Results 201 to 210 of about 545,902 (261)

Potential drug-drug interactions in hospitalized patients with acute coronary syndrome at a tertiary care hospital in upper Egypt. [PDF]

Front Pharmacol
Ghabesha AA, Hassan SB, Hasan-Ali H, Abdel-Latif MMM.   +3 more
europepmc   +1 more source

Barriers, Limitations, and Experiences with Clinical Trials-Treatment in Rare Diseases with Prader-Willi Syndrome as an Example. [PDF]

Genes (Basel)
Butler MG, Silvey S, van Bosse HJP.
europepmc   +1 more source

Kinetic Compatibility as a Predictor of PTP1B Inhibitor Combination Outcomes: An Integrated Experimental and Computational Study

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Combining PTP1B inhibitors of distinct kinetic mechanisms determines their pharmacological outcome. Integrating enzyme kinetics, docking, molecular dynamics, and membrane‐permeability simulations, we show that mechanistically compatible pairs (competitive + competitive; uncompetitive + mixed) yield additivity, whereas competitive + uncompetitive ...
Jonathan Trapala, Laura I. Álvarez‐Añorve, Nathaly Vasquez‐Martínez, Erika Chavira‐Suárez, Luz Vásquez‐Bochm, Deyamira Matuz‐Mares, Francisco Cortés‐Benítez, Martin González‐Andrade   +7 more
wiley   +1 more source

Personalized Diabetes Therapy Part 2-Individual Diabetes Treatment (Standard of Care Plus, SOC+). [PDF]

J Pers Med
Jantz J, Pfützner A.
europepmc   +1 more source

Sulfonylurea Bioisosteres of Sulfonic Acid in JFD 00458‐Based ST6GAL1 Inhibitors Enhance Membrane Permeability

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
ST6GAL1 sialylates glycoconjugates in the Golgi, modulating immune recognition and enabling tumor immune evasion. To effectively reach ST6GAL1, inhibitors should demonstrate good membrane permeability. Based on nonpermeable hit JFD 00458, we developed sulfonylurea analogs achieving increased membrane permeability and potency.
Natan Koraj, Sushmaa Dangudubiyyam, Adelyn M. Betances‐Mora, Ema Faganeli, Anne Harduin‐Lepers, Jesús Angulo, Tan Khanh Nguyen, María Bort‐Griñó, Ramon Hurtado‐Guerrero, Marko Anderluh   +9 more
wiley   +1 more source

Carbutamide, an Obsolete Anti-Diabetic Drug, Has Potential as a Potent Anticolitic Agent via Azo-Conjugation with Mesalazine. [PDF]

Pharmaceutics
Ju S, Kim S, Kim T, Yoo JW, Yoon IS, Kim E, Jung Y.   +6 more
europepmc   +1 more source

ArcDFI: Attention regularization guided by CYP450 interactions for predicting drug-food interactions. [PDF]

PLoS Comput Biol
Gim M, Kang J, Park D, Jeon M.
europepmc   +1 more source

Risk of Depression With Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists Compared to Other Antidiabetic Medications in Adults With Type 2 Diabetes: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Ferrer Zavala GM, Caro Rodriguez CF, Carrion Carrion P, Martinez Artiga L, Morales Del Cid ZY, Chia JE, Valladares C.   +6 more
europepmc   +1 more source

Association between antidiabetic drug targets and psychiatric disorders. [PDF]

Schizophrenia (Heidelb)
Yuan R, Zhao G, Lu Z, Zhu Y, Kang Z, Zhang Y, Sun Y, Yang Y, Liao Y, Feng X, Sun J, Guo J, Yue W.   +12 more
europepmc   +1 more source

Two for the heart: Dutch Pharmacogenetic Working Group prescribing guidance on statins and sulfonylureas to reduce cardiometabolic risk. [PDF]

Eur J Hum Genet
David SP.
europepmc   +1 more source