Results 11 to 20 of about 300,823 (367)
Site-specific identification and quantitation of endogenous SUMO modifications under native conditions [PDF]
Nature Communications, 2017 Small ubiquitin-like modifier (SUMO) modification regulates numerous cellular processes. Unlike ubiquitin, detection of endogenous SUMOylated proteins is limited by the lack of naturally occurring protease sites in the C-terminal tail of SUMO proteins ...
R. Lumpkin +8 more
semanticscholar +4 more sources
Identification of proximal SUMO-dependent interactors using SUMO-ID [PDF]
Nature Communications, 2020 Abstract The fast dynamics and reversibility of posttranslational modifications by the ubiquitin family pose significant challenges for research. Here we present SUMO-ID, a technology that merges proximity biotinylation by TurboID and protein-fragment complementation to find SUMO-dependent interactors of proteins of interest.
Orhi Barroso-Gomila +15 more
openaire +7 more sources
SUMO chain formation is required for response to replication arrest in S. pombe. [PDF]
PLoS ONE, 2009 SUMO is a ubiquitin-like protein that is post-translationally attached to one or more lysine residues on target proteins. Despite having only 18% sequence identity with ubiquitin, SUMO contains the conserved betabetaalphabetabetaalphabeta fold present in
Andrew Skilton +4 more
doaj +12 more sources
Dealing With Stress: A Review of Plant SUMO Proteases
Frontiers in Plant Science, 2019 The SUMO system is a rapid dynamic post-translational mechanism employed by eukaryotic cells to respond to stress. Plant cells experience hyperSUMOylation of substrates in response to stresses such as heat, ethanol, and drought.
Rebecca Morrell, Ari Sadanandom
doaj +2 more sources
SUMO enables substrate selectivity by mitogen-activated protein kinases to regulate immunity in plants [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance The functional diversity of MAPKs is dependent on differential selection of substrates for phosphorylation. Nevertheless, the mechanisms assisting MAPKs to maintain substrate specificity in plants are not known.
Vivek Verma +10 more
openalex +2 more sources
Journal of Medicinal Chemistry, 2021 SUMOylation is a reversible post-translational modification that regulates protein function through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of SUMOylating proteins involves an enzymatic cascade, the first step of
S. Langston +52 more
semanticscholar +1 more source
SUMO Interacting Motifs: Structure and Function
Cells, 2021 Small ubiquitin-related modifier (SUMO) is a member of the ubiquitin-related protein family. SUMO modulates protein function through covalent conjugation to lysine residues in a large number of proteins.
T. Yau +3 more
semanticscholar +1 more source
EMBO Journal, 2021 DNA‐protein crosslinks (DPCs) obstruct essential DNA transactions, posing a serious threat to genome stability and functionality. DPCs are proteolytically processed in a ubiquitin‐ and DNA replication‐dependent manner by SPRTN and the proteasome but can ...
Julio C Y Liu +15 more
semanticscholar +1 more source
Therapeutic Potential of Targeting the SUMO Pathway in Cancer
Cancers, 2021 Simple Summary The small ubiquitin-like modifier (SUMO) pathway regulates the hallmark properties of cancer cells. Moreover, alterations in activity and in levels of SUMO machinery components have been observed in human cancer.
Antti Kukkula +5 more
semanticscholar +1 more source