Results 91 to 100 of about 32,358 (200)

GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression [PDF]

, 2015
Guoqiang Hua, Laetitia Paulen, Pierre Chambon   +2 more
openalex   +1 more source

Constitutive nitric oxide synthases deficiency impairs cyclobutane pyrimidine dimer repair following solar UV exposure in cells and mice

Photochemistry and Photobiology, EarlyView.
Proposed model for the dual role of cNOS in DNA damage and repair upon UV radiation. Abstract Solar ultraviolet (sUV) radiation is a major environmental factor that induces DNA damage, promoting skin aging and carcinogenesis. The formation of cyclobutane pyrimidine dimers (CPDs) is one of the most prevalent forms of UV‐induced DNA lesions, playing a ...
Veronica Bahamondes Lorca, Yuxi Zhou, Christina Athans, Hailey Payne, Madison Wright, Zeinab Feyyaz, Lingying Tong, Dawn L. Sammons, Shiyong Wu   +8 more
wiley   +1 more source

SUMOylation Promotes Nuclear Import and Stabilization of Polo-like Kinase 1 to Support Its Mitotic Function [PDF]

, 2017
Donghua Wen, Jian Wu, Lei Wang, Zheng Fu
openalex   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Multifaceted roles of SUMO in DNA metabolism

Nucleus
Sumoylation, a process in which SUMO (small ubiquitin like modifier) is conjugated to target proteins, emerges as a post-translational modification that mediates protein−protein interactions, protein complex assembly, and localization of target proteins.
Yee Mon Thu
doaj   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
The vitamin D receptor (VDR) regulates hair follicle biology through ligand‐dependent and ligand‐independent mechanisms by heterodimerizing with retinoid X receptor, recruiting coactivator complexes, and activating target genes including Wnt inhibitors, hair keratins, and cell cycle regulators.
Liancheng Guan, Fan Yang, Meijuan Li, Yujia Chen, Zexin Zhao, Hongxia Li, Deping Luo, Qian Li, Yunzhi Chen   +8 more
wiley   +1 more source

Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis [PDF]

, 2019
Pei-Fang Hung, Tse‐Ming Hong, Che‐Chang Chang, Chung‐Lieh Hung, Yuan-Ling Hsu, Yih‐Leong Chang, Chen‐Tu Wu, Gee‐Chen Chang, Nei‐Li Chan, Sung‐Liang Yu, Pan‐Chyr Yang, Szu‐Hua Pan   +11 more
openalex   +1 more source

Research Progress of Exosome‐Derived microRNA in Alcohol Use Disorders: A Critical Review

Addiction Biology, Volume 31, Issue 2, February 2026.
Exosome‐derived microRNAs represent stable and mechanistically active mediators of alcohol‐induced multi‐organ injury. This review summarizes how chronic alcohol exposure reshapes exosomal miRNA cargo across the liver, immune system, and brain, highlighting key miRNAs with diagnostic value and therapeutic potential.
Bo Zhang, Ting ting Xie, Qiang Ma, Ya ping Jiang, Yu mei Wang   +4 more
wiley   +1 more source