Results 91 to 100 of about 31,613 (261)

Proteomics Insights Into Lysosome Biogenesis and Maturation

PROTEOMICS, EarlyView.
ABSTRACT Lysosomes constitute the main degradative organelle of most eukaryotic cells and are capable of breaking down a wide spectrum of biomolecules, including proteins, lipids, glycans, and DNA/RNA. They play crucial roles in the regulation of cellular homeostasis, acting as metabolic signaling centers for the correlation of nutrient availability ...
Katharina Hirn, Sofía Fajardo‐Callejón, Dominic Winter   +2 more
wiley   +1 more source

Optimizing (Bio) Catalysis with Liquid‐Liquid Phase Separation Systems

ChemSystemsChem, EarlyView.
This review highlights how LLPS creates membraneless compartments involved in different scenarios in nature. It further explores different examples that focus on the development of synthetic coacervates that enhance catalytic efficiency by concentrating reactants, or by the direct influence of the coacervates building blocks themselves.
David Q. P. Reis, Joana Calvário, Inês Chibeles, Mohit Kumar, Ana S. Pina   +4 more
wiley   +1 more source

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

SUMOylation effects on neural stem cells self-renewal, differentiation, and survival

Neuroscience Research
SUMO (small ubiquitin-like modifier) conjugation or SUMOylation, a post-translational modification, is a crucial regulator of protein function and cellular processes.
Letícia Yoshitome Queiroz, Ryoichiro Kageyama, Helena I. Cimarosti   +2 more
doaj   +1 more source

STN1 Shields CTC1 From TRIM32‐Mediated Ubiquitination to Prevent Cellular Aging

Aging Cell, EarlyView.
STN1 safeguards CTC1 from TRIM32‐mediated ubiquitin‐proteasome degradation, thereby preserving CST complex integrity and its roles in telomere maintenance, DNA replication, and DNA damage repair. ABSTRACT The CST (CTC1‐STN1‐TEN1) complex, a single‐stranded DNA (ssDNA) binding complex, is essential for telomere maintenance and genome stability ...
Yina Lan, Xiaole Liang, Guotao Kuang, Tengfei Ma, Fangyingnan Zhang, Zaoli Huang, Huan Wang, Zhenhua Luo, Xuyang Feng   +8 more
wiley   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

ZNF282 Promotes Colorectal Cancer Progression Possibly via E2F1 Activation

Cancer Science, EarlyView.
ZNF282 is a zinc finger protein overexpressed in colorectal cancer that facilitates tumor progression by promoting cell cycle progression via E2F1 activation. Our study demonstrates that ZNF282 expression is associated with poor prognosis and may serve as a novel prognostic biomarker and therapeutic target. ABSTRACT Colorectal cancer (CRC) is a leading
Tadashi Abe, Takaaki Masuda, Taro Tobo, Masahiro Hashimoto, Yusuke Nakano, Hideyuki Saito, Takashi Ofuchi, Tomohiko Ikehara, Akinori Tsujimoto, Takafumi Nakano, Katsushi Dairaku, Junichi Takahashi, Kensuke Koike, Koto Kawata, Yuki Ando, Kiyotaka Hosoda, Takanari Tatsumi, Kosuke Hirose, Satoshi Higuchi, Hajime Otsu, Yusuke Yonemura, Ken Eto, Toru Ikegami, Koshi Mimori   +23 more
wiley   +1 more source

Involvement of PIAS1 in the Sumoylation of Tumor Suppressor p53 [PDF]

, 2001
Tomoaki Kahyo, Tamotsu Nishida, Hideyo Yasuda   +2 more
openalex   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, EarlyView.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

Deciphering SCN2A: A comprehensive review of rodent models of Scn2a dysfunction

Epilepsia, EarlyView.
Abstract SCN2A encodes for the alpha subunit of the voltage‐gated sodium channel NaV1.2, which is involved in action potential initiation and backpropagation in excitatory neurons. Currently, it is one of the highest monogenetic risk factors for both epilepsy and autism spectrum disorder.
Katelin E. J. Scott, Maria Fernanda Hermosillo Arrieta, Aislinn J. Williams   +2 more
wiley   +1 more source