Results 111 to 120 of about 110,887 (393)
British Journal of Clinical Pharmacology, EarlyView.Aims Sulfamethoxazole–trimethoprim (SMX‐TMP) is a widely used antibiotic for treating bacterial infections, but its safety in adult outpatients remains understudied. This systematic review and meta‐analysis evaluated the safety profile of SMX‐TMP and identified critical research gaps.
Rebecca Preyra +4 more
wiley +1 more source
Comparative Study of the Antibacterial Activity of N, N-Diethylamido Substituted p-Toluenesulfonamides to their α-Toluenesulfonamide Counterparts [PDF]
, 2015 Reaction of p-toluenesulfonyl chloride with amino acids gave sulfonamides p-T1a-k which upon amidation afforded p-T2a-k. Similarly, treatment involving α-toluenesulfonyl chloride and amino acids afforded the sulfonamides α-T1a-k.
Ajani, O. O. +5 more
core +4 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 A series of nanomolar phosphonate matrix metalloproteinase (MPP) inhibitors was tested for inhibitory activity against a panel of selected human carbonic anhydrase (CA, EC 4.2.1.1) isozymes, covering the cancer-associated CA IX and XII.
Grazia Luisi +8 more
doaj +1 more source
Investigation on biological activities of anthranilic acid sulfonamide analogs [PDF]
, 2011 In the previous studies, the cytotoxicities of anthranilate sulfonamides were investigated. Herein, the bioactivities of 4-substituted (X = NO2, OCH3, CH3, Cl) benzenesulfonamides of anthranilic acid (5-8) are reported.
Doungsoongnuen, Sutanun +6 more
core
Selective Late‐Stage Sulfonyl Chloride Formation from Sulfonamides Enabled by Pyry‐BF4
Angewandte Chemie, 2019 Reported here is a simple and practical functionalization of primary sulfonamides, by means of a pyrylium salt (Pyry‐BF4), with nucleophiles. This simple reagent activates the poorly nucleophilic NH2 group in a sulfonamide, enabling the formation of one ...
Alejandro Gómez-Palomino +1 more
semanticscholar +1 more source
Fighting Antibiotic Resistance: Insights Into Human Barriers and New Opportunities
BioEssays, EarlyView.Antibiotic resistance is a public health issue leading to the emergence of multi‐resistant bacteria. Human‐dependent factors are now driving the increase of resistance, notably through antibiotic misuse in human and animal health and environmental pollution.
Aubin Pitiot +3 more
wiley +1 more source
Revista Colombiana de Química, 2016 Extended Hildebrand Solubility Approach (EHSA) was applied to evaluate the solubility of sulfadiazine, sulfamerazine, and sulfamethazine in some ethanol + water mixtures at 298.15 K.
Daniel R. Delgado +2 more
doaj +1 more source
X‐ray controlled release strategy in cancer therapy
BMEMat, EarlyView.A comprehensive review on the design principles and current strategies of X‐ray stimulated release systems in cancer therapy, focusing on the X‐ray responsive functional groups and materials as well as discussing the advantages and current challenges of X‐ray controlled release systems in cancer therapy.
Yiling Ruan +5 more
wiley +1 more source
Journal of Freshwater Ecology, 2019 For a better understanding of the metabolic adaptations to sulfonamide (SA) stress in submerged macrophytes, the alterations of nutrient element uptake and secondary metabolism were studied in the leaves of Vallisneria natans (Lour.) Hara exposed to 0 ...
Houtao Xu +4 more
doaj +1 more source
Supramolecular synthon hierarchy in sulfonamide cocrystals with syn-amides and N-oxides
IUCrJ, 2019 Sulfonamide drugs are well known antibacterial and antimicrobial molecules for pharmaceutical development. Building a library of suitable supramolecular synthons for the sulfonamide functional group and understanding their crystal structures with partner
Geetha Bolla, Ashwini Nangia
doaj +1 more source