Results 131 to 140 of about 8,443,769 (248)

Why is it taking so long to develop clinically competitive stem cell therapies for CNS disorders?

, 2012
The remarkable advancements in basic stem cell research with implications for several central nervous system disorders have so far not been translated into clinically effective therapies.
Lindvall, Olle, Lindvall, Olle,, Lund University.   +2 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging.

, 2011
SummarySomatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a prerequisite for such function, accumulating data argue for compromised stem cell function with age.
Sigvardsson, Mikael,, Norddahl, Gudmundur L,, Wahlestedt, Martin, Sigvardsson, Mikael, Gudmundur L. Norddahl, Sten, Gerd, Mikael Sigvardsson, Pronk, Kees-Jan, Martin Wahlestedt, Cornelis J. Pronk, Norddahl, Gudmundur, Norddahl, Gudmundur L.,, Wahlestedt, Martin,, David Bryder, Nygren, Jens, Sten, Gerd,, Bryder, David,, Ugale, Amol, Pronk, Cornelis J,, Nygren, Jens M,, Jens M. Nygren, Bryder, David, Amol Ugale, Pronk, Cornelis J.,, Nygren, Jens M.,, Ugale, Amol,, Gerd Sten, Pronk, Kees-Jan,, Norddahl, Gudmundur,, Nygren, Jens,, Lund University.   +30 more
core   +1 more source

Lifting regenerative barriers promotes epithelial cell fate plasticity supporting lineage conversion

Nature Communications
The ability of adult epithelial cells to rewire their cell fate programme in response to injury has emerged as a new paradigm in stem cell biology. This plasticity supersedes the concept of strict stem cell hierarchies, granting cells access to a wider ...
Maria T. Bejar, Paula Jimenez-Gomez, Ilias Moutsopoulos, Harikrishnan Ajith, Bartomeu Colom, Jamie McGinn, Seungmin Han, Greta Skrupskelyte, Fernando J. Calero-Nieto, Berthold Göttgens, Irina I. Mohorianu, Benjamin D. Simons, Maria P. Alcolea   +12 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The gene regulatory landscape driving mouse gonadal supporting cell differentiation. [PDF]

Sci Adv
Stévant I, Abberbock E, Ridnik M, Weiss R, Swisa L, Futtner CR, Maatouk DM, Lovell-Badge R, Malysheva V, Gonen N.   +9 more
europepmc   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea. [PDF]

Sci Adv, 2022
Li XJ, Morgan C, Goff LA, Doetzlhofer A.
europepmc   +1 more source