Results 1 to 10 of about 620,257 (337)

Zinc Supplementation Combats Tuberculosis by Reverting Back to Normal Compartmentalized State of Iron and Hence Increasing Blood Hemoglobin Concentration [PDF]

Indian Journal of Medical Biochemistry, 2023
Aim and background: To acquire iron (Fe), Mycobacterium tuberculosis (Mtb) expresses high-affinity Fe+3-specific siderophores for scavenging Fe from host insoluble and protein-bound iron-like transferrin, lactoferrin, ferritin, and hemoglobin−haptoglobin.
Dipak Kumar Chattopadhyay
doaj   +1 more source

Examining the Antioxidant and Superoxide Radical Scavenging Activity of Anise, (Pimpinella anisum L. Seeds), Esculetin, and 4-Methyl-Esculetin Using X-ray Diffraction, Hydrodynamic Voltammetry and DFT Methods

Pharmaceuticals, 2023
Pimpinella anisum L., or anise, is a plant that, besides its nutritional value, has been used in traditional medical practices and described in many cultures in the Mediterranean region. A possible reason for anise’s therapeutic value is that it contains
Miriam Rossi, Francesco Caruso, Natalie Thieke, Stuart Belli, Alana Kim, Elisabetta Damiani, Camilla Morresi, Tiziana Bacchetti   +7 more
doaj   +1 more source

The Labile Iron Pool Reacts Rapidly and Catalytically with Peroxynitrite

Biomolecules, 2021
While investigating peroxynitrite-dependent oxidation in murine RAW 264.7 macrophage cells, we observed that removal of the Labile Iron Pool (LIP) by chelation increases the intracellular oxidation of the fluorescent indicator H2DCF, so we concluded that
André Luís Condeles, José Carlos Toledo Junior   +1 more
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Functional interactions between NADPH oxidase 5 and actin

Frontiers in Cell and Developmental Biology, 2023
NADPH oxidase 5 (NOX5) is a transmembrane oxidative signaling enzyme which produces superoxide in response to intracellular calcium flux. Increasing evidence indicates that NOX5 is involved in a variety of physiological processes as well as human disease,
Samantha M. Richter, Lilyanna C. Massman, Dennis J. Stuehr, Elizabeth A. Sweeny   +3 more
doaj   +1 more source

^•BMPO-OOH Spin-Adduct as a Model for Study of Decomposition of Organic Hydroperoxides and the Effects of Sulfide/Selenite Derivatives. An EPR Spin-Trapping Approach

Antioxidants, 2020
Lipid hydroperoxides play an important role in various pathophysiological processes. Therefore, a simple model for organic hydroperoxides could be helpful to monitor the biologic effects of endogenous and exogenous compounds.
Anton Misak, Vlasta Brezova, Marian Grman, Lenka Tomasova, Miroslav Chovanec, Karol Ondrias   +5 more
doaj   +1 more source

Soybean-Derived Tripeptide Leu–Ser–Trp (LSW) Protects Human Vascular Endothelial Cells from TNFα-Induced Oxidative Stress and Inflammation via Modulating TNFα Receptors and SIRT1

Foods, 2022
Soybean is a rich source of high-quality proteins and an excellent food source of bioactive peptides. A tripeptide, Leu–Ser–Trp (LSW), was previously identified from soybean as an angiotensin-converting enzyme inhibitory peptide.
Hongbing Fan, Khushwant S. Bhullar, Zihan Wang, Jianping Wu   +3 more
doaj   +1 more source

Structural Evidence for a Copper-Bound Carbonate Intermediate in the Peroxidase and Dismutase Activities of Superoxide Dismutase [PDF]

, 2012
Copper-zinc superoxide dismutase (SOD) is of fundamental importance to our understanding of oxidative damage. Its primary function is catalysing the dismutation of superoxide to O2 and H2O2. SOD also reacts with H2O2, leading to the formation of a strong
Luis Eduardo Soares Netto, Michael A. Hough, Richard W. Strange, S. Samar Hasnain, Svetlana V. Antonyuk   +4 more
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Effect of 7-nitroindazoleon superoxide production and MnSOD activity in threat brain following kainate-induced neurotoxicity [PDF]

Archives of Biological Sciences, 2008
We investigated the effect of 7-nitroindazole (7-NI), a selective neuronal nitric oxide synthase inhibitor in vivo, on superoxide concentration as well its influence on mitochondrial MnSOD activity since this activity is associated with the production of
Radenović Lidija
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EPR Study of KO₂ as a Source of Superoxide and ^•BMPO-OH/OOH Radical That Cleaves Plasmid DNA and Detects Radical Interaction with H₂S and Se-Derivatives

Antioxidants, 2021
Superoxide radical anion (O2•−) and its derivatives regulate numerous physiological and pathological processes, which are extensively studied. The aim of our work was to utilize KO2 as a source of O2•− and the electron paramagnetic resonance (EPR) spin ...
Anton Misak, Vlasta Brezova, Miroslav Chovanec, Karol Luspai, Muhammad Jawad Nasim, Marian Grman, Lenka Tomasova, Claus Jacob, Karol Ondrias   +8 more
doaj   +1 more source

The Non-Specific Drp1 Inhibitor Mdivi-1 Has Modest Biochemical Antioxidant Activity

Antioxidants, 2022
Mitochondrial division inhibitor-1 (mdivi-1), a non-specific inhibitor of Drp1-dependent mitochondrial fission, is neuroprotective in numerous preclinical disease models.
Evan A. Bordt, Naibo Zhang, Jaylyn Waddell, Brian M. Polster   +3 more
doaj   +1 more source