Results 121 to 130 of about 29,600 (252)

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

The Integrative Role of Sulforaphane in Preventing Inflammation, Oxidative Stress and Fatigue: A Review of a Potential Protective Phytochemical

Antioxidants, 2020
Cruciferous vegetables hold a myriad of bioactive molecules that are renowned for possessing unique medicinal benefits. Sulforaphane (SFN) is one of the potential nutraceuticals contained within cruciferous vegetables that is useful for improving health ...
Ruheea Taskin Ruhee, Katsuhiko Suzuki
semanticscholar   +1 more source

Impact of Endothelial Diversity and Dysfunction on Cardiovascular Disease

Comprehensive Physiology, Volume 15, Issue 6, December 2025.
The vascular endothelium is highly diverse, regulating permeability, vascular tone, repair, and inter‐organ communication. Endothelial heterogeneity supports tissue‐specific needs, but dysfunction drives cardiovascular disease. Transcriptomics, in vitro models, and redox signaling studies reveal therapeutic targets for precision treatment of ...
Anna E. Williams, Luke S. Dunaway, Zuzanna J. Juśkiewicz, Wyatt J. Schug, Miriam M. Cortese‐Krott, Michael Koval, Brant E. Isakson   +6 more
wiley   +1 more source

Mining Actinomycetes' Metabolomes and Genomes for Anti‐Phytophthora infestans Compounds

Microbial Biotechnology, Volume 18, Issue 12, December 2025.
Using a comparative metabolomic and genomic approach on 63 actinomycetes, this study identified 75 compounds associated with the strains' ability to inhibit the late blight‐causing agent Phytophthora infestans. This study highlighted the promise of applying multi‐omics techniques on closely related strains differing in biological activity to pinpoint ...
Ola Abdelrahman, Quinn Coxon, Eliane Abou‐Mansour, Floriane L'Haridon, Laurent Falquet, Pierre‐Marie Allard, Laure Weisskopf   +6 more
wiley   +1 more source

Ignoring the planet: A critical blind spot for research on ageing

Journal of Internal Medicine, Volume 298, Issue 6, Page 578-590, December 2025.
Abstract Although research on ageing has largely concentrated on understanding the fundamental biology of the ageing process and devising pharmaceutical interventions in order to slow it down, increasing evidence has underscored the crucial role of environmental inputs across the life course and across generations, in shaping both individual and ...
Paul Shiels, Ognian Neytchev, Gillian Borland, Polina Germushkina, Richard Johnson, Peter Stenvinkel, Tina Woods   +6 more
wiley   +1 more source

Cancer Prevention and Therapy With Nutritional Science: Addressing the Gap in Medical Education and Practice

MedComm, Volume 6, Issue 11, November 2025.
A plant‐based diet reduces the risk of cancer by providing essential nutrients and phytochemicals that contain anticancer properties. Osteopathic medicine's holistic approach emphasizes the interconnectedness of body systems and lifestyle factors, including nutrition, to promote overall health and prevent disease.
Taylor E. Collignon, Anupam Bishayee
wiley   +1 more source

Sulforaphane Attenuates Endometriosis in Rat Models Through Inhibiting PI3K/Akt Signaling Pathway

Dose-Response, 2019
Sulforaphane exerts anti-inflammatory activity in inflammatory diseases. The endometriosis (EM) is accompanied by chronic inflammation. The present study aims to explore the therapeutic effects of sulforaphane on EM and its underlying mechanism.
Aixiu Zhou, Yiting Hong, Yuchun Lv
doaj   +1 more source

Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells [PDF]

, 2017
Silybum marianum (milk thistle) is a medicinal plant used for the treatment of various liver disorders. This study examined whether the main flavonolignans from S. marianum (i.e.
Abenavoli, Albena T. Dinkova-Kostova, Baird, Begum, Biedermann, Biedermann, Bonifaz, Borsari, Chambers, Chow, David Biedermann, Dinkova-Kostova, Dvorak, Dzubak, Fahey, Federico, Feher, Gazak, Gazak, Hayes, Jitka Ulrichová, Jiří Vrba, Krenek, Lenka Roubalová, Liang, Nioi, Prochazkova, Pyszkova, Roubalova, Surai, Tanigawa, Thongphasuk, Trouillas, Varga, Vladimír Křen, Vrba, Wang, Zhan, Zhang, Zhao   +39 more
core   +2 more sources

Monovalent glycoconjugates of sulforaphane prevent inflammation induced by lipopolysaccharide in human dendritic cells by inhibiting NF‐ĸB signalling pathway

British Journal of Pharmacology, Volume 182, Issue 21, Page 5157-5172, November 2025.
Background and Purpose Sulforaphane (SFN) has notable health benefits but faces challenges due to its poor solubility and delivery. This study investigates SFN‐glycoconjugates effects on lipopolysaccharide (LPS)‐induced inflammation in dendritic cells (DCs). With the aiming to enhance their therapeutic potential against inflammatory diseases.
Camila Leiva‐Castro, Ana Maria Múnera‐Rodríguez, Macarena Martínez‐Bailén, Ana Teresa Carmona, Soledad López‐Enríquez, Francisca Palomares   +5 more
wiley   +1 more source

PINGing Sunshine: A Review of the Evidence for Adding Non‐Filtering Photoprotective Ingredients to Sunscreens

Photodermatology, Photoimmunology &Photomedicine, Volume 41, Issue 6, November 2025.
ABSTRACT Background Photoprotective INGredients (PINGs) are non‐filtering agents that enhance the skin's intrinsic defenses against solar radiation. Acting through antioxidant, DNA repair, immunomodulatory, anti‐inflammatory, and pigmentation‐regulating mechanisms, PINGs may prevent or repair photodamage.
Jean Krutmann, Anthony Brown, Thierry Passeron, Corinne Granger, Yolanda Gilaberte, Carles Trullas, Jaime Piquero‐Casals, Giovanni Leone, Sergio Schalka, Henry W. Lim   +9 more
wiley   +1 more source