Results 141 to 150 of about 45,088 (258)

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

Reusing Poly(ether sulfone) Waste via Friedel-Crafts Alkylation for Bacterial Elimination. [PDF]

ACS Omega
Wang Y, Zhao Z, Guo J, Gao H, Sun X, Jiang S, Shao L.   +6 more
europepmc   +1 more source

Schwefel‐gesteuerter Aufbau von Vinylcyclopropanen ausgehend von 1,3‐Dienen

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Schwefel übernimmt die Kontrolle: Ein Thioether wirkt als molekularer Dirigent, der die Carbenaddition an 1,3‐Diene mit außergewöhnlicher Regio‐ und Diastereokontrolle lenkt. Dabei werden schwefelhaltige Vinylcyclopropane (S‐VCPs) erhalten, die mittels herkömmlicher Methoden nur schwer zugänglich sind.
Anna Keimer, Jonas Rettig, Tim‐Niclas Streit, Bob Barthel, Mélissa Calmels, Moritz Malischewski, Franz‐Lucas Haut   +6 more
wiley   +1 more source

Geminale Difunktionalisierung von Ketonen durch C–S Bindungs‐insertion photogenerierter Donor–Donor Diazoverbindungen

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Die geminale Difunktionalisierung leicht verfügbarer Bausteine ermöglicht einen schnellen Zugang zu molekularer Komplexität. Diese Arbeit stellt eine Strategie vor, um zwei unterschiedliche funktionelle Gruppen an einem Carbonylkohlenstoff zu installieren, indem dieser in eine Donor–Donor‐Diazo‐Verbindung überführt wird. Die Methode ist sowohl im Batch‐
Vincent George, Aryaman Pattanaik, Daniel Maddox, Lukas M. Sigmund, Giovanna Mejia, Sara Pahlén, Simon O. Angerer, Maria Schmoll, Lisa Marie Schneider, Nidhal Selmi, Mikhail Kabeshov, Giulia Bergonzini, Julia Rehbein, Burkhard König   +13 more
wiley   +1 more source

Peptidomimetic α,β-Unsaturated Ethyl Esters Are Irreversible Inactivators of Human Cathepsin L and Are Potent Inhibitors of SARS-CoV-2 in Cellular Models of COVID-19. [PDF]

J Med Chem
Kumar V, Drelich A, Chenna BC, Rademacher A, Kemp AM, Bishop AC, Saenkham-Huntsinger P, Scott E, Wand AJ, Laganowsky A, Tseng CT, Meek TD.   +11 more
europepmc   +1 more source

Repurposing Oxfendazole for Onchocerciasis: Population Pharmacokinetics of a Tablet Formulation in Healthy African Adults. [PDF]

CPT Pharmacometrics Syst Pharmacol
Assmus F, Adehin A, Hoglund RM, Nyaulingo G, Mbarak H, Jongo S, Ackermann E, Reus E, Keiser J, Rocha FBDS, Specht S, Scandale I, Tarning J.   +12 more
europepmc   +1 more source

Sulfur‐Directed Construction of Vinyl Cyclopropanes from 1,3‐Dienes

Angewandte Chemie International Edition, Volume 65, Issue 25, 15 June 2026.
Sulfur takes control. A pending thioether acts as a molecular compass, directing carbene addition to the 1,3‐diene scaffold with exceptional regio‑ and diastereocontrol to forge sulfur‐substituted vinyl cyclopropanes (S‐VCPs) — molecular architectures inaccessible via conventional cyclopropanation strategies.
Anna Keimer, Jonas Rettig, Tim‐Niclas Streit, Bob Barthel, Mélissa Calmels, Moritz Malischewski, Franz‐Lucas Haut   +6 more
wiley   +1 more source

Geminal Difunctionalization of Ketones via C─S Bond Insertion of Photogenerated Donor–Donor Diazo Compounds

Angewandte Chemie International Edition, Volume 65, Issue 25, 15 June 2026.
Geminal difunctionalization of readily available building blocks provides rapid access to molecular complexity. This work introduces a strategy for installing two distinct functional groups on a carbonyl carbon by transforming it into a donor–donor diazo compound, enabling both batch and flow applications with broad solvent compatibility.
Vincent George, Aryaman Pattanaik, Daniel Maddox, Lukas M. Sigmund, Giovanna Mejia, Sara Pahlén, Simon O. Angerer, Maria Schmoll, Lisa Marie Schneider, Nidhal Selmi, Mikhail Kabeshov, Giulia Bergonzini, Julia Rehbein, Burkhard König   +13 more
wiley   +1 more source

Glutathione-Responsive Fragmentation of Heteronorbornadiene-Based Thiovinyl Sulfones in Glioma Cells. [PDF]

Bioconjug Chem
Carranza M, Carmona AT, Gil de Montes E, Méndez Y, Černauskienė I, Bernardes GJL, Moreno-Vargas AJ.   +6 more
europepmc   +1 more source

MnCl2‐Catalyzed Photochemical Functionalization of Unactivated C(sp3)H Bonds

ChemSusChem, Volume 19, Issue 11, 15 June 2026.
A photochemical method enables the activation of alkanes, utilizing cheap and abundant MnCl2 as the photocatalyst. Alkenylation and alkylation reactions are performed, affording the desired products in good yields. Activation of inert C(sp3)H bonds is of great importance in organic synthesis, since it can functionalize unreactive molecules, such as ...
Naya A. Stini, Olga G. Mountanea, Vera P. Demertzidou, Christoforos G. Kokotos   +3 more
wiley   +1 more source