Results 71 to 80 of about 37,758 (275)

SUMOylation in the control of cholesterol homeostasis [PDF]

Open Biology, 2020
SUMOylation—protein modification by the small ubiquitin-related modifier (SUMO)—affects several cellular processes by modulating the activity, stability, interactions or subcellular localization of a variety of substrates. SUMO modification is involved in most cellular processes required for the maintenance of metabolic homeostasis.
Orhi Barroso-Gomila, Marco Grillo, Marco Grillo, Ana Talamillo, Leiore Ajuria, Rosa Barrio, Ugo Mayor, Ugo Mayor   +7 more
openaire   +5 more sources

Correlationship between total proteins SUMOylation and papillary thyroid carcinoma in males [PDF]

Waike lilun yu shijian
Objective To investigate the relationship between protein SUMOylation level and the prognosis of papillary thyroid carcinoma(PTC) in males. Methods Protein SUMOylation levels in PTC was analyzed by bioinformatics based on GTEx and TCGA databases and ...
WU Qiao, LIU Wei, ZHENG Jiaojiao, WANG Cong, AI Zhilong
doaj   +1 more source

Protein SUMOylation modification and its associations with disease [PDF]

Open Biology, 2017
SUMOylation, as a post-translational modification, plays essential roles in various biological functions including cell growth, migration, cellular responses to stress and tumorigenesis.
Yanfang Yang, Yu He, Xixi Wang, Ziwei liang, Gu He, Peng Zhang, Hongxia Zhu, Ningzhi Xu, Shufang Liang   +8 more
doaj   +1 more source

SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis

Nature Communications, 2020
Farnesoid X receptor (FXR) is a promising target for nonalcoholic steatohepatitis (NASH) and fibrosis. Although various FXR agonists have shown anti-fibrotic effects in diverse preclinical animal models, the response rate and efficacies in clinical ...
Jiyu Zhou, Shuang Cui, Q. He, Yitong Guo, Xiaojie Pan, Pengfei Zhang, Ningning Huang, Chaoliang Ge, Guangji Wang, F. Gonzalez, Hong Wang, H. Hao   +11 more
semanticscholar   +1 more source

SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites

Nucleic Acids Research, 2021
Glucocorticoid receptor (GR) is an essential transcription factor (TF), controlling metabolism, development and immune responses. SUMOylation regulates chromatin occupancy and target gene expression of GR in a locus-selective manner, but the mechanism of
Ville Paakinaho, Joanna K. Lempiäinen, Gianluca Sigismondo, E. Niskanen, M. Malinen, T. Jääskeläinen, M. Varjosalo, J. Krijgsveld, J. Palvimo   +8 more
semanticscholar   +1 more source

Dynamic sumoylation of promoter-bound general transcription factors facilitates transcription by RNA polymerase II.

PLoS Genetics, 2021
Transcription-related proteins are frequently identified as targets of sumoylation, including multiple subunits of the RNA polymerase II (RNAPII) general transcription factors (GTFs).
Mohammad S Baig, Yimo Dou, Benjamin G Bergey, Russell Bahar, Justin M Burgener, Marjan Moallem, James B McNeil, Akhi Akhter, Giovanni L Burke, Veroni S Sri Theivakadadcham, Patricia Richard, Damien D'Amours, Emanuel Rosonina   +12 more
doaj   +1 more source

Viruses, SUMO, and immunity: the interplay between viruses and the host SUMOylation system

Journal of Neurovirology, 2021
The conjugation of small ubiquitin-like modifier (SUMO) proteins to substrates is a well-described post-translational modification that regulates protein activity, subcellular localization, and protein–protein interactions for a variety of downstream ...
Fergan Imbert, D. Langford
semanticscholar   +1 more source

SUMOylating Two Distinct Sites on the A-type Potassium Channel, Kv4.2, Increases Surface Expression and Decreases Current Amplitude

Frontiers in Molecular Neuroscience, 2019
Post-translational conjugation of Small Ubiquitin-like Modifier (SUMO) peptides to lysine (K) residues on target proteins alters their interactions. SUMOylation of a target protein can either promote its interaction with other proteins that possess SUMO ...
Meghyn A. Welch, Lori A. Forster, Selin I. Atlas, Deborah J. Baro, Deborah J. Baro   +4 more
doaj   +1 more source

SUMOylation as a Therapeutic Target for Myocardial Infarction

Frontiers in Cardiovascular Medicine, 2021
Myocardial infarction is a prevalent and life-threatening cardiovascular disease. The main goal of existing interventional therapies is to restore coronary reperfusion while few are designed to ameliorate the pathology of heart diseases via targeting the
Wei Zhao, Xiuying Zhang, J. Rong
semanticscholar   +1 more source

SUMOylation of the Kv4.2 Ternary Complex Increases Surface Expression and Current Amplitude by Reducing Internalization in HEK 293 Cells

Frontiers in Molecular Neuroscience, 2021
Kv4 α-subunits exist as ternary complexes (TC) with potassium channel interacting proteins (KChIP) and dipeptidyl peptidase-like proteins (DPLP); multiple ancillary proteins also interact with the α-subunits throughout the channel’s lifetime.
Meghyn A. Welch, Leslie-Anne R. Jansen, Deborah J. Baro, Deborah J. Baro   +3 more
doaj   +1 more source