Results 11 to 20 of about 50 (50)
Stimulation of Suicidal Erythrocyte Death by Sulforaphane [PDF]
Basic & Clinical Pharmacology & Toxicology, 2014 AbstractSulforaphane, an isothiocyanate from cruciferous vegetable, counteracts malignancy. The effect is at least in part due to the stimulation of suicidal death or apoptosis of tumour cells. Mechanisms invoked in sulforaphane‐induced apoptosis include mitochondrial depolarization and altered gene expression.
Caterina Faggio +4 more
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Kinetics of sulforaphane in mice after consumption of sulforaphane‐enriched broccoli sprout preparation [PDF]
Molecular Nutrition & Food Research, 2013 ScopeSulforaphane (SF) is a natural isothiocyanate in broccoli sprouts with cancer chemopreventive activity. This study is aimed to use different methods to develop broccoli sprout preparations to compare their ability to deliver SF to the mice and to evaluate the kinetics and biodistribution of SF.Methods and resultsThe SF‐enriched sprout preparation ...
Duxin Sun +7 more
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Interaction of Sulforaphane with DNA and RNA
PLOS ONE, 2015 Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables with anti-inflammatory, anti-oxidant and anti-cancer activities. However, the antioxidant and anticancer mechanism of sulforaphane is not well understood. In the present research, we reported binding modes, binding constants and stability of SFN-DNA and -RNA complexes by Fourier ...
Faramarz Yari +3 more
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Sulforaphane is anticonvulsant and improves mitochondrial function [PDF]
Journal of Neurochemistry, 2015 AbstractThe nuclear factor erythroid 2‐related factor 2 pathway (Nrf2) has been previously identified to protect the brain against various impacts. Here, we investigated the effect of the Nrf2 activator sulforaphane in various seizure models and hippocampal mitochondrial bioenergetics.
Catalina Carrasco-Pozo +3 more
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Multi-targeted prevention of cancer by sulforaphane [PDF]
Cancer Letters, 2008 Isothiocyanates are found in cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage. Epidemiologic studies suggest that cruciferous vegetable intake may lower overall cancer risk, including colon and prostate cancer. Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables and is especially high in broccoli ...
Clarke, John D +2 more
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Sulforaphane and ophthalmic diseases
Food Science & NutritionAbstractSulforaphane (SFN) is an organosulfur compound categorized as an isothiocyanate (ITC), primarily extracted from cruciferous vegetables like broccoli and cabbage. The molecular formula of sulforaphane (SFN) is C6H11NOS2. SFN is generated by the hydrolysis of glucoraphanin (GRP) through the enzyme myrosinase, showing notable properties including ...
Yichi Zhang +3 more
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POTENTIAL USE OF SULFORAPHANE AS A NEUROPROTECTOR
Medical and Clinical Chemistry, 2021 Introduction. Under normal conditions, oxidative stress and proinflammatory processes are tightly controlled. However, during neuroinflammation and overproduction of reactive oxygen species (ROS), homeostasis is disrupted, which may lead to development of Alzheimer’s disease, Parkinson’s disease and other neurodegenerative disorders.
K. M. Starchevska +2 more
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Sulforaphane as a promising molecule for fighting cancer [PDF]
Mutation Research/Reviews in Mutation Research, 2007 A number of natural compounds with inhibitory effects on tumorigenesis have been identified from our diet. Several studies have documented the cancer-preventive activity of a significant number of isothiocyanates (ITCs), the majority of which occur in plants, especially in Cruciferous vegetables. The most characterized ITC is sulforaphane (SFN).
FIMOGNARI, CARMELA, HRELIA, PATRIZIA
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Sulforaphanes: disruptors of phagophores and autolysosomes
Autophagy Reports, 2022 Sulforaphane and its metabolites (SFNs) cause apoptosis in cancers and could be potential anti-cancer drugs. We focused on investigating the underlying mechanisms through which SFNs inhibit cancers. First, SFNs cause microtubule disruption by phosphorylated MAPK1/ERK2-MAPK3/ERK1-mediated activation of 26S proteasome leading to a microtubule-associated ...
Yan Zhou, Wei Wu
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Current potential health benefits of sulforaphane
EXCLI journal, 2016 EXCLI Journal; 15:Doc571; ISSN 1611 ...
Kim, Jae Kwang, Park, Sang Un
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