Results 71 to 80 of about 53,155 (238)

Protein SUMOylation and Its Research Progress in Maize

Guangdong nongye kexue, 2023
Small ubiquitin-like modification (SUMOylation) is a crucial post-translational modification of proteins that plays a vital role in various biological processes in plants.
Ruiqiang LAI, Ming CHEN, Xiaoming XUE, Yuanqiang HU, Lina FAN, Yongwen QI   +5 more
doaj   +1 more source

SUMOylation in Drosophila Development [PDF]

Biomolecules, 2012
Small ubiquitin-related modifier (SUMO), an ~90 amino acid ubiquitin-like protein, is highly conserved throughout the eukaryotic domain. Like ubiquitin, SUMO is covalently attached to lysine side chains in a large number of target proteins. In contrast to ubiquitin, SUMO does not have a direct role in targeting proteins for proteasomal degradation ...
Smith, Matthew, Turki-Judeh, Wiam, Courey, Albert J   +2 more
openaire   +5 more sources

Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels. [PDF]

, 2020
Acute cardiac hypoxia produces life-threatening elevations in late sodium current (ILATE) in the human heart. Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of NaV1.5 channels so they reopen when normally inactive, late in the ...
Dai, Hui, Goldstein, Steve AN, Plant, Leigh D, Romero, Jesus, Xiong, Dazhi   +4 more
core  

The Ecm11-Gmc2 complex promotes synaptonemal complex formation through assembly of transverse filaments in budding yeast [PDF]

, 2013
During meiosis, homologous chromosomes pair at close proximity to form the synaptonemal complex (SC). This association is mediated by transverse filament proteins that hold the axes of homologous chromosomes together along their entire length. Transverse
AB Zavec, AB Zavec, AJ Macqueen, AV Smith, B Kemp, B Rockmill, B Rockmill, Bilge Argunhan, BL Schneider, CE de Carvalho, CH Cheng, CM Lake, CS Eichinger, DK Bishop, E Alani, E Bolcun-Filas, F Storici, FM Lin, G Hamer, GA Brar, GV Börner, GW Hooker, H Tsubouchi, H Tsubouchi, H Tsubouchi, Hideo Tsubouchi, J Perry, JE Falk, JL Gerton, JR Hudson, L Newnham, M Lussier, M Petronczki, M Primig, M Shinohara, M Sym, M Sym, Martina Dvorackova, MN Gladstone, MS Longtine, N Hunter, Neil Humphryes, P James, PR Chua, R. Scott Hawley, S Agarwal, S Chu, S Farmer, S Schramm, SL Page, SY Chen, T Tsubouchi, T Tsubouchi, T Tsubouchi, Wing-Kit Leung, Y Costa, Yaroslav Terentyev   +56 more
core   +3 more sources

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

SUMOylating Two Distinct Sites on the A-type Potassium Channel, Kv4.2, Increases Surface Expression and Decreases Current Amplitude

Frontiers in Molecular Neuroscience, 2019
Post-translational conjugation of Small Ubiquitin-like Modifier (SUMO) peptides to lysine (K) residues on target proteins alters their interactions. SUMOylation of a target protein can either promote its interaction with other proteins that possess SUMO ...
Meghyn A. Welch, Lori A. Forster, Selin I. Atlas, Deborah J. Baro, Deborah J. Baro   +4 more
doaj   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylation. [PDF]

PLoS ONE, 2008
Human cystathionine beta-synthase (CBS) catalyzes the first irreversible step in the transsulfuration pathway and commits homocysteine to the synthesis of cysteine. Mutations in CBS are the most common cause of severe hereditary hyperhomocysteinemia.
Nitish Agrawal, Ruma Banerjee
doaj   +1 more source

Histone sumoylation and chromatin dynamics

Nucleic Acids Research, 2021
Abstract Chromatin structure and gene expression are dynamically controlled by post-translational modifications (PTMs) on histone proteins, including ubiquitylation, methylation, acetylation and small ubiquitin-like modifier (SUMO) conjugation.
Hong-Yeoul Ryu, Mark Hochstrasser
openaire   +2 more sources

Smc5/6: a link between DNA repair and unidirectional replication? [PDF]

, 2008
Of the three structural maintenance of chromosome (SMC) complexes, two directly regulate chromosome dynamics. The third, Smc5/6, functions mainly in homologous recombination and in completing DNA replication.
A Losada, Antony M. Carr, AR Lehmann, B Hu, D Branzei, D Ivanov, DM Sheedy, E Ampatzidou, E Unal, E Unal, EA Andrews, ES Chen, F Onoda, G De Piccoli, GJ Cost, H Morikawa, HB Lindroos, HM Verkade, I Miyabe, J Palecek, J Rouse, J Sergeant, J Torres-Rosell, J Torres-Rosell, JK Chin, Johanne M. Murray, KL Borden, KM Lee, L Strom, L Strom, MI Fousteri, MN Boddy, N Aono, PR Potts, PR Potts, PR Potts, S Pebernard, S Pebernard, SH Harvey, T de Lange, T Kobayashi, T Mengiste, T Morishita, TM Roberts, WH McDonald, WM Thorburn, X Zhao   +46 more
core   +1 more source