A multicenter, open-label, long-term safety and tolerability study of DFN-02, an intranasal spray of sumatriptan 10 mg plus permeation enhancer DDM, for the acute treatment of episodic migraine. [PDF]
, 2017 BackgroundDFN-02 is a novel intranasal spray formulation composed of sumatriptan 10 mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM).
Allenby, Kent +5 more
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Unilateral Facial Pain and Headache: Effects of Both Indomethacin and Sumatriptan [PDF]
Pain Research and Management, 1999 Three female patients presented with a similar pattern of unilateral facial pain and headache, reminiscent of atypical facial pain. The neck and ipsilateral shoulder (n=2) were also involved. The attacks of pain lasted from several hours to days.
Ottar Sjaastad +3 more
doaj +2 more sources
Fast Dissolving Sublingual Films Containing Sumatriptan Alone and Combined with Methoclopramide: Evaluation in Vitro Drug Release and Mucosal Permeation [PDF]
Pharmaceutical Sciences, 2016 ackground: Sumatriptan succinate is a 5-HT1 receptor agonist which is used in the treatment of migraine. It shows low bioavailability (15%) due to high hepatic first pass metabolism. The present work intended to formulate mucoadhesive sublingual films of
Maryam Maghsoodi, Mahdieh Rahmani, Hamed Ghavimi, Seyed Hassan Montazam, Saieede Soltani, Mitra Alami, Sara Salatin, Mitra Jelvehgari
doaj +2 more sources
Indian Journal of PainIntroduction: Migraine is a debilitating, neurological disorder, characterized by episodes of ipsilateral headache, often associated with symptoms such as nausea, vomiting, vertigo, and other sensory symptoms.
Anjali Kushwah, Meghna Shinde
doaj +2 more sources
Inhaled 5-HT<sub>1B</sub> <sub>/1D</sub> Receptor Antagonist Attenuates Sumatriptan-Induced Sensitization of Capsaicin-Sensitive Lung Vagal Afferents: Implications for Preventing Sumatriptan-Associated Adverse Chest Symptoms. [PDF]
Compr PhysiolOur previous study suggests that sumatriptan‐induced chest discomfort is associated with hypersensitivity of CSLV afferents via 5‐HT1B/1D receptors on nerve endings. The present study demonstrates that inhaled 5‐HT1B/1D receptor antagonism suppresses this hypersensitivity without compromising antimigraine efficacy, supporting local pulmonary antagonism
Chan NJ, Yuan ZF, Kuo CC, Hsu CC.
europepmc +2 more sources
Integrating gepants into clinical practice for the acute treatment of migraine. [PDF]
HeadacheAbstract Objective To assess the role of small‐molecule calcitonin gene–related peptide receptor antagonists (gepants) in the acute treatment of migraine, particularly in relation to triptan treatments. Background Triptans have established efficacy and are widely prescribed for the acute treatment of migraine.
Lipton RB +4 more
europepmc +2 more sources
Copper Oxide Based Disposable Sensors for Sensitive Voltammetric Assay of Sumatriptan
International Journal of Electrochemical Science, 2021 Sumatriptan (SUM) is a member of the triptan family that is widely applied for the treatment of cluster headache attacks and migraines. Herein, novel disposable screen-printed sensors (SPS) were incorporated in situ with copper oxide nanoparticles (CuO ...
Afrah M. Aldawsari +6 more
doaj +1 more source
Chitosan coating of anionic liposomes containing sumatriptan succinate: a candidate for nasal administration [PDF]
Nanomedicine Journal, 2021 Objective(s): Sumatriptan is a routine medication in the treatment of migraine and cluster headache that is generally given by oral or parental routes. However, a substantial proportion of patients suffer severe side effects.
Sara Assadpour +2 more
doaj +1 more source
Investigation of sumatriptan and ketorolac trometamol in the human experimental model of headache
The Journal of Headache and Pain, 2020 Background Pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) induces headache in healthy volunteers but the precise mechanisms by which PACAP38 leads to headache are unclear. We investigated the headache preventive effect of sumatriptan and
Hashmat Ghanizada +7 more
doaj +1 more source
Biosensors, 2022 In this work, Ni-Co layered double hydroxide (Ni–Co LDH) hollow nanostructures were synthesized and characterized by X-ray diffraction (XRD), field emission-scanning electron microscopy (FE-SEM), and Fourier-transform infrared spectroscopy (FT-IR ...
Hadi Beitollahi +4 more
doaj +1 more source