Results 121 to 130 of about 37,758 (275)

Clinical and plasma proteomic characterization of heart failure with supranormal left ventricular ejection fraction: An emerging entity of heart failure

European Journal of Heart Failure, EarlyView.
Heart failure (HF) with supranormal ejection fraction (HFsnEF) is an unnoticed but emerging entity in HF. This study showed that HFsnEF carries a similarly increased cardiovascular risk as HF with reduced ejection fraction (HFrEF) and distinct structural and proteomic characteristics from HFrEF, warranting a further comprehensive understanding and ...
Yasuhiko Sakata, Kotaro Nochioka, Satoshi Yasuda, Koichi Ishida, Takashi Shiroto, Jun Takahashi, Shintaro Kasahara, Ruri Abe, Shinsuke Yamanaka, Takahide Fujihashi, Hideka Hayashi, Shintaro Kato, Katsunori Horii, Kanako Teramoto, Tsutomu Tomita, Satoshi Miyata, Koichiro Sugimura, Iwao Waga, Masao Nagasaki, Hiroaki Shimokawa   +19 more
wiley   +1 more source

SUMOylation is essential for Sirt2 tumor-suppressor function in neuroblastoma

Neoplasia: An International Journal for Oncology Research, 2021
SUMOylation is an important post-translational modification that participates in a variety of cellular physiological and pathological processes in eukaryotic cells. Sirt2, a NAD+-dependent deacetylase, usually exerts a tumor-suppressor function. However,
Wenmei Lu, Qian Wang, Ci Xu, Haihua Yuan, Qiang Fan, Biying Chen, Renjie Cai, Danhong Wu, Ming Xu   +8 more
doaj  

SUMOylation in Human Pathogenic Fungi: Role in Physiology and Virulence

Journal of Fungi, 2020
The small ubiquitin-related modifier (SUMO) protein is an important component of the post-translational protein modification systems in eukaryotic cells.
Mahima Sagar Sahu, Sandip Patra, Kundan Kumar, Rupinder Kaur   +3 more
doaj   +1 more source

Histone sumoylation promotes Set3 histone-deacetylase complex-mediated transcriptional regulation

Nucleic Acids Research, 2020
Histones are substrates of the SUMO (small ubiquitin-like modifier) conjugation pathway. Several reports suggest histone sumoylation affects transcription negatively, but paradoxically, our genome-wide analysis shows the modification concentrated at many
Hong-Yeoul Ryu, Dejian Zhao, Jianhui Li, D. Su, M. Hochstrasser   +4 more
semanticscholar   +1 more source

Protein Post‐Translational Modification‐Mediated Control of Type I Interferon Cascade Signaling

Medicine Bulletin, EarlyView.
ABSTRACT Type I interferons (IFN‐Is) constitute the primary defense mechanism against pathogenic infections in the human body. The antiviral signaling mediated by IFN‐I is integral to the host immune response. Nevertheless, an imbalance in IFN‐I function can perturb the organism’s homeostasis. Consequently, it is imperative for the body to meticulously
Xiangjie Chen, Qiao Cheng, Fang Gong, Hui Zheng   +3 more
wiley   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Tollip Is a Mediator of Protein Sumoylation

PLoS ONE, 2009
Tollip is an interactor of the interleukin-1 receptor involved in its activation. The endosomal turnover of ubiquitylated IL-1RI is also controlled by Tollip. Furthermore, together with Tom1, Tollip has a general role in endosomal protein traffic. This work shows that Tollip is involved in the sumoylation process.
Ciarrocchi A., D'Angelo R., Cordiglieri C., Rispoli A., Santi S., Riccio M., Carone S., MANCIA, Annalaura, Paci S., Cipollini E., Ambrosetti D, Melli M.   +11 more
openaire   +7 more sources

Comparative Analysis of the Progesterone Receptor Interactome in the Human Ovarian Granulosa Cell Line KGN and Other Female Reproductive Cells

PROTEOMICS, EarlyView.
ABSTRACT The nuclear steroid hormone receptor progesterone receptor (PGR) is expressed in granulosa cells in the ovarian follicle in a tightly regulated pattern in response to the surge of luteinizing hormone (LH) that stimulates ovulation. PGR plays a critical role in mediating ovulation in response to LH, however, the mechanism for this is still ...
Natalie J. Foot, Doan T. Dinh, Samantha J. Emery‐Corbin, Jumana M. Yousef, Laura F. Dagley, Darryl L. Russell   +5 more
wiley   +1 more source

Protein Sumoylation with SUMO1 Promoted by Pin1 in Glioma Stem Cells Augments Glioblastoma Malignancy.

Neuro-Oncology, 2020
BACKGROUND The tumorigenic potential of glioma stem cells (GSCs) is associated with multiple reversible molecular alternations, but the role of post-translational protein sumoylation in GSCs has not been elucidated. The development of GSC-targeting drugs
Aili Zhang, Weiwei Tao, Kui Zhai, X. Fang, Zhi Huang, Jennifer S. Yu, Andrew E Solan, J. Rich, Wenchao Zhou, S. Bao   +9 more
semanticscholar   +1 more source

SUMOylation-Mediated Response to Mitochondrial Stress

International Journal of Molecular Sciences, 2020
Mitochondrial stress is considered as a factor that reprograms the mitochondrial biogenesis and metabolism. As known, SUMOylation occurs through a series of stress-induced biochemical reactions. During the process of SUMOylation, the small ubiquitin-like
Jianli He, Jinke Cheng, Tianshi Wang
semanticscholar   +1 more source