Results 1 to 10 of about 19,250 (186)

Depletion of SUN1/2 induces heterochromatin accrual in mesenchymal stem cells during adipogenesis [PDF]

Communications Biology, 2022
Critical to the mechano-regulation of mesenchymal stem cells (MSC), Linker of the Nucleoskeleton and Cytoskeleton (LINC) complex transduces cytoskeletal forces to the nuclei.
Matthew Goelzer, Sean Howard, Anamaria G. Zavala, Daniel Conway, Janet Rubin, Andre J. van Wijnen, Gunes Uzer   +6 more
doaj   +5 more sources

Nuclear restriction of HIV-1 infection by SUN1 [PDF]

Scientific Reports, 2021
Overexpression of the human Sad-1-Unc-84 homology protein 2 (SUN2) blocks HIV-1 infection in a capsid-dependent manner. In agreement, we showed that overexpression of SUN1 (Sad1 and UNC-84a) also blocks HIV-1 infection in a capsid-dependent manner.
Mirjana Persaud, Anastasia Selyutina, Cindy Buffone, Silvana Opp, Daniel A. Donahue, Oliver Schwartz, Felipe Diaz-Griffero   +6 more
doaj   +3 more sources

Elevated SUN1 promotes migratory cell polarity defects through mechanically coupling microtubules to the nuclear lamina [PDF]

Communications Biology
In migratory fibroblasts, front-rear polarity is defined by the centrosome positioned anterior to a rearward nucleus. To achieve this polarity, actin cables couple to nuclear membrane proteins nesprin-2G and SUN2 and drive the nucleus backward.
Yutao Li, Yicong Zhang, Mengqi Chen, Susumu Antoku, Junjun Ding, Kaiyao Huang, Gregg G. Gundersen, Wakam Chang   +7 more
doaj   +2 more sources

Inner Nuclear Membrane Protein, SUN1, is Required for Cytoskeletal Force Generation and Focal Adhesion Maturation

Frontiers in Cell and Developmental Biology, 2022
The linker of nucleoskeleton and cytoskeleton (LINC) complex is composed of the inner nuclear membrane-spanning SUN proteins and the outer nuclear membrane-spanning nesprin proteins.
Nanami Ueda, Masashi Maekawa, Masashi Maekawa, Masashi Maekawa, Tsubasa S. Matsui, Shinji Deguchi, Tomoyo Takata, Jun Katahira, Shigeki Higashiyama, Shigeki Higashiyama, Shigeki Higashiyama, Miki Hieda   +11 more
doaj   +3 more sources

Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation

eLife, 2023
Endothelial cells line all blood vessels, where they coordinate blood vessel formation and the blood-tissue barrier via regulation of cell-cell junctions.
Danielle B Buglak, Pauline Bougaran, Molly R Kulikauskas, Ziqing Liu, Elizabeth Monaghan-Benson, Ariel L Gold, Allison P Marvin, Andrew Burciu, Natalie T Tanke, Morgan Oatley, Shea N Ricketts, Karina Kinghorn, Bryan N Johnson, Celia E Shiau, Stephen Rogers, Christophe Guilluy, Victoria L Bautch   +16 more
doaj   +3 more sources

A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei [PDF]

eLife
Mitosis in eukaryotes involves reorganisation of the nuclear envelope (NE) and microtubule-organising centres (MTOCs). During male gametogenesis in Plasmodium, the causative agent of malaria, mitosis is exceptionally rapid and highly divergent.
Mohammad Zeeshan, Igor Blatov, Ryuji Yanase, David JP Ferguson, Sarah L Pashley, Zeinab Chahine, Yoshiki Yamaryo-Botté, Akancha Mishra, Baptiste Marche, Suhani Bhanvadia, Molly Hair, Sagar Batra, Robert Markus, Declan Brady, Andrew R Bottrill, Sue Vaughan, Cyrille Y Botté, Karine G Le Roch, Anthony A Holder, Eelco Tromer, Rita Tewari   +20 more
doaj   +2 more sources

Tension-sensitive LINC-RhoA signaling prevents chromatin bridge breakage in cytokinesis [PDF]

The EMBO Journal
In the presence of chromatin bridges in cytokinesis, human cells retain actin-rich structures (actin patches) at the base of the intercellular canal to prevent chromosome breakage.
Sofia Balafouti, Maria Kabouraki, George Zachos, Eleni Petsalaki   +3 more
doaj   +2 more sources

Dictyostelium spastin is involved in nuclear envelope dynamics during semi-closed mitosis

Nucleus, 2022
Dictyostelium amoebae perform a semi-closed mitosis, in which the nuclear envelope is fenestrated at the insertion sites of the mitotic centrosomes and around the central spindle during karyokinesis.
Ulrike Schweigel, Petros Batsios, Annette Müller-Taubenberger, Ralph Gräf, Marianne Grafe   +4 more
doaj   +1 more source

Tethering of Telomeres to the Nuclear Envelope Is Mediated by SUN1-MAJIN and Possibly Promoted by SPDYA-CDK2 During Meiosis

Frontiers in Cell and Developmental Biology, 2020
During meiosis, telomeres attach to the nuclear envelope (NE) to promote homologous chromosome moving, pairing, synapsis, and recombination. The telomere-NE attachment is mediated by SUN1, TERB1-TERB2-MAJIN (TTM complex), and TRF1. The interaction of the
Guishuan Wang, Xiaolong Wu, Liwei Zhou, Sheng Gao, Damin Yun, Ajuan Liang, Fei Sun   +6 more
doaj   +1 more source

Inhibition of HIV infection by structural proteins of the inner nuclear membrane is associated with reduced chromatin dynamics

Cell Reports, 2021
Summary: The human immunodeficiency virus (HIV) enters the nucleus to establish infection, but the role of nuclear envelope proteins in this process is incompletely understood.
Anvita Bhargava, Alice Williart, Mathieu Maurin, Patricia M. Davidson, Mabel Jouve, Matthieu Piel, Xavier Lahaye, Nicolas Manel   +7 more
doaj   +1 more source