Results 211 to 220 of about 5,907 (256)
Progress in the Treatment of Ulcerative Colitis by Targeting NLRP3 Inflammasome. [PDF]
Drug Des Devel TherChen J +6 more
europepmc +1 more source
Metabolomic profiling and vitamin D pathway investigation in diabetic foot ulcer patients. [PDF]
MetabolomicsReveendran R +5 more
europepmc +1 more source
Pharmacometabolomics of sulfonylureas in patients with type 2 diabetes: a cross-sectional study. [PDF]
J Pharm Pharm SciNaja K +3 more
europepmc +1 more source
Characterization of sulfonylurea receptors in isolated human pancreatic islets
Journal of Cellular Biochemistry, 1998 Current information on pancreatic islet sulfonylurea receptors has been obtained with laboratory animal pancreatic beta cells or stable beta-cell lines. In the present study, we evaluated the properties of sulfonylurea receptors of human islets of Langherans, prepared by collagenase digestion and density-gradient purification.
Gino Giannaccini +2 more
exaly +5 more sources
Expression of sulfonylurea receptors in rat taste buds
Acta Histochemica, 2011 To test the possibility that a fast-onset promoting agent repaglinide may initiate prandial insulin secretion through the mechanism of cephalic-phase insulin release, we explored the expression and distribution character of sulfonylurea receptors in rat taste buds. Twenty male Wistar rats aged 10 weeks old were killed after general anesthesia.
Xiao-Min Liu
exaly +4 more sources
Sulfonylurea receptors and mechanism of sulfonylurea action
Experimental and Clinical Endocrinology & Diabetes, 2009 Binding of hypoglycemic sulfonylureas and their analogues to the sulfonylurea receptor in the beta-cell plasma membrane mediates closure of the ATP-sensitive K+-channel (KATP-channel) and thereby stimulation of insulin release. The sulfonylurea receptor is a member of the traffic ATPase family with two intracellular nucleotide binding folds.
U, Panten +2 more
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Pancreatic and Extrapancreatic Sulfonylurea Receptors
Hormone and Metabolic Research, 1992The hypoglycemic effect of sulfonylureas and their analogues results from their binding to a high affinity site in the B-cell plasma membrane. This site seems to be a structural component of the ATP-sensitive K(+)-channel and represents the pancreatic sulfonylurea receptor.
U Panten, Christina Schwanstecher
exaly +3 more sources
A New Mesangial Triumvirate: Sulfonylureas, Their Receptors and Endosulfines
Nephron Experimental Nephrology, 2002 Although sulfonylureas have long been therapeutically utilized for their hypoglycemic properties in type 2 diabetic patients, there is a paucity of clinical or experimental data that suggests that this pharmacotherapeutic class confers a benefit on the course of diabetic renal disease.
Jerry, Yee, Balàzs, Szamosfalvi
openaire +3 more sources
Sulfonylurea Receptors, Ion Channels, and Fruit Flies
Diabetes, 1988Recent studies have identified a high-affinity receptor on the plasma membrane of the β-cell that is specific for all of the sulfonylureas. The most potent secondgeneration drugs, glyburide and glipizide, bind to the receptor and trigger insulin release at nanomolar concentrations.
A E Boyd
exaly +3 more sources
Differential Immunolocalization of Sulfonylurea Receptors in Mouse and Rat Ureters
Anatomia, Histologia, Embryologia, 2012 SummaryThe receptors for sulphonylurea (SURs) are known to be expressed in the mouse kidney, but their expression in the ureter is undefined. Owing to the physiological and pharmacological significance ofSURs, the localization ofSURin ureters of adult mice and rats was investigated through immunohistochemistry. Animals were perfused transcardially with
I Z, Qureshi, S J, White
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