc   +1 more source

Emerging Antimicrobial Resistance in Klebsiella pneumoniae: A Molecular and Antibiogram Insight From the Beef Value Chain in Bangladesh

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
A total of 132 Multidrug‐resistant Klebsiella pneumoniae was detected across the beef value chain in Bangladesh, including slaughterhouses, wet markets, and ready‐to‐eat beef outlets. Upon cultural traits, PCR, 16S rRNA sequencing, antibiogram analysis, and ARG detection revealed carbapenem resistance genes (blaIMP and blaBIC), highlighting foodborne ...
Md Sodor Uddin, Fahmida Jahan Fahim, Sohel Rana, Abdullah Al Kafi, Jobaida Khanam, Md Nazim Uddin, Md Masudur Rahman, Monira Noor, Md Mukter Hossain, Md Mahfujur Rahman, Md Bashir Uddin, Ferdaus Mohd Altaf Hossain   +11 more
wiley   +1 more source

CA IX Inhibition by a Sulfonamide Compound: A Therapeutic Approach Against Breast Cancer. [PDF]

Chem Biodivers
Akmese S, Temiz E, Gürel E, Koyuncu I, Durgun M, Guldur ME, Egi K, Ozerol B.   +7 more
europepmc   +1 more source

Imported Retail Beef and Chicken Meat Products Serve as Reservoirs for Emerging Antibiotic‐Resistant Pathotypes of Escherichia coli in Pristine Areas Free From Agricultural Activity

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Retail meat–derived E. coli frequently harbored multidrug‑resistance phenotypes, diverse virulence determinants, and plasmid‑encoded resistance genes with high conjugative potential. Results indicate meat and poultry as underrecognized reservoirs facilitating dissemination of antimicrobial resistance and pathogenic lineages, with imported products ...
Saehah Yi, Kathleen A. Alexander, Auja Bywater, Galaletsang Dintwe, Ashton N. Sies, Thomas H. Haidl, Andrew D. S. Cameron, Monica A. Ponder   +7 more
wiley   +1 more source