Results 31 to 40 of about 25,287 (258)

Chemopreventive activity of sulforaphane

Drug Design, Development and Therapy, 2018
Cancer is one of the major causes of morbidity and mortality in the world. Carcinogenesis is a multistep process induced by genetic and epigenetic changes that disrupt pathways controlling cell proliferation, apoptosis, differentiation, and senescence.
Xin Jiang, Ye Liu, Lixin Ma, Rui Ji, Yaqin Qu, Ying Xin, Guoyue Lv   +6 more
openaire   +5 more sources

Photothrombosis-induced infarction of the mouse cerebral cortex is not affected by the Nrf2-activator sulforaphane. [PDF]

PLoS ONE, 2012
Sulforaphane-induced activation of the transcription factor NF-E2 related factor 2 (Nrf2 or the gene Nfe2l2) and subsequent induction of the phase II antioxidant system has previously been shown to exert neuroprotective action in a transient model of ...
Michelle J Porritt, Helene C Andersson, Linda Hou, Åsa Nilsson, Marcela Pekna, Milos Pekny, Michael Nilsson   +6 more
doaj   +1 more source

Sulforaphane Targets TRA-1/GLI Upstream of DAF-16/FOXO to Promote C. elegans Longevity and Healthspan

Frontiers in Cell and Developmental Biology, 2021
Broccoli-derived isothiocyanate sulforaphane inhibits inflammation and cancer. Sulforaphane may support healthy aging, but the underlying detailed mechanisms are unclear. We used the C. elegans nematode model to address this question.
Huihui Ji, Zhimin Qi, Daniel Schrapel, Monika Le, Yiqiao Luo, Bin Yan, Jury Gladkich, Michael Schaefer, Li Liu, Ingrid Herr   +9 more
doaj   +1 more source

Stable sulforaphane protects against gait anomalies and modifies bone microarchitecture in the spontaneous STR/Ort model of osteoarthritis [PDF]

, 2017
Osteoarthritis (OA), affecting joints and bone, causes physical gait disability with huge socio-economic burden; treatment remains palliative. Roles for antioxidants in protecting against such chronic disorders have been examined previously. Sulforaphane
Ahmed Aljazzar, Alam, Andrea Pollard, Andrew A. Pitsillides, Behzad Javaheri, Bellido, Blandine Poulet, Boris Chan, Brewster, Carbone, Castañeda, Chambers, Chambers, Chiusaroli, Christiansen, Clarke, Conaghan, Custers, Davidson, Davidson, Doube, Duarte, Elaine Shervill, Foster, Glasson, Glasson, Goldring, Goldring, Haseeb, Hayami, Henrotin, Ho, Hochman, Isabel R. Orriss, Javaheri, Javaheri, Juge, Juhl, Karsdal, Kim, Li, Little, Lo, Mark Hopkinson, Mason, Miriam Piles, Mündermann, Pasold, Pastoureau, Pauli, Pearson, Peter D. Lee, Piles, Poulet, Poulet, Poulet, Poulet, Poulet, Pritzker, Radin, Roberto de Souza, Scheller, Schnitzer, Tat, Taylor, Thaler, Uchida, Valdes, Vincelette, Wang, Wu, Xiao, Yu-Mei Chang, Zakkar   +73 more
core   +3 more sources

Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction

Journal of the Formosan Medical Association, 2017
Background/Purpose: Cancer stem cells (CSCs) are deemed as the driving force of tumorigenesis in oral squamous cell carcinomas (OSCCs). In this study, we investigated the chemotherapeutic effect of sulforaphane, a dietary component from broccoli sprouts,
Chia-Ming Liu, Chih-Yu Peng, Yi-Wen Liao, Ming-Yi Lu, Meng-Lun Tsai, Jung-Chun Yeh, Chuan-Hang Yu, Cheng-Chia Yu   +7 more
doaj   +1 more source

The anti-arthritis effect of sulforaphane, an activator of Nrf2, is associated with inhibition of both B cell differentiation and the production of inflammatory cytokines.

PLoS ONE, 2021
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is an important transcription factor that plays a pivotal role in cellular defense against oxidative injury.
Su-Jin Moon, Jooyeon Jhun, Jaeyoon Ryu, Ji Ye Kwon, Se-Young Kim, KyoungAh Jung, Mi-La Cho, Jun-Ki Min   +7 more
doaj   +1 more source

Sulforaphanes: disruptors of phagophores and autolysosomes

Autophagy Reports, 2022
Sulforaphane and its metabolites (SFNs) cause apoptosis in cancers and could be potential anti-cancer drugs. We focused on investigating the underlying mechanisms through which SFNs inhibit cancers. First, SFNs cause microtubule disruption by phosphorylated MAPK1/ERK2-MAPK3/ERK1-mediated activation of 26S proteasome leading to a microtubule-associated ...
Yan Zhou, Wei Wu
openaire   +3 more sources

Protective Activity of Broccoli Sprout Juice in a Human Intestinal Cell Model of Gut Inflammation [PDF]

, 2016
Benefits to health from a high consumption of fruits and vegetables are well established and have been attributed to bioactive secondary metabolites present in edible plants.
Baima, Simona, Ferruzza, Simonetta, Giusti, Anna Maria, Maldini, Mariateresa, Mattivi, Fulvio, Moneta, Elisabetta, Morelli, Giorgio, Murgia, Chiara, Nardini, Mirella, Natella, Fausta, Ranaldi, Giulia, Rossi, Carlotta, Sambuy, Yula, Scaccini, Cristina, Trošt, Kajetan   +14 more
core   +3 more sources

Sulforaphane in experimental hypertension

Libyan International Medical University Journal, 2020
Abstract Background: Hypertension is defined as a failure to achieve a blood pressure (BP) target – smaller than 140/90 mmHg. The worldwide burden of hypertension has been associated with globally increased rates of death and disability. There is increasing evidence of strong relation between hypertension and oxidative stress, where either ...
Ali Banigesh, Vijitha Senanayake, Salma Bukhatwa, Bernhard Juurlink   +3 more
openaire   +2 more sources

Phytochemical Compounds and Protection from Cardiovascular Diseasesa. A State of the Art [PDF]

, 2015
Cardiovascular diseases represent a worldwide relevant socioeconomical problem. Cardiovascular disease prevention relies also on lifestyle changes, including dietary habits.
PAGLIARO, BENIAMINO ROSARIO, RUBATTU, Speranza Donatella, SANTOLAMAZZA, CATERINA, SIMONELLI, FRANCESCA   +3 more
core   +4 more sources