Results 81 to 90 of about 588,242 (306)

Cytochrome c and superoxide [PDF]

JBIC Journal of Biological Inorganic Chemistry, 2013
ISSN:0949 ...
openaire   +4 more sources

Adiponectin protects against paraquat-induced lung injury by attenuating oxidative/nitrative stress. [PDF]

, 2014
The specific mechanisms underlying paraquat (PQ)-induced lung injury remain unknown, which limits understanding of its cytotoxic potential. Although oxidative stress has been established as an important mechanism underlying PQ toxicity, multiple ...
Cao, Yu, He, Yarong, Jiang, Yaowen, Lau, Wayne Bond, Liu, Peng, Yao, Rong, Ye, Lei, Zeng, Zhi, Zheng, Zhijie, Zhou, Yaxiong   +9 more
core   +2 more sources

Macrophage Membrane‐Cloaked, ROS‐Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome

Advanced Healthcare Materials, EarlyView.
The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li, Yu Guan, Nan Song, Feng Zhang, Zhimin Deng, Tailang Yin, Yanbing Yang, João Conde, Wenyi Jin, Zhinang Yin   +9 more
wiley   +1 more source

Visualizing mitochondrial FoF1-ATP synthase as the target of the immunomodulatory drug Bz-423

, 2018
Targeting the mitochondrial enzyme FoF1-ATP synthase and modulating its catalytic activities with small molecules is a promising new approach for treatment of autoimmune diseases. The immuno-modulatory compound Bz-423 is such a drug that binds to subunit
Börsch, Michael, Glick, Gary D., Starke, Ilka   +2 more
core   +1 more source

Infection of the brown alga Ectocarpus siliculosus by the oomycete Eurychasma dicksonii induces oxidative stress and halogen metabolism [PDF]

, 2016
Acknowledgments We would like to thank the Aberdeen Proteome Facility, especially Phil Cash, David Stead and Evelyn Argo for assistance with 2D electrophoresis and mass spectrometry. M.S.
Asada, Austin, Bhadauria, Bouarab, Bréhélin, Butler, Chen, Chen, Cock, Cock, Collén, Contreras, Cosse, Crépineau, Dantuma, Dittami, Farmer, Farnham, Fosu-Nyarko, Franco, Gachon, Gachon, Goulitquer, Grenville-Briggs, Grenville-Briggs, Grenville-Briggs, Grenville-Briggs, Gschloessl, Heesch, Kav, Klochkova, Konotchick, Küpper, Küpper, Küpper, Küpper, Küpper, Küpper, Küpper, Küpper, Küpper, La Barre, Langenkämper, Le Bail, Matros, Mayer, Mithöfer, Müller, Nelson, Orozco-Cárdenas, Palmer, Park, Paul, Pearson, Pfaffl, Potin, Ritter, Roeder, Roy, Salgado, Santino, Schmidt, Sekimoto, Singh, Strittmatter, Strittmatter, Tan, Thomas, Thomas, Tonon, Tsirigoti, Tsirigoti, Uppalapati, Vidi, Vizcaíno, Weinberger, Weinberger, Weinberger, West, West, Yang, Youssef, Ytterberg, Zambounis, Zhou   +84 more
core   +1 more source

Biomimetic Copper Nanoparticles Coated with ACE2‐Overexpressing Membranes for Selective SARS‐CoV‐2 Neutralization and Disinfection

Advanced Healthcare Materials, EarlyView.
By fusing ACE2‐overexpressing membrane‐integrated liposome (MIL) with copper nanoparticles, the biomimetic Cu@MIL nanostructures were created that directly hijack the SARS‐CoV‐2 entry pathway. These particles combine potent virus‐targeting precision with intrinsic antiviral activity, achieving rapid neutralization and disinfection.
Pooja Aich, Wei‐Pang Chung, Wen‐Jyun Wang, Hidenobu Takahashi, Ming‐Shun Hsieh, Ying‐Chen Lin, Oh Seok Kwon, Wei‐Peng Li, Wei‐Lun Huang   +8 more
wiley   +1 more source

In adenosine A2B knockouts acute treatment with inorganic nitrate improves glucose disposal, oxidative stress and AMPK signaling in the liver

Frontiers in Physiology, 2015
Rationale: Accumulating studies suggest that nitric oxide (NO) deficiency and oxidative stress are central pathological mechanisms in type 2 diabetes.
Maria ePeleli, Michael eHezel, Christa eZollbrecht, A. Erik G Persson, Jon O Lundberg, Eddie eWeitzberg, Bertil B Fredholm, Mattias eCarlstrom   +7 more
doaj   +1 more source

The conceptus induces a switch in protein expression and activities of superoxide dismutase 1 and 2 in the sheep endometrium during early pregnancy [PDF]

, 2016
Acknowledgements We thank Philippe Bolifraud (INRA, France), Krawiec Angele, Sandra Grange, Laurence Puillet-Anselme (CHU Grenoble, France) and Margaret Fraser (Aberdeen, UK) for their expert technical assistance.
Al-Gubory, K. H., Fowler, P. A., Garrel, C., Sugino, N.   +3 more
core   +2 more sources

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti‐Apoptotic, and Neurotrophic Treatments

Advanced Healthcare Materials, EarlyView.
Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise, Fucen Luo, Borislav Angelov, Yuru Deng, Angelina Angelova   +4 more
wiley   +1 more source

Phase 1b/2a trial of the superoxide dismutase mimetic GC4419 to reduce chemoradiotherapy-induced oral mucositis in patients with oral cavity or oropharyngeal carcinoma [PDF]

, 2018
PURPOSE: To assess the safety of the superoxide dismutase mimetic GC4419 in combination with radiation and concurrent cisplatin for patients with oral cavity or oropharyngeal cancer (OCC) and to assess the potential of GC4419 to reduce severe oral ...
Adkins, Douglas, Agarwala, Sanjiv S, Allen, Bryan G, Anderson, Carryn M, Brill, Jeffrey M, Buatti, John M, Chen, Yuhchyau, Holmlund, Jon T, Lee, Christopher M, Mould, Diane R, Sonis, Stephen T, Sun, Wenqing, Venigalla, Madhavi L, Zhen, Weining   +13 more
core   +2 more sources