Results 131 to 140 of about 31,613 (261)

Positive and negative regulation of APP amyloidogenesis by sumoylation

open access: green, 2002
Yonghong Li   +5 more
openalex   +1 more source

Conformational Rearrangement of Fission DSPs

open access: yesBioEssays, Volume 47, Issue 11, November 2025.
Assembly properties of fission DSPs. Fission DSPs exist in a dynamic equilibrium of oligomer states in the cytosol, where they must be activated by partner proteins or lipid to induce assembly, and upon GTP hydrolysis, constriction. ABSTRACT Dynamin superfamily proteins (DSPs) are large GTPases that play crucial roles in membrane remodeling processes ...
Anelise N. Hutson   +2 more
wiley   +1 more source

Akebia Saponin D Targeting Ubiquitin Carboxyl‐Terminal Hydrolase 4 Promotes Peroxisome Proliferator‐Activated Receptor Gamma Deubiquitination and Activation of Brown Adipose Tissue Thermogenesis in Obesity

open access: yesMedComm, Volume 6, Issue 11, November 2025.
ASD, a natural plant product screened from small molecule compound library, is an antiobesity agent in mice. ASD promotes BAT thermogenesis to inhibit body weight gain. USP4 was identified and validated as a direct molecular target of ASD. ASD‐induced thermogenesis is modulated by a USP4–PPARγ–UCP1 axis.
Lang Chen   +13 more
wiley   +1 more source

Collaboration between two conserved sequence motifs drives ATPase stimulation of Hsp90 by Aha1

open access: yesProtein Science, Volume 34, Issue 11, November 2025.
Abstract Hsp90 is a dimeric molecular chaperone essential for the folding, stabilization, activation, and maturation of hundreds of client proteins, which are critical for cellular function. Co‐chaperones, such as Aha1, play a key role in regulating the ATP‐dependent Hsp90 client activation cycle by modulating Hsp90's ATPase activity and controlling ...
Desmond Prah Amoah   +4 more
wiley   +1 more source

Pias1 Interaction and Sumoylation of Metabotropic Glutamate Receptor 8 [PDF]

open access: hybrid, 2005
Zhongshu Tang   +3 more
openalex   +1 more source

The role of post‐translational modifications in the dynamics of cytoplasmic biomolecular condensates in plants

open access: yesNew Phytologist, Volume 248, Issue 4, Page 1692-1699, November 2025.
Summary Cytoplasmic biomolecular condensates are membrane‐less structures important for cell homeostasis, especially during stress conditions. These aggregates concentrate RNA, protein, and metabolites during a wide variety of stresses. The formation of cytoplasmic biomolecular condensates was studied extensively in plants, revealing many key actors ...
Margaux Legoux   +2 more
wiley   +1 more source

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