Results 31 to 40 of about 50 (50)

Antileukemic Activity of Sulforaphane

2016
The biological complexity of cancer offers numerous targets for antineoplastic therapies. Diet is a common source of biologically active compounds. Many studies demonstrated an inverse relation between the consumption of vegetables and the risk of cancer.
CATANZARO, ELENA, FIMOGNARI, CARMELA
openaire   +1 more source

Synergistic Effect of Combination of Phenethyl Isothiocyanate and Sulforaphane or Curcumin and Sulforaphane in the Inhibition of Inflammation

Pharmaceutical Research, 2008
Accumulating evidence from epidemiologic and clinical studies indicates that chronic inflammatory disorders harbor an increased risk of cancer development. Curcumin (CUR) has been strongly linked to the anti-inflammatory effect. On the other hand, isothiocyanates such as sulforaphane (SFN) and phenethyl isothiocyanate (PEITC) are strong phase-II ...
Ka Lung Cheung, Tin Oo Khor, Ah-Ng Tony Kong   +2 more
openaire   +3 more sources

Theoretical investigation of sulforaphane molecule

Journal of Molecular Structure: THEOCHEM, 2005
The structural and electronic properties of the broccoli sulforaphane molecule have been investigated theoretically by performing semi-empirical molecular orbital (PM3) and density functional theory calculations. The geometry of the molecule has been optimized by PM3 method and the electronic properties and the vibrational spectra of the molecule have ...
Erkoc, S, Erkoc, F
openaire   +3 more sources

Approaches for enhancing the stability and formation of sulforaphane

Food Chemistry, 2021
The isothiocyanate sulforaphane (SF) is one of the most potent naturally occurring Phase 2 enzymes inducers derived from brassica vegetables like broccoli, cabbage, brussel sprouts, etc. Ingestion of broccoli releases SF via hydrolysis of glucoraphanin (GRP) by plant myrosinase and/or intestinal microbiota.
Wu Yuanfeng, Mao Jianwei, Sun Juan, Lv Chengzhi, Zou Ligen, Zhang Yao, Song Xinjie   +6 more
openaire   +2 more sources

Thermal Degradation of Sulforaphane in Aqueous Solution

Journal of Agricultural and Food Chemistry, 1999
Sulforaphane, a cancer chemopreventive agent identified from broccoli, was degraded in an aqueous solution at 50 and 100 degrees C. The reaction mixtures were extracted with methylene chloride and analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS).
Rosen, RT, Jin, Y, Wang, M, Ho, CT
openaire   +5 more sources

Evolution of sulforaphane content in sulforaphane-enriched broccoli during tray drying

Journal of Food Engineering, 2016
Abstract Sulforaphane is a natural anticancer compound found in broccoli that comes from hydrolysis of glucoraphanin. Conversion of glucoraphanin to sulforaphane has been optimized, however, its use as functional ingredient is limited because sulforaphane is thermo-labile.
Constanza Martin, Alejandro Reyes, Andrea Mahn, Aldo Saavedra   +3 more
openaire   +2 more sources

Gas Chromatography/Mass Spectrometry Method for the Determination of Sulforaphane and Sulforaphane Nitrile in Broccoli

Journal of Agricultural and Food Chemistry, 1998
Phytochemicals, especially the secondary metabolites synthesized by plants, play key roles in human nutrition, health, wellness, and disease prevention.
William C. Chiang, Donald J. Pusateri, Richard E. A. Leitz   +2 more
openaire   +2 more sources

Comparison of the Bioactivity of Two Glucoraphanin Hydrolysis Products Found in Broccoli, Sulforaphane and Sulforaphane Nitrile

Journal of Agricultural and Food Chemistry, 2001
Epidemiological and laboratory studies suggest that dietary broccoli may prevent or delay a variety of cancers. Broccoli and other crucifers contain a relatively unique family of secondary metabolites called glucosinolates. Glucoraphanin, the major glucosinolate in broccoli, is hydrolyzed by an endogenous plant myrosinase to form either the potent ...
Elizabeth H. Jeffery, Nathan V. Matusheski   +1 more
openaire   +3 more sources

Preparative HPLC Method for the Purification of Sulforaphane and Sulforaphane Nitrile from Brassica oleracea

Journal of Agricultural and Food Chemistry, 2001
An extraction and preparative HPLC method has been devised to simultaneously purify sulforaphane and sulforaphane nitrile from the seed of Brassica oleracea var. italica cv. Brigadier. The seed was defatted with hexane, dried, and hydrolyzed in deionized water (1:9) for 8 h. The hydrolyzed seed meal was salted and extracted with methylene chloride. The
Matthew A. Wallig, John A. Juvik, Elizabeth H. Jeffery, Nathan V. Matusheski, Barbara P. Klein, Mosbah M. Kushad   +5 more
openaire   +3 more sources

THE EFFECTIVENESS OF THE ISOTHIOCYANATE SULFORAPHANE IN CHEMOPROTECTION

Acta Horticulturae, 2010
In addition to their nutritional value, edible plants are recognized as a primary and rich source of biologically active natural products. Many are capable of transcriptionally upregulating (inducing) mammalian cytoprotective enzymes. Some of the most potent naturally occurring inducers are isothiocyanates that are derived from glucosinolate precursors
openaire   +2 more sources