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Molecular docking of sulfonylureas to the SUR1 receptor
2021Molecular docking is a powerful tool in drug discovery. It intuitively presents invisible bonds and atoms in a visible way so that it makes drug discovery more efficient and affordable. In recent years, it has become one of the most commonly used methods in drug discovery. Drug design has shifted from a tool purely focusing on molecular interactions to
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Regional distribution of sulfonylurea receptors in the brain of rodent and primate
Neuroscience, 1993Glibenclamide, one of the most potent antidiabetic sulfonylureas, inhibits the activity of ATP-sensitive K+ channels in the pancreas as well as in the brain through its binding to specific receptors. Quantitative autoradiography was used to localize such receptors in the brain of rat, mouse, guinea-pig and marmoset, using [3H]glibenclamide as ...
S, Zini +4 more
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Sulfonylurea receptor–associated channels
Neurology, 2017The sulfonylurea receptors (SURs) 1 (SUR1) and 2 (SUR2) are members of the adenosine triphosphate (ATP) binding cassette transporters superfamily. Unlike other members of this superfamily, these receptors are not involved in transport but associate with pore-forming subunits to form cation channels.
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Sulfonylurea receptors and mechanism of sulfonylurea action
Experimental and Clinical Endocrinology and Diabetes, 1996C Schwanstecher +2 more
exaly
Nihon rinsho. Japanese journal of clinical medicine, 2003
Hisamitsu, Ishihara, Yoshitomo, Oka
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Hisamitsu, Ishihara, Yoshitomo, Oka
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Nihon rinsho. Japanese journal of clinical medicine, 1997
Y, Yamada, Y, Seino
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Y, Yamada, Y, Seino
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