Results 261 to 270 of about 33,864 (335)

Sustained Vaccine Exposure Elicits More Rapid, Consistent, and Broad Humoral Immune Responses to Multivalent Influenza Vaccines

open access: yesAdvanced Science, EarlyView.
This work presents an injectable polymer‐nanoparticle hydrogel depot platform for delivering multivalent influenza vaccines which induces stronger and more durable immune responses. The technology provides broader protection, including against heterologous and potential pandemic strains (H5N1, H7N9, H9N2), and enhances the effectiveness of commercial ...
Olivia M. Saouaf   +7 more
wiley   +1 more source

Bioprinted Patient‐Derived Organoid Arrays Capture Intrinsic and Extrinsic Tumor Features for Advanced Personalized Medicine

open access: yesAdvanced Science, EarlyView.
An embedded bioprinting enabled‐arrayed patient‐derived organoids (Eba‐PDO) platform that replicates intrinsic and extrinsic tumor characteristics is introduced. Eba‐PDOs more accurately mimic tissue than standard PDOs (Std‐PDOs) due to maturation in the tumor microenvironment.
Jonghyeuk Han   +15 more
wiley   +1 more source

Developing Quorum Sensing‐Based Collaborative Dynamic Control System in Halomonas TD01

open access: yesAdvanced Science, EarlyView.
A standardized and streamlined inducer‐free quorum sensing (QS)‐based collaborative dynamic control pattern is developed for sufficient gene expression control in Halomonas TD by mixing two engineered cells, cells A and B. Proof‐of‐concept studies are designed to test the dynamic control performance in mixed cultures in fed‐batch conditions.
Yi‐Na Lin   +12 more
wiley   +1 more source

PCSK9 Promotes the Malignancy of Triple‐negative Breast Cancer Cells by Reducing Cholesterol Levels at the Plasma Membrane to Activate EGFR and HER3

open access: yesAdvanced Science, EarlyView.
By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley   +1 more source

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