Results 141 to 150 of about 37,758 (275)

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Viruses and sumoylation: recent highlights

Current Opinion in Microbiology, 2006
Since its discovery in 1997, SUMO (small ubiquitin-like modifier) has been implicated in a range of activities, indicating that this protein is as important in the cell as ubiquitin is. Although it can function throughout the cell, it appears to be involved more in nuclear functions.
Susanna Chiocca, Roberto Boggio
openaire   +3 more sources

Opposed Regulation of Corepressor CtBP by SUMOylation and PDZ Binding [PDF]

, 2003
Xia Lin, Baohua Sun, Min Liang, Yao-Yun Liang, Andreas Gast, Jeffrey D. Hildebrand, F. Charles Brunicardi, Frauke Melchior, Xin‐Hua Feng   +8 more
openalex   +1 more source

ESSENTIAL MEIOTIC ENDONUCLEASE 1 is required for chloroplast development and DNA repair in rice

Plant Biotechnology Journal, EarlyView.
Summary Chloroplast development is fundamental to photosynthesis and plant growth but is sensitive to environmental stress. Chloroplast development and division require genome stability and DNA repair, but the underlying mechanisms have been unclear. Using a forward genetic approach, we identified the striped‐leaf mutant k48 in the rice (Oryza sativa L.
Yanxin Du, Yang Li, Weijiang Tang, Weiping Mo, Tingting Ma, Rongcheng Lin   +5 more
wiley   +1 more source

A Unique SUMO-Interacting Motif of Trx2 Is Critical for Its Mitochondrial Presequence Processing and Anti-oxidant Activity

Frontiers in Physiology, 2019
ObjectiveMitochondrial thioredoxin 2 (Trx2) is a vital mitochondrial redox protein that mediates normal protein thiol reduction and provides electrons to peroxiredoxin 3 (Prx3) to scavenge H2O2 in mitochondria.
Chaofei Chen, Chaofei Chen, Kang Wang, Kang Wang, Haifeng Zhang, Huanjiao Jenny Zhou, Yuxin Chen, Wang Min   +7 more
doaj   +1 more source

Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology

CA: A Cancer Journal for Clinicians, EarlyView.
Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari, Johnson Ung, Jeffrey W. Craig, Kallesh D. Jayappa, Ipsita Pal, David J. Feith, Thomas P. Loughran Jr, Owen A. O’Connor   +7 more
wiley   +1 more source

Multifaceted roles of SUMO in DNA metabolism

Nucleus
Sumoylation, a process in which SUMO (small ubiquitin like modifier) is conjugated to target proteins, emerges as a post-translational modification that mediates protein−protein interactions, protein complex assembly, and localization of target proteins.
Yee Mon Thu
doaj   +1 more source

Proteins of the PIAS family enhance the sumoylation of the papillomavirus E1 protein [PDF]

, 2004
Germán Rosas-Acosta, Martijn A. Langereis, Adeline F. Deyrieux, Van G. Wilson   +3 more
openalex   +1 more source

The Pepper E3 Ligase CaGIR1 Acts as a Negative Regulator of Drought Response via Controlling CaGRAS1 Stability

Plant, Cell &Environment, Volume 48, Issue 7, Page 5498-5513, July 2025.
ABSTRACT The ubiquitin‐proteasome pathway modulates protein stability, which impacts plant responses to abiotic stresses, such as drought. Our previous study reported that the pepper GRAS‐type transcription factor CaGRAS1 plays a positive role in drought resistance.
Woonhee Baek, Donghyuk Oh, Lim Chae Woo, Sung Chul Lee   +3 more
wiley   +1 more source

Sumoylation fights “aggregopathies” [PDF]

Cell Cycle, 2012
Jochen H. Weishaupt, Petranka Krumova
openaire   +2 more sources