ZNF282 Promotes Colorectal Cancer Progression Possibly via E2F1 Activation
Cancer Science, Volume 117, Issue 1, Page 90-104, January 2026.ZNF282 is a zinc finger protein overexpressed in colorectal cancer that facilitates tumor progression by promoting cell cycle progression via E2F1 activation. Our study demonstrates that ZNF282 expression is associated with poor prognosis and may serve as a novel prognostic biomarker and therapeutic target. ABSTRACT Colorectal cancer (CRC) is a leading
Tadashi Abe +23 more
wiley +1 more source
TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models
The FEBS Journal, Volume 293, Issue 2, Page 348-384, January 2026.The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir +7 more
wiley +1 more source
Processing of DNA Topoisomerase II–DNA–Protein Crosslinks Associated With Anticancer Drugs
Genes to Cells, Volume 31, Issue 1, January 2026.Topoisomerase II (TOP2) relieving DNA torsional stress is trapped by TOP2 poisons, such as etoposide, inducing DNA double‐strand breaks (DSBs) bearing TOP2–DNA–protein crosslinks (TOP2–DPCs), which must be removed before DSB repair. This review summarizes the TOP2–DPC resolution processes mediated by multiple pathways, including proteolysis and ...
Ryo Sakasai, Kuniyoshi Iwabuchi
wiley +1 more source
AIRE's Complex Role Beyond Promiscuous Gene Expression
Immunological Reviews, Volume 337, Issue 1, January 2026.ABSTRACT Central tolerance, established in the thymus, ensures T cells are nonreactive to self‐antigens while maintaining a functional immune repertoire. Medullary thymic epithelial cells (mTECs) and thymic dendritic cells (DCs) play a crucial role in this mechanism by orchestrating the selection and deletion of autoreactive thymocytes, a process ...
Pärt Peterson
wiley +1 more source
Sex differences in the physiological response to acute anterior cruciate ligament overuse
The Journal of Physiology, Volume 604, Issue 1, Page 297-316, 1 January 2026.Abstract figure legend With equivalent in vivo fatigue loading of the anterior cruciate ligament (ACL), females accumulate more tissue damage and mount a slower reparative response than males, when the applied loads between sexes are equivalent. By contrast, males accumulate less tissue damage and mount a robust reparative response that includes ...
Stephen H. Schlecht +5 more
wiley +1 more source
Sumoylation of transcription factor MYB30 by the small ubiquitin-like modifier E3 ligase SIZ1 mediates abscisic acid response in Arabidopsis thaliana [PDF]
, 2012 Yuan Zheng, Karen S. Schumaker, Yan Guo
openalex +1 more source
EFSA Journal, Volume 24, Issue 1, January 2026.Abstract The qualified presumption of safety (QPS) process was developed to provide a harmonised safety assessment approach to support EFSA Scientific Panels and Units. The QPS approach assesses the taxonomic identity, body of relevant knowledge and safety of microorganisms intentionally added to the food and feed chain.
EFSA Panel on Biological Hazards (BIOHAZ) +28 more
wiley +1 more source
SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitive impairments [PDF]
, 2019 Min Qin +10 more
openalex +1 more source
New Insights into TFEB SUMOylation and Its Role in Lipid Metabolism and Cardiovascular Disease. [PDF]
Int J Mol SciMeng Q +6 more
europepmc +1 more source