Results 11 to 20 of about 25,287 (258)

Monovalent mannose‐glycoconjugates of sulforaphane reprogram human dendritic cells via NFATc1 to induce immune tolerance under inflammatory conditions

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Immune tolerance prevents inflammation and autoimmunity, with dendritic cells (DCs) playing a key role. Reprogramming DCs towards a tolerogenic state represents a promising therapeutic strategy. Sulforaphane (SFN) has known immunomodulatory effects, but its clinical application is limited by poor stability and ...
María Elena Angarita-Planchez, Camila Leiva‐Castro, Ana Maria Múnera‐Rodríguez, Macarena Martínez‐Bailén, Ana T. Carmona, Soledad López-Enríquez, Francisca Palomares   +6 more
openalex   +2 more sources

Sulforaphane and ophthalmic diseases [PDF]

Food Science & Nutrition
AbstractSulforaphane (SFN) is an organosulfur compound categorized as an isothiocyanate (ITC), primarily extracted from cruciferous vegetables like broccoli and cabbage. The molecular formula of sulforaphane (SFN) is C6H11NOS2. SFN is generated by the hydrolysis of glucoraphanin (GRP) through the enzyme myrosinase, showing notable properties including ...
Yichi Zhang, Xiaojing Zhao, Yang Liu, Xiuxia Yang   +3 more
openaire   +3 more sources

Multi-targeted prevention of cancer by sulforaphane [PDF]

Cancer Letters, 2008
Isothiocyanates are found in cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage. Epidemiologic studies suggest that cruciferous vegetable intake may lower overall cancer risk, including colon and prostate cancer. Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables and is especially high in broccoli ...
Clarke, John D, Dashwood, Roderick H, Ho, Emily   +2 more
openaire   +5 more sources

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder [PDF]

, 2020
Autism Spectrum Disorder (ASD) is one of the most common neurodevelopmental disorders with no drugs treating the core symptoms and no validated biomarkers for clinical use.
Connors, Susan L., Diggins, Eileen, Dinkova-Kostova, Albena, Fahey, Jed W., Liu, Hua, Singh, Kanwaljit, Stephenson, Katherine K., Zimmerman, Andrew W.   +7 more
core   +3 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Influence of sequential exogenous pretreatment and contact ultrasound-assisted air drying on the metabolic pathway of glucoraphanin in broccoli florets

Ultrasonics Sonochemistry, 2022
In this investigation, the combinations of exogenous pretreatment (melatonin or vitamin C) and contact ultrasound-assisted air drying were utilized to dry broccoli florets. To understand the influences of the studied dehydration methods on the conversion
Beini Liu, Yang Tao, Sivakumar Manickam, Dandan Li, Yongbin Han, Ying Yu, Dongfeng Liu   +6 more
doaj   +1 more source

Benefits and risks of the hormetic effects of dietary isothiocyanates on cancer prevention [PDF]

, 2014
The isothiocyanate (ITC) sulforaphane (SFN) was shown at low levels (1-5 µM) to promote cell proliferation to 120-143% of the controls in a number of human cell lines, whilst at high levels (10-40 µM) it inhibited such cell proliferation.
A Arlt, A Giudice, A Herman-Antosiewicz, A Lau, A Lister, A Melchini, A Speciale, AA Alfadda, AJ Vargas, AT Dinkova-Kostova, AV Gasper, C Cornelius, C Fimognari, C Fimognari, Changhao Sun, CR Zhao, D Li, D Rand, D Ren, Daotai Nie, DD Zhang, DS Michaud, E Warwick, EJ Calabrese, EJ Calabrese, EJ Calabrese, EJ Calabrese, ER Hahm, F Ekiz, F Galgano, F Zanichelli, GM DeNicola, GR Fenwick, GS Omenn, HK Na, I Misiewicz, I Oehme, IS Santos, J Jakubikova, J Watson, JD Clarke, JD Hayes, JD Watson, JM Cramer, K Pietsch, K Suppipat, KA Moy, KL Cheung, L Gamet-Payrastre, L Kuang, L Ye, LN Barrera, LS Cooley, M McMahon, MB Sporn, MP Mattson, MP Mattson, P Sestili, P Shelton, PE Miller, R Brigelius-Flohe, RF Clayton, RK Thimmulappa, S Homma, SA McNaughton, SJ Jackson, SL Navarro, T Hara, T Nishikawa, T Xu, TG Son, TW Kensler, TW Kensler, V Calabrese, V Rungapamestry, W Hendrickx, Wei Wang, X Ma, X Yu, XJ Wang, Y Ji, Y Li, Y Mitsuishi, Y Shan, Y Zhang, Y Zhang, Y Zhang, Y Zhang, YJ Surh, Yongping Bao, YS Keum, Zhigang Zhou   +91 more
core   +6 more sources

Measuring Sulforaphane and Its Metabolites in Human Plasma: A High Throughput Method

Molecules, 2020
(1) Background: There is increasing understanding of the potential health benefits of cruciferous vegetables. In particular sulforaphane (SFN), found in broccoli, and its metabolites sulforaphane-glutathione (SFN-GSH), sulforaphane-cysteine (SFN-Cys ...
Annie Langston-Cox, Dovile Anderson, Darren J. Creek, Kirsten Palmer, Euan M. Wallace, Sarah A. Marshall   +5 more
doaj   +1 more source

Sulforaphane attenuates dextran sodium sulphate induced intestinal inflammation via IL-10/STAT3 signaling mediated macrophage phenotype switching

Food Science and Human Wellness, 2022
Innate immunity, particularly macrophages, is critical for intestinal homeostasis. Sulforaphane, a dietary isothiocyanate from cruciferous vegetables, has been reported to protect against intestinal inflammation.
Yuyang Sun, Jiqing Tang, Cui Li, Jun Liu, Haijie Liu   +4 more
doaj   +1 more source

Comparison of Pharmacokinetics and Anti-Pulmonary Fibrosis-Related Effects of Sulforaphane and Sulforaphane N-acetylcysteine [PDF]

Pharmaceutics, 2021
Sulforaphane (SFN), belonging to the isothiocyanate family, has received attention owing to its beneficial activities, including chemopreventive and antifibrotic effects. As sulforaphane N-acetylcysteine (SFN-NAC), a major sulforaphane metabolite, has presented similar pharmacological activities to those of SFN, it is crucial to simultaneously analyze ...
Eun Suk Son, Xiang Fei, Jin-Ha Yoon, Seung-Yong Seo, Han-Joo Maeng, Sung Hwan Jeong, Yu Chul Kim   +6 more
openaire   +3 more sources