Results 21 to 30 of about 19,250 (186)

Disruption of Nuclear‐Cytoskeletal Linkage by Coil‐1a LMNA Mutations in Emery–Dreifuss Muscular Dystrophy [PDF]

Journal of Cachexia
ABSTRACT Background Emery–Dreifuss muscular dystrophy (EDMD) is a progressive genetic myopathy that mainly affects the muscles used for movement (skeletal muscles) and the heart (cardiac muscles). The disease is frequently associated with mutations in genes encoding nuclear envelope proteins, most notably LMNA, which encodes lamin A—a critical ...
Kang S, Kim R, Woo T, Park S, Ji Y, Kim H, Jeong Y, Kim J, Kim Y, Chang W, Kim B, Park B.   +11 more
europepmc   +2 more sources

Functional association of Sun1 with nuclear pore complexes [PDF]

The Journal of Cell Biology, 2007
Sun1 and 2 are A-type lamin-binding proteins that, in association with nesprins, form a link between the inner nuclear membranes (INMs) and outer nuclear membranes of mammalian nuclear envelopes. Both immunofluorescence and immunoelectron microscopy reveal that Sun1 but not Sun2 is intimately associated with nuclear pore complexes (NPCs).
Liu, Qian, Pante, Nelly, Misteli, Tom, Elsagga, Mohamed, Crisp, Melissa, Hodzic, Didier, Burke, Brian, Roux, Kyle J.   +7 more
openaire   +3 more sources

The SUN1 splicing variants SUN1_888 and SUN1_916 differentially regulate nucleolar structure [PDF]

Genes to Cells, 2020
AbstractThe nucleolar structure is highly dynamic and strictly regulated in response to internal cues, such as metabolic rates, and to external cues, such as mechanical forces applied to cells. Although the multilayered nucleolar structure is largely determined by the liquid‐like properties of RNA and proteins, the mechanisms regulating the morphology ...
Erina Satomi, Masako Ueda, Jun Katahira, Miki Hieda   +3 more
openaire   +2 more sources

Reversal of laminopathies: the curious case of SUN1 [PDF]

Nucleus, 2012
Mutations in the LMNA gene are associated with a spectrum of human dystrophic diseases termed the "nuclear laminopathies." We recently found that the accumulation of the inner nuclear envelope proteins SUN1 is pathogenic in progeric and dystrophic laminopathies. This conclusion arose from the unexpected observation that the deletion of Sun1, instead of
Ya-Hui, Chi, Chia-Yen, Chen, Kuan-Teh, Jeang   +2 more
openaire   +2 more sources

Differential incorporation of SUN-domain proteins into LINC complexes is coupled to gene expression. [PDF]

PLoS ONE, 2018
LInkers of Nucleoskeleton and Cytoskeleton (LINC) complexes, composed of SUN and KASH-domain proteins, span the nuclear envelope and physically connect the nuclear interior to cytoskeletal elements.
Christopher K May, Christopher W Carroll
doaj   +1 more source

Nuclear pore complexes concentrate on Actin/LINC/Lamin nuclear lines in response to mechanical stress in a SUN1 dependent manner

Heliyon, 2022
Formation of robust actomyosin stress fibers (SF) in response to cell stretch plays a key role in the transfer of information from the cytoplasm into the nucleus.
Mark A. Smith, Elizabeth Blankman, Christopher C. Jensen, Laura M. Hoffman, Katharine S. Ullman, Mary C. Beckerle   +5 more
doaj   +1 more source

The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal

Scientific Reports, 2021
The morphology of the Golgi complex is influenced by the cellular context, which strictly correlates with nuclear functions; however, the mechanism underlying this association remains elusive.
Miki Hieda, Taizo Matsumoto, Mari Isobe, Sadamu Kurono, Kaneko Yuka, Satoshi Kametaka, Jing-Ya Wang, Ya-Hui Chi, Kenji Kameda, Hiroshi Kimura, Nariaki Matsuura, Shuji Matsuura   +11 more
doaj   +1 more source

Molecular insights into LINC complex architecture through the crystal structure of a luminal trimeric coiled-coil domain of SUN1

Frontiers in Cell and Developmental Biology, 2023
The LINC complex, consisting of interacting SUN and KASH proteins, mechanically couples nuclear contents to the cytoskeleton. In meiosis, the LINC complex transmits microtubule-generated forces to chromosome ends, driving the rapid chromosome movements ...
Manickam Gurusaran, Jelle J. Biemans, Christopher W. Wood, Owen R. Davies   +3 more
doaj   +1 more source

