Results 161 to 170 of about 29,796 (299)

Network Pharmacology Approach to Explore the Skin‐Lightening Compounds and Potential Mechanisms of Chinese Herbal Medicines

Journal of Cosmetic Dermatology, Volume 24, Issue 12, December 2025.
ABSTRACT Introduction Herbal formulations have been used for skin whitening in China for centuries, yet systematic evaluations of their efficacy and underlying mechanisms remain limited. This study aims to identify potential anti‐melanogenic compounds in traditional skin‐whitening herbs using network pharmacology and investigate their mechanisms of ...
Yixuan Liang, Jing Chen, Chuhan Fu, Xixia Dai, Ling Jiang, Xinxin Lei   +5 more
wiley   +1 more source

Anticancer activity of sulforaphane against human hepatoblastoma cells involves apoptosis, autophagy and inhibition of β-catenin signaling pathway

Archives of Medical Science, 2020
Introduction Sulforaphane is an active isothiocyanate and has been reported to exhibit many pharmacological and biological activities including anticancer activity.
Junshan Lin, Yali Xu, Xing Zhao, Zhixin Qiu   +3 more
doaj   +1 more source

Ignoring the planet: A critical blind spot for research on ageing

Journal of Internal Medicine, Volume 298, Issue 6, Page 578-590, December 2025.
Abstract Although research on ageing has largely concentrated on understanding the fundamental biology of the ageing process and devising pharmaceutical interventions in order to slow it down, increasing evidence has underscored the crucial role of environmental inputs across the life course and across generations, in shaping both individual and ...
Paul Shiels, Ognian Neytchev, Gillian Borland, Polina Germushkina, Richard Johnson, Peter Stenvinkel, Tina Woods   +6 more
wiley   +1 more source

The pharmacological regulation of cellular mitophagy [PDF]

, 2017
Small molecules are pharmacological tools of considerable value for dissecting complex biological processes and identifying potential therapeutic interventions.
A Brunet, A Cassidy-Stone, A Hoshino, A Hoshino, A Jain, A Kazlauskaite, A Khaminets, A Managò, A Orvedahl, A Sargsyan, A Schiavi, AE Alekseev, AT Dinkova-Kostova, AY Amerik, B Arun, B Bingol, B Maro, BJ Gurd, BM Kenwood, BS Padman, C Jo, C Jo, C Kondapalli, C Zhang, CA da Costa, CN Cunningham, CT Chu, D Liu, D Narendra, D Narendra, DA East, DA East, DP Narendra, EA Liberman, EF Fang, EH Kim, EH Kim, F Gao, F Ivanes, G Ashrafi, G Bellot, G Chen, G Wells, Geoff Wells, GFG Allen, GL McLelland, H Jia, H Sandoval, H Wei, H Zhang, HC Bertrand, HT Kang, I Kim, I Novak, IH Lee, J Gatliff, J Gatliff, J H Zhu, J Li, J Viotti, J Yun, J-H Zhu, JR Jangamreddy, K Grenier, K-S Park, KKK Chung, KM Holmström, L Liu, M Frank, M Fu, M Lazarou, M Mauro-Lizcano, M Mogi, M Redmann, Michelangelo Campanella, MV Tsiper, NA Khan, ND Georgakopoulos, Nikolaos D Georgakopoulos, NT Hertz, NV Kirienko, P Bai, Q Shen, R Huang, R Rupprecht, RD Sentelle, RJ Youle, RK Dagda, S Givvimani, S Kume, S Melser, S Rikka, SA Hasson, SJ Park, SM Jin, SY Jang, TM Durcan, W Duan, W Yue, X Qi, Y Kageyama, Y Wang, YP Yang, YQ Liu   +103 more
core   +4 more sources

Sulforaphane Prevents Colitis-associated Cancer by Inducing Phase II Enzymes Activity of Liver Detoxification [PDF]

, 2011
Ulcerative colitis (UC) is a kind of Inflammatory Bowel Disease (IBD) characterized by chronic inflammation that causes ulceration of the colonic mucosa and extends proximally from the rectum into the colon.
Darsono, L. (Lusiana), Khiong, K. (Khie), Yolanda, R. (Raissa)   +2 more
core  

Contents of sulforaphane and total isothiocyanates, antimutagenic activity, and inhibition of clastogenicity in pulp

Czech Journal of Food Sciences, 2011
The consumption of Cruciferous vegetables is important for the prevention of cancerous diseases, particularly colorectal cancer. The effects of technological treatments (freezing, pasteurisation, high-pressure treatment) on the content of isothiocyanates,
Jiří Totušek, Jan Tříska, Danuše Lefnerová, Jan Strohalm, Naděžda Vrchotová, Ondřej Zendulka, Jiřina Průchová, Jana Chaloupková, Pavla Novotná, Milan Houška   +9 more
doaj   +1 more source

Friend and foe: factors influencing the movement of the bacterium Helicobacter pylori along the parasitism-mutualism continuum. [PDF]

, 2014
Understanding the transition of bacterial species from commensal to pathogen, or vice versa, is a key application of evolutionary theory to preventative medicine.
Koskella, Britt, Lin, Derek
core   +1 more source

Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1 [PDF]

, 2014
Aflatoxin B[subscript 1] (AFB[subscript 1]) is one of the major risk factors for liver cancer globally. A recent study showed that sulforaphane (SF), a potent inducer of phase II enzymes that occurs naturally in widely consumed vegetables, effectively ...
Croy, Robert G, Essigmann, John M, Fiala, Jeanette LouiseAllen, Groopman, John D., Navasumrit, Panida, Ruchirawat, Mathuros, Techapiesancharoenkij, Nirachara, Wogan, Gerald N   +7 more
core   +1 more source

Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways

Acta Pharmaceutica Sinica B, 2021
Xiang Wang, Xinxin Chen, Wenqian Zhou, Hongbo Men, Terigen Bao, Yike Sun, Quanwei Wang, Yi Tan, B. Keller, Qian Tong, Yang Zheng, L. Cai   +11 more
semanticscholar   +1 more source

Sulforaphane as a Promising Molecule for Fighting Cancer

, 2013
Cancer is a complex disease characterized by multiple genetic and molecular alterations involving transformation, deregulation of apoptosis, proliferation, invasion, angiogenesis, and metastasis. To grow, invade, and metastasize, tumors need host components and primary dysfunction in the tumor microenvironment, in addition to cell dysfunction, can be ...
LENZI, MONIA, FIMOGNARI, CARMELA, HRELIA, PATRIZIA   +2 more
openaire   +2 more sources