Results 51 to 60 of about 5,907 (256)

Safety and Efficacy of Glucagon‐Like Peptide‐1 Receptor Agonists Use in Elderly People With Obesity—A Meta‐Analysis

Obesity, EarlyView.
ABSTRACT Objective This meta‐analysis evaluates the safety and efficacy of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) for the treatment of older adults with obesity compared to younger individuals. Methods A systematic review was conducted following PRISMA guidelines (PROSPERO CRD420251074381).
Inês Rego de Figueiredo, Filipa Sofia Simas, Angela Ghiletchi, João Oliveira Torres, José Silva‐Nunes   +4 more
wiley   +1 more source

UNI‐494 treatment improves measures of renal dysfunction and cardiac pathology in male rats receiving L‐NAME and angiotensin II

Physiological Reports
Mitochondrial dysfunction is essential in the pathophysiology of both cardiovascular disease (CVD) and chronic kidney disease (CKD). Nicorandil, a nicotinamide nitrate derivative, has been used for years as a cardioprotective agent.
Fiona Jing Min Ho, Clarice Jing Rou Siow, Hayat Aljaibeji, Miao Ding, Richard N. Mitchell, Satya Medicherla, Guru Reddy, Shalabh Gupta, Gordon H. Williams, Jose R. Romero   +9 more
doaj   +1 more source

Interaction of fluorescein derivatives with glibenclamide binding sites in rat brain.

, 1995
In rat brain, [3H]glibenclamide binds with high affinity to sulfonylurea receptors associated with ATP-sensitive potassium (KATP) channels. KATP channels may play a modulatory role in neurotransmitter release and are involved in acute pathological events
Maloteaux, Jean-Marie, Octave, Jean-Noël, Jean-Marie Maloteaux, Olivier Feron, Jean-Noël Octave, Holemans, S., Feron, Olivier, Sophie Holemans   +7 more
core   +1 more source

A Trp574–Leu substitution confers resistance to three classes of acetolactate synthase inhibitors in Australian brome grass (Bromus diandrus)

Pest Management Science, EarlyView.
Target‐site based imidazolinone resistance in brome grass was found to be conferred by a mutation at position 574 in the ALS gene and to severely impact the efficacy of the herbicide Intervix®, a co‐formulation of imazamox and imazapyr. Abstract BACKGROUND Brome grass (Bromus diandrus) is a prevalent weed in southern Australian cropping regions which ...
Roberto Busi, Danica Goggin, Nick Eyres, Fabian Runge, Aimone Porri, Ken Flower   +5 more
wiley   +1 more source

Determination of the molecular mass of the native β‐cell sulfonylurea receptor [PDF]

FEBS Letters, 1994
In the present study we have determined the molecular mass of the β‐cell sulfonylurea receptor in its native form by two different experimental approaches; gel filtration chromatography and radiation inactivation analysis. We first confirmed that the denatured photolabelled MIN6 β‐cell receptor had a molecular size of 141 ± 2 kDa (mean ± S.E., n = 8 ...
Skeer, J, Dégano, P, Coles, B, Potier, M, Ashcroft, F, Ashcroft, S   +5 more
openaire   +3 more sources

Estudo do efeito e do mecanismo de ação das sulfonamidas e acilhidrazonas sintéticas na homeostasia da glicose [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2014.Durante as últimas décadas, observou-se um aumento surpreendente na prevalência do diabetes melito (DM)
Frederico, Marisa Jádna Silva
core  

The sulfonylurea glimepiride regulates intracellular routing of the insulin-receptor complexes through their interaction with specific protein kinase C isoforms

, 2001
Sulfonylureas may stimulate glucose metabolism by protein kinase C (PKC) activation. Because interaction of insulin receptors with PKC plays an important role in controlling the intracellular sorting of the insulin-receptor complex, we investigated the ...
SESTI G, D'ALFONSO, ROSSELLA, Barbara Giovannone, Lauro, D, Liu, YY, FEDERICI, MASSIMO, BORBONI, PATRIZIA, LIU YY, Federici, M, GIOVANNONE B, D'Alfonso, R, Borboni, P, BORBONI P, Yong Yu Liu, Davide Lauro, Hribal, ML, Marta Letizia Hribal, Renato Lauro, HRIBAL ML, Sesti, G., Patrizia Borboni, Massimo Federici, Lauro, R, LAURO R, LAURO, DAVIDE, Rossella D'Alfonso, LAURO D, Giovannone, B, Sesti, G, Giorgio Sesti, D'ALFONSO R, FEDERICI M, LAURO, RENATO   +32 more
core   +1 more source

Pro‐197 mutations confer resistance to thiencarbazone but not to foramsulfuron in ALS‐resistant Poa annua populations

Pest Management Science, EarlyView.
Foramsulfuron remains effective on Pro‐197 Poa annua, but co‐formulation with thiencarbazone reduces efficacy due to limited activity and antagonism. Therefore, foramsulfuron + thiencarbazone should be used in fields without ALS‐resistant weeds to ensure effective in‐crop control.
Vijaya Bhaskar Alwarnaidu Vijayarajan, Iniya Vijayakumar, Rafa Ruiz‐Partida, Fabian Runge, Joel Torra, Jorge Lozano‐Juste, Patrick Dermot Forristal   +6 more
wiley   +1 more source

Ontogeny of sulfonylurea-binding regulatory subunits of KATP channels in the pregnant rat myometrium

, 2011
ATP-sensitive potassium channels (KATPchannels) are composed of sulfonylurea receptors (SURs) and potassium inward rectifiers (Kir6.x) that assemble to form a large octameric channel.
N Lovasz, E Ducza, R Gaspar, G Falkay
core   +1 more source

Studi Docking senyawa-senyawa aktif Buah Pare (Momordica Charantia L.) golongan Charantoside pada Reseptor Sulfonylurea sel beta pankreas [PDF]

, 2021
INDONESIA: Diabetes mellitus (DM) yang tergolong dalam penyakit kronis muncul ketika pankreas dalam kondisi tidak mampu memproduksi insulin dan menggunakannya secara efektif.
Ramadhan, Rohadatul 'Aisy Khansa
core