First observation of the M1 transition $\psi(3686)\to \gamma\eta_c(2S)$ [PDF]

, 2012
Using a sample of 106 million \psi(3686) events collected with the BESIII detector at the BEPCII storage ring, we have made the first measurement of the M1 transition between the radially excited charmonium S-wave spin-triplet and the radially excited S ...
A. A. Zafar, A. Calcaterra, A. Denig, A. Q. Guo, A. Sarantsev, A. Zallo, A. Zhemchugov, B. D. Schaefer, B. Huang, B. J. Liu, B. J. Liu, B. Q. Wang, B. S. Zou, B. Spruck, B. Wang, B. X. Yu, B. X. Zhang, B. Y. Zhang, B. Zheng, B. Zhong, C. C. Zhang, C. D. Fu, C. F. Qiao, C. Geng, C. H. Li, C. J. Tang, C. L. Liu, C. L. Luo, C. L. Ma, C. Morales Morales, C. Motzko, C. Nicholson, C. P. Shen, C. Q. Feng, C. S. J. Pun, C. S. Ji, C. X. Liu, C. X. Yu, C. Y. Liu, C. Z. Yuan, C. Zhu, Cheng Li, Cui Li, D. Cronin-Hennessy, D. Dedovich, D. H. Sun, D. H. Wei, D. H. Zhang, D. J. Ambrose, D. M. Li, D. P. Jin, D. Toth, E. Boger, E. H. Thorndike, E. Prencipe, F. A. Harris, F. C. Ma, F. E. Maas, F. F. An, F. F. Jing, F. Feldbauer, F. H. Liu, F. Li, F. Xue, Fang Liu, Feng Liu, G. Chelkov, G. Chen, G. F. Cao, G. F. Xu, G. Li, G. M. Huang, G. M. Xu, G. R. Liao, G. R. Lu, G. Rong, G. S. Varner, G. X. Sun, G. Zhao, H. B. Li, H. B. Liu, H. H. Liu, H. H. Zhang, H. J. Lu, H. L. Dai, H. L. Ma, H. L. Tian, H. Liang, H. Liu, H. Loehner, H. M. Hu, H. M. Liu, H. Mao, H. Nakazawa, H. P. Cheng, H. P. Peng, H. S. Chen, H. S. Zhao, H. W. Liu, H. X. Yang, H. Xu, H. Y. Sheng, H. Y. Zhang, H. Ye, I. B. Nikolaev, I. Boyko, I. Denysenko, J. B. Jiao, J. Becker, J. C. Chen, J. C. Li, J. F. Chang, J. F. Hu, J. F. Qiu, J. F. Sun, J. Fang, J. G. Lu, J. G. Messchendorp, J. G. Zhang, J. H. Zou, J. K. C. Leung, J. L. Fu, J. L. Ping, J. M. Bian, J. Min, J. P. Dai, J. P. Liu, J. P. Zheng, J. Q. Zhang, J. S. Huang, J. S. Lange, J. S. Yu, J. Schulze, J. W. Park, J. W. Zhang, J. W. Zhao, J. X. Zuo, J. Y. Zhang, J. Z. Bai, J. Z. Zhang, J. Zhang, J. Zhong, J. Zhuang, K. Goetzen, K. H. Rashid, K. J. Zhu, K. L. He, K. Li, K. Peters, K. Wang, K. X. Zhao, K. Y. Liu, K. Zhu, Kai Liu, Kun Liu, L. B. Guo, L. Fava, L. G. Xia, L. H. Wu, L. K. Jia, L. L. Jiang, L. L. Wang, L. S. Wang, L. Y. Dong, L. Yan, L. Yu, L. Zhang, L. Zhou, Lei Li, Lei Zhao, Ling