Results 91 to 100 of about 18,742 (250)

The sulfonylurea receptor

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1992
Ashcroft, S, Ashcroft, F
openaire   +2 more sources

Do the treatment selection factors emphasized in clinical guidelines—Chronic kidney disease, cardiovascular disease, and heart failure—contribute to the risk of urinary tract infections during the administration of sodium‐glucose cotransporter‐2 inhibitors?

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction Sodium‐glucose cotransporter‐2 inhibitors (SGLT2Is) are recommended in Japan for patients with cardiovascular disease (CVD), heart failure (HF), or chronic kidney disease (CKD) due to their organ‐protective effects, leading to increased use in high‐risk populations.
Takuma Koinuma, Manato Yoshida, Manabu Akazawa   +2 more
wiley   +1 more source

The impact of sulfonylureas on diverse ion channels: an alternative explanation for the antidiabetic actions

Frontiers in Cell and Developmental Biology
The oral hypoglycemic drug sulfonylureas exhibit substantial therapeutic benefits for millions of patients with type 2 diabetes mellitus (T2DM), although with common adverse effects, such as hypoglycemia.
Xian-Tao Li, Meng-Ze Yun
doaj   +1 more source

Associations of skeletal muscle mass and strength with arterial stiffness in type 2 diabetes

Journal of Diabetes Investigation, EarlyView.
Lower skeletal muscle mass and lower handgrip strength were associated with higher arterial stiffness in individuals with type 2 diabetes. Assessment of both parameters may provide complementary information regarding vascular risk. ABSTRACT Sarcopenia is prevalent in people with type 2 diabetes mellitus (T2DM) and may contribute to increased ...
Naoki Koike, Yoko Irie, Yuji Doi, Ryosuke Kemmotsu, Moe Kusushita, Yasuna Sakai, Tomonori Okita, Hiroyuki Sho, Ryoko Inui, Yukiko Tabuchi, Tetsuyuki Yasuda   +10 more
wiley   +1 more source

Understanding Knowledge, Attitude, and Perception of Indian Clinicians in the Management of Resource-challenged Type 2 Diabetes Mellitus Patients in India - DESERVE India Expert Opinion: Part 1

Chronicle of Diabetes Research and Practice
Introduction: Type 2 diabetes mellitus (T2DM), once perceived as a condition prevalent among affluent elderly urban residents, now affects a more diverse demographic, including populations from less-privileged and rural communities.
Ambika G. Unnikrishnan, Abji B. Patel, Alagarsamy Kannan, Ananda Bagchi, Bashir A. Laway, Chandrasekar Selvaraj, Debmalya Sanyal, Deep Dutta, Dipanjan Bandyopadhyay, Gopinath R. Chilakala, Jaydeep S. Shinde, Jimit Vadgama, Kora Chandra O. Reddy, Kunal Kundan, Manoj Chitle, Om Lakhani, Praveen K. Devarbhavi, Ragini Bhake, Rajesh Deshmane, Sadashivappa Chandrashekar, Senthil Kumar, Sunil K. Kota, Vyankatesh Shivane, Vaithi G. Subramaniyan, Santosh Y. Revankar   +24 more
doaj   +1 more source

Waist‐to‐height ratio and renal dysfunction as independent correlates of low handgrip strength in patients with type 2 diabetes

Journal of Diabetes Investigation, EarlyView.
In 1,468 patients with type 2 diabetes, central obesity (WHtR >0.5) neutralizes the protective effects of higher BMI on muscle strength. Concurrently, visceral adiposity and CKD impose an additive threat, maximizing low handgrip strength risk (aOR = 1.74). Combining WHtR and renal tracking optimizes clinical sarcopenia screening.
Shing‐Hua Chen, Chen‐Kai Chou, Shao‐Wen Weng, Jung‐Fu Chen, Feng‐Chih Shen   +4 more
wiley   +1 more source

Clinical characteristics of Sarcopenic obesity in Japanese people with type 2 diabetes: A post hoc analysis of the sub‐cohort iDIAMOND study

Journal of Diabetes Investigation, EarlyView.
Among participants aged 40–75 years, sarcopenic obesity was observed in 4.9% of those with T2D and 0.5% of non‐D individuals. Sarcopenic obesity is more prevalent in individuals with T2D and is associated with impaired physical QOL, reduced walking ability, and increased falls.
Hiroyasu Mori, Kasei Ko, Satoko Notomi, Sumiko Yoshida, Tetsuyuki Yasuda, Yutaka Umayahara, Sayoko Shimizu, Kayoko Ryomoto, Kazutomi Yoshiuchi, Saeko Osawa, Tsunehiko Yamamoto, Akio Kuroda, Munehide Matsuhisa   +12 more
wiley   +1 more source

Sodium zirconium cyclosilicate compared with potassium restriction for hyperkalemia management in type 2 diabetes: The SILVERSTAR trial

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction To demonstrate noninferiority of continued sodium zirconium cyclosilicate therapy versus a potassium‐restricted diet in achieving normokalemia at Visit 7 (Days 28–42) in individuals with type 2 diabetes and hyperkalemia, using a noninferiority margin of −10 percentage points (one‐sided α = 0.025).
Masahide Hamaguchi, Junya Hironaka, Hiroshi Okada, Mari Yoneda, Ayaka Kobayashi, Yoshitaka Hashimoto, Aya Kitae, Noriyuki Kitagawa, Akio Kishi, Michiyo Ishii, Mai Asano, Masahiro Yamazaki, Toru Tanaka, Hanako Nakajima, Eiko Sato, Michiaki Fukui   +15 more
wiley   +1 more source

Diagnostic performance of SD‐ΔRR during physical stressors for identifying diabetic sensorimotor polyneuropathy

Journal of Diabetes Investigation, EarlyView.
Study population, methodology and key findings of the study. ABSTRACT Aims This study aimed to evaluate the clinical efficacy of SD‐ΔRR as a novel methodology for short‐duration heart rate variability (HRV) assessment for the diagnosis of diabetic sensorimotor polyneuropathy (DSPN) in patients with diabetes.
Katsuyoshi Katayama, Haruhito A. Uchida, Toshihiko Nagao, Jun Eguchi, Kenji Tsuji, Yoshinori Matsumoto, Ichiro Nojima, Keiko Tanaka, Hidemi Takeuchi, Yasuhiro Onishi, Rika Takemoto, Satoshi Miyamoto, Kenichi Shikata, Jun Wada   +13 more
wiley   +1 more source

Resistências cruzadas em biótipos de Alisma Plantago-Aquatica resistentes ao bensulfurão-metilo e suas consequências Cross resistance in bensulfuron-methyl resistant Alisma Plantago-Aquatica biotypes

Revista de Ciências Agrárias, 2008
A aplicação repetida de bensulfurão-metilo em arrozais dos vales dos rios Sorraia, Sado e Mondego seleccionaram populações resistentes (R) de Alisma plantago-aquatica (Mo260, Sa88, So306 e So307). Determinou-se o nível de resistência (NR= ED50 R/ ED50 S)
Isabel M. Calha, Ilídio Moreira, Fátima Rocha   +2 more
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