Results 11 to 20 of about 280,184 (238)
SUMO Interacting Motifs: Structure and Function
Cells, 2021 Small ubiquitin-related modifier (SUMO) is a member of the ubiquitin-related protein family. SUMO modulates protein function through covalent conjugation to lysine residues in a large number of proteins.
T. Yau +3 more
semanticscholar +1 more source
Therapeutic Potential of Targeting the SUMO Pathway in Cancer
Cancers, 2021 Simple Summary The small ubiquitin-like modifier (SUMO) pathway regulates the hallmark properties of cancer cells. Moreover, alterations in activity and in levels of SUMO machinery components have been observed in human cancer.
Antti Kukkula +5 more
semanticscholar +1 more source
SUMO is a pervasive regulator of meiosis
eLife, 2021 Protein modification by SUMO helps orchestrate the elaborate events of meiosis to faithfully produce haploid gametes. To date, only a handful of meiotic SUMO targets have been identified.
Nikhil R Bhagwat +12 more
semanticscholar +1 more source
EMBO Journal, 2021 DNA‐protein crosslinks (DPCs) obstruct essential DNA transactions, posing a serious threat to genome stability and functionality. DPCs are proteolytically processed in a ubiquitin‐ and DNA replication‐dependent manner by SPRTN and the proteasome but can ...
Julio C Y Liu +15 more
semanticscholar +1 more source
Water Science and Technology, 2022 The development of commercial software and simulators has progressed to assist engineers to optimize design, operation, and control of wastewater treatment processes.
Cheng Yang +2 more
doaj +1 more source
Molecules, 2021 One major role of the eukaryotic peptidic post-translational modifier SUMO in the cell is transcriptional control. This occurs via modification of virtually all classes of transcriptional actors, which include transcription factors, transcriptional ...
Mathias Boulanger +4 more
semanticscholar +1 more source
Promyelocytic leukemia nuclear body-like structures can assemble in mouse oocytes
Biology Open, 2022 Promyelocytic leukemia (PML) nuclear bodies (PML-NBs), a class of membrane-less cellular organelles, participate in various biological activities. PML-NBs are known as the core-shell-type nuclear body, harboring ‘client’ proteins in their core.
Osamu Udagawa +2 more
doaj +1 more source
Traffic Simulation with Open-Source and Commercial Traffic Microsimulators: A Case Study
Communications, 2022 The analysis of traffic problems in large urban centers often requires the use of computational tools, which give the possibility to make a more detailed analysis of the issue, suggest solutions, predict behaviors and, above all, support efficient ...
Nelson Baza-Solares +4 more
doaj +1 more source
Physiological Reviews, 2020 Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates multiple biological processes, including cell division, DNA replication/repair, signal transduction, and cellular metabolism.
Hui-Ming Chang, E. Yeh
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance The functional diversity of MAPKs is dependent on differential selection of substrates for phosphorylation. Nevertheless, the mechanisms assisting MAPKs to maintain substrate specificity in plants are not known.
Vivek Verma +10 more
semanticscholar +1 more source