Results 11 to 20 of about 280,184 (238)

SUMO Interacting Motifs: Structure and Function

open access: yesCells, 2021
Small ubiquitin-related modifier (SUMO) is a member of the ubiquitin-related protein family. SUMO modulates protein function through covalent conjugation to lysine residues in a large number of proteins.
T. Yau   +3 more
semanticscholar   +1 more source

Therapeutic Potential of Targeting the SUMO Pathway in Cancer

open access: yesCancers, 2021
Simple Summary The small ubiquitin-like modifier (SUMO) pathway regulates the hallmark properties of cancer cells. Moreover, alterations in activity and in levels of SUMO machinery components have been observed in human cancer.
Antti Kukkula   +5 more
semanticscholar   +1 more source

SUMO is a pervasive regulator of meiosis

open access: yeseLife, 2021
Protein modification by SUMO helps orchestrate the elaborate events of meiosis to faithfully produce haploid gametes. To date, only a handful of meiotic SUMO targets have been identified.
Nikhil R Bhagwat   +12 more
semanticscholar   +1 more source

Mechanism and function of DNA replication‐independent DNA‐protein crosslink repair via the SUMO‐RNF4 pathway

open access: yesEMBO Journal, 2021
DNA‐protein crosslinks (DPCs) obstruct essential DNA transactions, posing a serious threat to genome stability and functionality. DPCs are proteolytically processed in a ubiquitin‐ and DNA replication‐dependent manner by SPRTN and the proteasome but can ...
Julio C Y Liu   +15 more
semanticscholar   +1 more source

Automating process design by coupling genetic algorithms with commercial simulators: a case study for hybrid MABR processes

open access: yesWater Science and Technology, 2022
The development of commercial software and simulators has progressed to assist engineers to optimize design, operation, and control of wastewater treatment processes.
Cheng Yang   +2 more
doaj   +1 more source

SUMO and Transcriptional Regulation: The Lessons of Large-Scale Proteomic, Modifomic and Genomic Studies

open access: yesMolecules, 2021
One major role of the eukaryotic peptidic post-translational modifier SUMO in the cell is transcriptional control. This occurs via modification of virtually all classes of transcriptional actors, which include transcription factors, transcriptional ...
Mathias Boulanger   +4 more
semanticscholar   +1 more source

Promyelocytic leukemia nuclear body-like structures can assemble in mouse oocytes

open access: yesBiology Open, 2022
Promyelocytic leukemia (PML) nuclear bodies (PML-NBs), a class of membrane-less cellular organelles, participate in various biological activities. PML-NBs are known as the core-shell-type nuclear body, harboring ‘client’ proteins in their core.
Osamu Udagawa   +2 more
doaj   +1 more source

Traffic Simulation with Open-Source and Commercial Traffic Microsimulators: A Case Study

open access: yesCommunications, 2022
The analysis of traffic problems in large urban centers often requires the use of computational tools, which give the possibility to make a more detailed analysis of the issue, suggest solutions, predict behaviors and, above all, support efficient ...
Nelson Baza-Solares   +4 more
doaj   +1 more source

SUMO: From Bench to Bedside.

open access: yesPhysiological Reviews, 2020
Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates multiple biological processes, including cell division, DNA replication/repair, signal transduction, and cellular metabolism.
Hui-Ming Chang, E. Yeh
semanticscholar   +1 more source

SUMO enables substrate selectivity by mitogen-activated protein kinases to regulate immunity in plants

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2021
Significance The functional diversity of MAPKs is dependent on differential selection of substrates for phosphorylation. Nevertheless, the mechanisms assisting MAPKs to maintain substrate specificity in plants are not known.
Vivek Verma   +10 more
semanticscholar   +1 more source

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