Results 31 to 40 of about 14,451 (212)

Sulforaphanes: disruptors of phagophores and autolysosomes

Autophagy Reports, 2022
Sulforaphane and its metabolites (SFNs) cause apoptosis in cancers and could be potential anti-cancer drugs. We focused on investigating the underlying mechanisms through which SFNs inhibit cancers. First, SFNs cause microtubule disruption by phosphorylated MAPK1/ERK2-MAPK3/ERK1-mediated activation of 26S proteasome leading to a microtubule-associated ...
Yan Zhou, Wei Wu
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Sulforaphane in experimental hypertension

Libyan International Medical University Journal, 2020
Abstract Background: Hypertension is defined as a failure to achieve a blood pressure (BP) target – smaller than 140/90 mmHg. The worldwide burden of hypertension has been associated with globally increased rates of death and disability. There is increasing evidence of strong relation between hypertension and oxidative stress, where either ...
Ali Banigesh, Vijitha Senanayake, Salma Bukhatwa, Bernhard Juurlink   +3 more
openaire   +2 more sources

Stability of sulforaphane for topical formulation [PDF]

Drug Development and Industrial Pharmacy, 2013
Sulforaphane (SFN) is a natural compound that has been investigated as a chemopreventive agent. SFN has been shown to inhibit the activator-protein-1 (AP-1) transcription factor and may be effective for inhibition of ultraviolet (UV) induced skin carcinogenesis.
Stephen J, Franklin, Sally E, Dickinson, Kelly L, Karlage, G T, Bowden, Paul B, Myrdal   +4 more
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Quantitative determination of sulforaphane from broccoli extract tablets and its role in the protection of acute liver injury induced by ethanol

浙江大学学报. 农业与生命科学版, 2013
Sulforaphane (SFN) is an isothiocyanate (ITC) which exists as a precursor of glucosinolate (GS) in various cruciferous vegetables especially in broccoli. Sulforaphane has been regarded as a potential of anti-cancer agent derived from diet, mostly because
LI Baolong, TIAN Sicong, TAN Jie, LI Bing, CHEN Jingyu, SHAN Yujuan   +5 more
doaj   +1 more source

Exploring the anti‐inflammatory activity of sulforaphane

Immunology & Cell Biology, 2023
AbstractDysregulation of innate immune responses can result in chronic inflammatory conditions. Glucocorticoids, the current frontline therapy, are effective immunosuppressive drugs but come with a trade‐off of cumulative and serious side effects. Therefore, alternative drug options with improved safety profiles are urgently needed.
Katie Treasure, James Harris, Gary Williamson   +2 more
openaire   +3 more sources

Sulforaphane - role in aging and neurodegeneration [PDF]

GeroScience, 2019
In the last several years, numerous molecules derived from plants and vegetables have been tested for their antioxidant, anti-inflammatory, and anti-aging properties. One of them is sulforaphane (SFN), an isothiocyanate present in cruciferous vegetables.
Santín-Márquez R., Alarcón-Aguilar A., López-Diazguerrero N.E., Königsberg M., Chondrogianni, Niki   +4 more
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Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma [PDF]

BMB Reports, 2012
Sulforaphane (1-isothiocyanato-4-(methylsulfinyl)-butane), belongingto a family of natural compounds that are abundant in broccoli,has received significant therapeutic interest in recent years.However, the molecular basis of its effects remains to ...
Jun Ho Park, Jong Won Kim, Chang-Min Lee, Yeong Dae Kim, Sung Woon Chung, In Duk Jung, Kyung Tae Noh, Jin Wook Park, Deok Rim Heo, Yong Kyoo Shin, Jong Keun Seo, Yeong-Min Park   +11 more
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Anticancer properties of sulforaphane: current insights at the molecular level

Frontiers in Oncology, 2023
Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature ...
Muhammad Asif Ali, Noohela Khan, Nabeeha Kaleem, Waqas Ahmad, Salem Hussain Alharethi, Bandar Alharbi, Hassan H. Alhassan, Maher M. Al-Enazi, Ahmad Faizal Abdull Razis, Ahmad Faizal Abdull Razis, Babagana Modu, Babagana Modu, Daniela Calina, Javad Sharifi-Rad   +13 more
doaj   +1 more source

Stimulation of Suicidal Erythrocyte Death by Sulforaphane [PDF]

Basic & Clinical Pharmacology & Toxicology, 2014
AbstractSulforaphane, an isothiocyanate from cruciferous vegetable, counteracts malignancy. The effect is at least in part due to the stimulation of suicidal death or apoptosis of tumour cells. Mechanisms invoked in sulforaphane‐induced apoptosis include mitochondrial depolarization and altered gene expression.
Alzoubi K., Calabrò S., FAGGIO, Caterina, Lang F.   +3 more
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Glucoraphanin conversion into sulforaphane and related compounds by gut microbiota

Frontiers in Physiology
Glucosinolate glucoraphanin, common in cruciferous vegetables, is a biologically stable precursor of isothiocyanates, such as sulforaphane and erucin, potent activators of Nrf2 signaling coordinating an adaptive response to oxidative stress. Sulforaphane
Tetiana R. Dmytriv, Tetiana R. Dmytriv, Oleh Lushchak, Oleh Lushchak, Volodymyr I. Lushchak, Volodymyr I. Lushchak   +5 more
doaj   +1 more source