Results 71 to 80 of about 1,702,773 (334)

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Multi agent system for negotiation in supply chain management [PDF]

, 2008
Supply chain management (SCM) is an emerging field that has commanded attention and support from the industrial community. Supply chain (SC) is defined as the chain linking each entity of the manufacturing and supply process from raw materials through to
Makatsoris, C, Saberi, S
core  

An agent-based dynamic information network for supply chain management [PDF]

, 2004
One of the main research issues in supply chain management is to improve the global efficiency of supply chains. However, the improvement efforts often fail because supply chains are complex, are subject to frequent changes, and collaboration and ...
Ahn, H, Lee, H
core   +2 more sources

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Leanness and agility as means for improving supply chains. A case study on Egypt [PDF]

, 2011
Supply chain management has received greater attention from the academics and the practitioners, however the literature review lacks a comprehensive view for supply chain management practices and how its members should act to contribute to its overall ...
El-Tawy, Nesrine, Gallear, D
core  

On the Stability of Supply Chains [PDF]

Operations Research, 2004
This paper examines the stability of decentralized, multistage supply chains under arbitrary demand conditions. It looks for intrinsic properties of the inventory replenishment policies that hold for all customer demand processes and for policies with desirable properties.
openaire   +3 more sources

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Supply chain temple of resilience [PDF]

, 2016
In March 2011, an earthquake and tsunami hit the north-eastern coastline of Japan. Honda, Toyota, Nissan and Subaru all had plants in or close to the affected region, and were forced to close ...
Wilding, Richard D.
core  

Study on the Multi-Equipment Integrated Scheduling Problem of a U-Shaped Automated Container Terminal Based on Graph Neural Network and Deep Reinforcement Learning

Journal of Marine Science and Engineering
Intelligent Guided Vehicles (IGVs) in U-shaped automated container terminals (ACTs) have longer travel paths than those in conventional vertical layout ACTs, and their interactions with double trolley quay cranes (DTQCs) and double cantilever rail cranes
Qinglei Zhang, Yi Zhu, Jiyun Qin, Jianguo Duan, Ying Zhou, Huaixia Shi, Liang Nie   +6 more
doaj   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source