Results 271 to 280 of about 2,674,072 (303)

Four novel splice variants of sulfonylurea receptor 1

American Journal of Physiology-Cell Physiology, 2002
ATP-sensitive K+ (KATP) channels are composed of pore-forming Kir6.x subunits and regulatory sulfonylurea receptor (SUR) subunits. SURs are ATP-binding cassette proteins with two nucleotide-binding folds (NBFs) and binding sites for sulfonylureas, like glibenclamide, and for channel openers.
Annette, Hambrock, Regina, Preisig-Müller, Ulrich, Russ, Anke, Piehl, Peter J, Hanley, John, Ray, Jürgen, Daut, Ulrich, Quast, Christian, Derst   +8 more
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Regional distribution of sulfonylurea receptors in the brain of rodent and primate

Neuroscience, 1993
Glibenclamide, one of the most potent antidiabetic sulfonylureas, inhibits the activity of ATP-sensitive K+ channels in the pancreas as well as in the brain through its binding to specific receptors. Quantitative autoradiography was used to localize such receptors in the brain of rat, mouse, guinea-pig and marmoset, using [3H]glibenclamide as ...
S, Zini, E, Tremblay, H, Pollard, J, Moreau, Y, Ben-Ari   +4 more
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Sulfonylurea receptors, ion channels, and fruit flies

Diabetes, 1988
Recent studies have identified a high-affinity receptor on the plasma membrane of the β-cell that is specific for all of the sulfonylureas. The most potent secondgeneration drugs, glyburide and glipizide, bind to the receptor and trigger insulin release at nanomolar concentrations.
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Molecular docking of sulfonylureas to the SUR1 receptor

2021
Molecular docking is a powerful tool in drug discovery. It intuitively presents invisible bonds and atoms in a visible way so that it makes drug discovery more efficient and affordable. In recent years, it has become one of the most commonly used methods in drug discovery. Drug design has shifted from a tool purely focusing on molecular interactions to
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Characterization of sulfonylurea receptors in isolated human pancreatic islets

Journal of Cellular Biochemistry, 1998
Current information on pancreatic islet sulfonylurea receptors has been obtained with laboratory animal pancreatic beta cells or stable beta-cell lines. In the present study, we evaluated the properties of sulfonylurea receptors of human islets of Langherans, prepared by collagenase digestion and density-gradient purification.
GIANNACCINI, GINO, LUPI R., TRINCAVELLI, MARIA LETIZIA, NAVALESI R., BETTI, LAURA, MARCHETTI, PIERO, LUCACCHINI, ANTONIO, DEL GUERRA S., MARTINI, CLAUDIA   +8 more
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The KATP Channel and the Sulfonylurea Receptor

2001
ATP-sensitive K+ channels (KAgp channels) were first described in cardiac myocytes (1) and were subsequently found in many other tissues including pancreatic 13-cells (25), skeletal muscle (6), smooth muscle (7), brain (8), pituitary (9), and kidney (10) and in mitochondria (11).
Susumu Seino, Takashi Miki, Hideki Yano
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Role of the sulfonylurea receptor in regulating human adipocyte metabolism

The FASEB Journal, 1999
ABSTRACT A regulatory role for intracellular Ca 2+ ([Ca 2+ ] i ) in adipocyte lipogenesis, lipolysis and triglyceride accumulation has been demonstrated.
H, Shi, N, Moustaid-Moussa, W O, Wilkison, M B, Zemel   +3 more
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Sulfonylurea receptor–associated channels

Neurology, 2017
The sulfonylurea receptors (SURs) 1 (SUR1) and 2 (SUR2) are members of the adenosine triphosphate (ATP) binding cassette transporters superfamily. Unlike other members of this superfamily, these receptors are not involved in transport but associate with pore-forming subunits to form cation channels.
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Differential Immunolocalization of Sulfonylurea Receptors in Mouse and Rat Ureters

Anatomia, Histologia, Embryologia, 2012
SummaryThe receptors for sulphonylurea (SURs) are known to be expressed in the mouse kidney, but their expression in the ureter is undefined. Owing to the physiological and pharmacological significance ofSURs, the localization ofSURin ureters of adult mice and rats was investigated through immunohistochemistry. Animals were perfused transcardially with
I Z, Qureshi, S J, White
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Control of insulin secretion by sulfonylureas, meglitinide and diazoxide in relation to their binding to the sulfonylurea receptor in pancreatic islets

Biochemical Pharmacology, 1989
Sulfonylureas inhibit an ATP-dependent K+ channel in the B-cell plasma membrane and thereby initiate insulin release. Diazoxide opens this channel and inhibits insulin release. In mouse pancreatic islets, we have explored whether other targets for these drugs must be postulated to explain their hypo- or hyperglycaemic properties. At non-saturating drug
U, Panten, J, Burgfeld, F, Goerke, M, Rennicke, M, Schwanstecher, A, Wallasch, B J, Zünkler, S, Lenzen   +7 more
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