Results 11 to 20 of about 19,250 (186)
Sun1 deficiency leads to cerebellar ataxia in mice [PDF]
Disease Models & Mechanisms, 2015 Migration and organization of the nucleus are essential for the proliferation and differentiation of cells, including neurons. However, the relationship between the positioning of the nucleus and cellular morphogenesis remains poorly understood ...
Jing-Ya Wang +7 more
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SUN1/2 controls macrophage polarization via modulating nuclear size and stiffness
Nature Communications, 2023 Alteration of the size and stiffness of the nucleus triggered by environmental cues are thought to be important for eukaryotic cell fate and function.
Shi Jiao +10 more
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Data on the association of the nuclear envelope protein Sun1 with nucleoli
Data in Brief, 2017 SUN proteins participate in diverse cellular activities, many of which are connected to the nuclear envelope. Recently, the family member SUN1 has been linked to novel biological activities.
Ossama Moujaber +6 more
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From loss to gain: role for SUN1 in laminopathies [PDF]
Cell & Bioscience, 2012 Mutations in LMNA encoding lamins A and C are associated with at least 10 different degenerative disorders affecting diverse tissues, collectively called laminopathies.
Liu Baohua, Jin Dong-Yan, Zhou Zhongjun
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The SUN1-SPDYA interaction plays an essential role in meiosis prophase I [PDF]
Nature Communications, 2021 Telomeres attach to the nuclear envelope to facilitate homolog pairing during meiosis prophase I. Here, the authors show that SUN1 and SPDYA interact, and demonstrate that this interaction is important for telomere structure and function, and essential ...
Yanyan Chen +13 more
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Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization. [PDF]
PLoS Genetics, 2014 Proteins of the nuclear envelope (NE) are associated with a range of inherited disorders, most commonly involving muscular dystrophy and cardiomyopathy, as exemplified by Emery-Dreifuss muscular dystrophy (EDMD).
Peter Meinke +10 more
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Cells, 2020 Vascular smooth muscle cells (VSMCs) are the predominant cell type in the blood vessel wall. Changes in VSMC actomyosin activity and morphology are prevalent in cardiovascular disease. The actin cytoskeleton actively defines cellular shape and the LInker
Lauren Porter +12 more
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eLife, 2019 Here we show that a major muscle specific isoform of the murine LINC complex protein SUN1 is required for efficient muscle regeneration. The nucleoplasmic domain of the isoform specifically binds to and inhibits Drosha, a key component of the ...
Tsui Han Loo +6 more
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The nuclear envelope localization of DYT1 dystonia torsinA-ΔE requires the SUN1 LINC complex component [PDF]
BMC Cell Biology, 2011 Background DYT1 dystonia is an autosomal dominant neurological condition caused by a mutation that removes a single glutamic acid residue (ΔE) from the torsinA (torA) AAA+ protein.
Jeong Danielle Y +3 more
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Dialing Down SUN1 for Laminopathies [PDF]
Cell, 2012 Laminopathies, caused by mutations in A-type nuclear lamins, encompass a range of diseases, including forms of progeria and muscular dystrophy. In this issue, Chen et al. provide evidence that elevated expression of the nuclear inner membrane protein SUN1 drives pathology in multiple laminopathies.
Suh, Yousin, Kennedy, Brian K.
openaire +5 more sources