Results 21 to 30 of about 9,691 (244)

Nickel-gallate metal–organic framework as an efficient antimicrobial and anticancer agent: in vitro study

open access: yesCancer Nanotechnology, 2023
Gallic acid is a natural antioxidant present in many plants such as tea, sumac, gallnut and other plants. This naturally occurring gallic acid is known to exhibit auto-oxidation under certain conditions, generating several reactive oxygen species (ROS ...
Ahmed. A. G. El-Shahawy   +4 more
doaj   +1 more source

Isorhamnetin Influences the Viability, Superoxide Production and Interleukin-8 Biosynthesis of Human Colorectal Adenocarcinoma HT-29 Cells In Vitro

open access: yesLife, 2023
Isorhamnetin has gained research interest for its anti-inflammatory, anti-proliferative and chemoprotective properties. In this study, human colon adenocarcinoma cells were cultured in the presence or absence of different isorhamnetin concentrations (5 ...
Hana Greifová   +9 more
doaj   +1 more source

Photochemical reactivity of zinc tetraphenylporphyrin induced by nonstoichiometric CdS nanoparticles in 2-propanol

open access: yesInternational Journal of Photoenergy, 2001
The photoreactivity of zinc tetraphenylporphyrin (ZnTPP) in the presence of photoexcited CdS nanoparticles and molecular oxygen in 2-propanol has been revisited.
Alex V. Isarov, John Chrysochoos
doaj   +1 more source

Key problems of the four-dimensional Earth system

open access: yesMatter and Radiation at Extremes, 2020
Compelling evidence indicates that the solid Earth consists of two physicochemically distinct zones separated radially in the middle of the lower mantle at ∼1800 km depth.
Ho-kwang Mao, Wendy L. Mao
doaj   +1 more source

Presenilin mutations deregulate mitochondrial Ca2+ homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans

open access: yeseLife, 2018
Mitochondrial dysfunction and subsequent metabolic deregulation is observed in neurodegenerative diseases and aging. Mutations in the presenilin (PSEN) encoding genes (PSEN1 and PSEN2) cause most cases of familial Alzheimer’s disease (AD); however, the ...
Shaarika Sarasija   +5 more
doaj   +1 more source

Arginine-specific gingipains (RgpA/RgpB) knockdown modulates neutrophil machinery

open access: yesJournal of Oral Microbiology
Background Gingipains are important virulence factors present in Porphyromonas gingivalis. Arginine-specific gingipains (RgpA and RgpB) are critically associated with increased proteolytic activity and immune system dysfunction, including neutrophilic ...
Vanessa Tubero Euzebio Alves   +6 more
doaj   +1 more source

Nitrate Increases Aluminum Toxicity and Accumulation in Root of Wheat

open access: yesAgriculture, 2022
Aluminum (Al) toxicity inhibits root growth, while nitrogen is an essential nutrient for plant growth and development. To explore the effects of nitrate (N) on Al toxicity and accumulation in root of wheat, two wheat genotypes, Shengxuan 6 hao (SX6, Al ...
Yan Ma   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Extracellular superoxide dismutase VdSOD5 is required for virulence in Verticillium dahliae

open access: yesJournal of Integrative Agriculture, 2021
Plants produce reactive oxygen species (ROS) to defend pathogens. To counteract this attack, certain pathogens express superoxide dismutases (SODs) to scavenge host-derived ROS.
Li TIAN   +7 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

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