Results 31 to 40 of about 29,600 (252)

Sulforaphane and Its Protective Role in Prostate Cancer: A Mechanistic Approach

International Journal of Molecular Sciences, 2023
The increasing incidence of prostate cancer worldwide has spurred research into novel therapeutics for its treatment and prevention. Sulforaphane, derived from broccoli and other members of the Brassica genus, is a phytochemical shown to have anticancer ...
James Mordecai, Saleem Ullah, Irshad Ahmad   +2 more
semanticscholar   +1 more source

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder [PDF]

, 2020
Autism Spectrum Disorder (ASD) is one of the most common neurodevelopmental disorders with no drugs treating the core symptoms and no validated biomarkers for clinical use.
Connors, Susan L., Diggins, Eileen, Dinkova-Kostova, Albena, Fahey, Jed W., Liu, Hua, Singh, Kanwaljit, Stephenson, Katherine K., Zimmerman, Andrew W.   +7 more
core   +3 more sources

Protective Effect of Sulforaphane on Oxidative Stress and Mitochondrial Dysfunction Associated with Status Epilepticus in Immature Rats

Molecular Neurobiology, 2023
The present study aimed to elucidate the effect of sulforaphane (a natural isothiocyanate) on oxidative stress and mitochondrial dysfunction during and at selected periods following status epilepticus (SE) induced in immature 12-day-old rats by Li ...
J. Folbergrová, P. Ješina, J. Otáhal
semanticscholar   +1 more source

Studies on exogenous elicitors promotion of sulforaphane content in broccoli sprouts and its effect on the MDA-MB-231 breast cancer cell line

Annals of Agricultural Sciences, 2021
Broccoli (Brassica oleracea var. italica) belongs to the Brassicaceae family and is one of the most important cruciferous vegetables. It has gained popularity due to its high glucosinolate concentrations that have positive potential in cancer treatment ...
May Ahmed Amer, Thoria Rashad Mohamed, Raoufa A. Abdel Rahman, Manal Ali, Abdelfattah Badr   +4 more
doaj   +1 more source

Benefits and risks of the hormetic effects of dietary isothiocyanates on cancer prevention [PDF]

, 2014
The isothiocyanate (ITC) sulforaphane (SFN) was shown at low levels (1-5 µM) to promote cell proliferation to 120-143% of the controls in a number of human cell lines, whilst at high levels (10-40 µM) it inhibited such cell proliferation.
A Arlt, A Giudice, A Herman-Antosiewicz, A Lau, A Lister, A Melchini, A Speciale, AA Alfadda, AJ Vargas, AT Dinkova-Kostova, AV Gasper, C Cornelius, C Fimognari, C Fimognari, Changhao Sun, CR Zhao, D Li, D Rand, D Ren, Daotai Nie, DD Zhang, DS Michaud, E Warwick, EJ Calabrese, EJ Calabrese, EJ Calabrese, EJ Calabrese, ER Hahm, F Ekiz, F Galgano, F Zanichelli, GM DeNicola, GR Fenwick, GS Omenn, HK Na, I Misiewicz, I Oehme, IS Santos, J Jakubikova, J Watson, JD Clarke, JD Hayes, JD Watson, JM Cramer, K Pietsch, K Suppipat, KA Moy, KL Cheung, L Gamet-Payrastre, L Kuang, L Ye, LN Barrera, LS Cooley, M McMahon, MB Sporn, MP Mattson, MP Mattson, P Sestili, P Shelton, PE Miller, R Brigelius-Flohe, RF Clayton, RK Thimmulappa, S Homma, SA McNaughton, SJ Jackson, SL Navarro, T Hara, T Nishikawa, T Xu, TG Son, TW Kensler, TW Kensler, V Calabrese, V Rungapamestry, W Hendrickx, Wei Wang, X Ma, X Yu, XJ Wang, Y Ji, Y Li, Y Mitsuishi, Y Shan, Y Zhang, Y Zhang, Y Zhang, Y Zhang, YJ Surh, Yongping Bao, YS Keum, Zhigang Zhou   +91 more
core   +6 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Sulforaphane Combined with Vitamin D Induces Cytotoxicity Mediated by Oxidative Stress, DNA Damage, Autophagy, and JNK/MAPK Pathway Modulation in Human Prostate Tumor Cells

Nutrients, 2023
Prostate cancer ranks second in incidence worldwide. To date, there are no available therapies to effectively treat advanced and metastatic prostate cancer.
Katiuska Tuttis, A. R. T. Machado, P. Santos, L. Antunes   +3 more
semanticscholar   +1 more source

Sulforaphane alter the microbiota and mitigate colitis severity on mice ulcerative colitis induced by DSS

AMB Express, 2020
Sulforaphane (SFN) is a kind of natural isothiocyanate, which exists in cruciferous plants. Only few studies were about the anti-inflammatory effects of sulforaphane in ulcerative colitis.
Yan Zhang, Luxuan Tan, Chao Li, Han Wu, Dan Ran, Zhenyu Zhang   +5 more
doaj   +1 more source

Influence of sequential exogenous pretreatment and contact ultrasound-assisted air drying on the metabolic pathway of glucoraphanin in broccoli florets

Ultrasonics Sonochemistry, 2022
In this investigation, the combinations of exogenous pretreatment (melatonin or vitamin C) and contact ultrasound-assisted air drying were utilized to dry broccoli florets. To understand the influences of the studied dehydration methods on the conversion
Beini Liu, Yang Tao, Sivakumar Manickam, Dandan Li, Yongbin Han, Ying Yu, Dongfeng Liu   +6 more
doaj   +1 more source

Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice

Communications Biology, 2022
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), has incited a global health crisis. Currently, there are limited therapeutic options for the prevention and treatment of SARS-CoV-2 infections.
A. Ordonez, C. K. Bullen, A. Villabona-Rueda, E. Thompson, Mitchell L. Turner, V. Merino, Yu Yan, John Kim, S. Davis, Oliver Komm, J. Powell, F. D’Alessio, R. Yolken, Sanjay K. Jain, Lorraine Jones-Brando   +14 more
semanticscholar   +1 more source