Results 71 to 80 of about 5,907 (256)

L2 target class distribution of both the allosteric (A) and non-allosteric data (B) sets.

, 2014
The distribution of the target classes differed between the two sets; which confirmed that targets that are easy to hit via non-allosteric inhibitors are not necessarily easy to hit via an allosteric modulator and vice versa.
Gerard J. P. van Westen (195154), John P. Overington (188498), Anna Gaulton (547084)   +2 more
core   +1 more source

Putative subunits of the rat mesangial KATP: A type 2B sulfonylurea receptor and an inwardly rectifying K+ channel

, 2002
Putative subunits of the rat mesangial KATP: A type 2B sulfonylurea receptor and an inwardly rectifying K+ channel.BackgroundSulfonylurea agents exert their physiological effects in many cell types via binding to specific sulfonylurea receptors (SUR ...
Alviani, Rebecca, Riser, Bruce L, Zasuwa, Gerald, Cortes, Pedro, Zasuwa, Gary, Riser, Bruce L., Szamosfalvi, Balázs, Asano, Kenichiro, Yee, Jerry   +8 more
core   +1 more source

Association Between SGLT2 Inhibitors and DPP‐4 Inhibitors Use and Risk of Acute Pancreatitis: Findings From Nationwide Case‐Based Analyses

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The Korean national health insurance claims database was utilised to investigate the association between sodium–glucose cotransporter 2 inhibitors (SGLT2i) or dipeptidyl peptidase‐4 inhibitors (DPP‐4i) and the risk of acute pancreatitis (AP). Materials and Methods Patients with type 2 diabetes mellitus prescribed DPP‐4i or SGLT2i at least
Ye‐Jee Kim, Yun Kyung Cho, Mi‐Sook Kim, Joongyub Lee, Seonghae Kim, Bo Ram Yang   +5 more
wiley   +1 more source

Efeito terapêutico do galato de etila na nocicepção neuropática e induzida por algógenos em camundongos [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2014.O galato de etila (GE) é um composto fenólico encontrado em um grande número de espécies de ...
Coelho, Igor dos Santos
core  

Structural basis for the interference between nicorandil and sulfonylurea action.

, 2001
Nicorandil is a new antianginal agent that potentially may be used to treat the cardiovascular side effects of diabetes. It is both a nitric oxide donor and an opener of ATP-sensitive K(+) (K(ATP)) channels in muscle and thereby causes vasodilation of ...
Ashcroft, FM, Reimann, F, Ashcroft, Frances, Gribble, FM   +3 more
core   +1 more source

Association Between Glucagon‐Like Peptide‐1 Receptor Agonists and Suicidality: A Systematic Review

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims We aimed to examine the association between GLP‐1 RA use and suicidal ideation or behaviours through a systematic review of observational studies. Materials and Methods A comprehensive search of MEDLINE, PubMed, EMBASE, CINAHL and PsycINFO was conducted from database inception through December 11, 2025. Observational studies investigating
Timothy H. Chan, Leon E. Cosler, Michael R. Gionfriddo, Emily E. Leppien, Eleanor J. Sommers, Mia E. Lussier   +5 more
wiley   +1 more source

The Effect of Canagliflozin Dose on Renal and Cardiovascular Outcomes in Type 2 Diabetes and High Cardiovascular Risk

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Pharmacokinetic data suggest a potential dose‐dependent effect of sodium–glucose co‐transporter‐2 (SGLT‐2) inhibitors on surrogate markers of efficacy, but the impact of SGLT‐2 inhibitor dose on renal and cardiovascular outcomes remains uncertain.
Elias John Elenjickal, Frédéric Baroz, Philippe Boileau, Michael A. Tsoukas, Abhinav Sharma, Thomas A. Mavrakanas   +5 more
wiley   +1 more source

The Sulfonylurea Glimepiride Regulates Intracellular Routing of the Insulin-Receptor Complexes through Their Interaction with Specific Protein Kinase C Isoforms

, 2020
Sulfonylureas may stimulate glucose metabolism by protein kinase C (PKC) activation. Because interaction of insulin receptors with PKC plays an important role in controlling the intracellular sorting of the insulin-receptor complex, we investigated the ...
Renato Federici, Lauro, Patrizia Liu, Giorgio Lauro, Barbara Rossella D'alfonso, Sesti, Y U Yong, Massimo Borboni, Marta Letizia Hribal, Davide Giovannone   +9 more
core  

GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To provide a comprehensive overview of the cardiovascular and renal effects of glucose‐dependent insulinotropic polypeptide (GIP) by integrating its physiological role with recent human trial data on tirzepatide, the first dual GIP and glucagon‐like peptide‐1 (GLP‐1) receptor agonist.
Michelantonio De Fano, Line L. Haurum, Christine R. Schwarz, Francesca Porcellati, Andreas Andersen   +4 more
wiley   +1 more source

[Sulfonylurea receptors and their interaction with glimepiride].

Likars'ka sprava, 2003
In the review, data are presented on glymepiride (amaril), a 3-d generation sulphanylamide. The drug interacts with receptors to sulphonylurea--SUR X, that are found only in B-cells of the pancreas, which fact has been shown to be associated with a higher secretion of insulin, an increased sensitivity of peripheral tissues to this hormone and with ...
N A, Zueva, N V, Sologub, A S, Efimov
openaire   +1 more source