Zhao, M. Ablikim, M. Bertani, M. Destefanis, M. G. Zhao, M. Greco, M. H. Gu, M. H. Ye, M. He, M. Kavatsyuk, M. L. Chen, M. Lv, M. Maggiora, M. N. Achasov, M. Pelizaeus, M. Qi, M. R. Shepherd, M. Shao, M. Ullrich, M. Wang, M. Werner, M. X. Luo, M. Y. Dong, M. Ye, N. B. Li, N. Berger, N. Kalantar-Nayestanaki, N. Wu, N. Yu. Muchnoi, O. Bondarenko, P. L. Liu, P. L. Wang, P. Wang, P. Weidenkaff, Q. A. Malik, Q. An, Q. G. Wen, Q. J. Li, Q. J. Wang, Q. J. Xu, Q. Ji, Q. L. Xiu, Q. M. Ma, Q. Ouyang, Q. W. Lu, Q. Wang, Q. Zhao, R. A. Briere, R. B. Ferroli, R. E. Mitchell, R. G. Ping, R. Poling, S. B. Liu, S. G. Wang, S. H. Zhang, S. H. Zhu, S. J. Chen, S. J. Zhao, S. Jin, S. L. Li, S. L. Olsen, S. Ma, S. P. Wen, S. P. Yu, S. Pacetti, S. Qian, S. S. Fang, S. S. Sun, S. Spataro, S. X. Du, S. X. Wu, T. C. Zhao, T. Held, T. Hu, T. Hussain, T. J. Min, T. Luo, T. Ma, T. R. Zhang, T. Yang, U. Wiedner, V. Bytev, W. B. Yan, W. D. Li, W. G. Li, W. Gradl, W. Kuehn, W. L. Yuan, W. Lai, W. M. Ding, W. Wu, W. X. Gong, X. B. Ji, X. Cai, X. D. Ruan, X. D. Sun, X. F. Wang, X. H. Liu, X. H. Mo, X. H. Zhao, X. J. Zhang, X. K. Zhou, X. L. Ji, X. L. Li, X. L. Luo, X. L. Wang, X. L. Zhu, X. Liu, X. N. Li, X. P. Xu, X. Q. Hao, X. Q. Li, X. R. Li, X. R. Lu, X. R. Zhou, X. S. Jiang, X. S. Qin, X. T. Huang, X. T. Liao, X. Tang, X. W. Zhu, X. Y. Ma, X. Y. Shen, X. Y. Song, X. Y. Zhang, Y. B. Chen, Y. B. Liu, Y. B. Zhao, Y. Ban, Y. Chen, Y. D. Wang, Y. Ding, Y. F. Liang, Y. F. Wang, Y. G. Xie, Y. Gao, Y. H. Guan, Y. H. Yan, Y. H. Zhang, Y. H. Zheng, Y. J. Mao, Y. J. Sun, Y. K. Heng, Y. L. Han, Y. Liu, Y. M. Zhu, Y. Ma, Y. Nefedov, Y. P. Chu, Y. P. Guo, Y. P. Huang, Y. P. Lu, Y. Q. Wang, Y. Qin, Y. S. Zhang, Y. S. Zhu, Y. T. Gu, Y. T. Liang, Y. X. Yang, Y. Xu, Y. Yang, Y. Yuan, Y. Z. Sun, Y. Zeng, Y. Zhang, Z. A. Liu, Z. A. Zhu, Z. B. Li, Z. G. Wang, Z. G. Zhao, Z. H. An, Z. H. Qin, Z. J. Sun, Z. J. Xiao, Z. Jiao, Z. L. Hou, Z. Ning, Z. P. Mao, Z. P. Zhang, Z. P. Zheng, Z. R. Xu, Z. T. Sun, Z. Wang, Z. Wu, Z. Xue, Z. Y. Deng, Z. Y. He, Z. Y. Wang, Z. Y. Zhang, Zhiqiang Liu, Zhiqing Liu   +360 more
core   +8 more sources

Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy

Nature Communications, 2021
Mutations in the LaminA gene are the second most common inherited cause of Dilated Cardiomyopathy, a major form of heart failure. Here the authors show that disruption of the nuclear protein SUN1 in cardiomyocytes, by AAV mediated transduction of a SUN1 ...
Ruth Jinfen Chai, Hendrikje Werner, Peter Yiqing Li, Yin Loon Lee, Khaing Thet Nyein, Irina Solovei, Tuan Danh Anh Luu, Bhavya Sharma, Raju Navasankari, Martina Maric, Lois Yu En Sim, Ying Jie Loh, Edita Aliwarga, Jason Wen Long Cheong, Alexandre Chojnowski, Matias Ilmari Autio, Yu Haiyang, Kenneth Kian Boon Tan, Choong Tat Keng, Shi Ling Ng, Wei Leong Chew, Michael Ferenczi, Brian Burke, Roger Sik Yin Foo, Colin L. Stewart   +24 more
doaj   +1 more source