Results 1 to 10 of about 749,368 (180)
Genetic Control of Mosquitoes: population suppression strategies [PDF]
Revista do Instituto de Medicina Tropical de São Paulo, 2012 Over the last two decades, morbidity and mortality from malaria and dengue fever among other pathogens are an increasing Public Health problem. The increase in the geographic distribution of vectors is accompanied by the emergence of viruses and diseases
André Barretto Bruno Wilke +1 more
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Genetically engineered insects with sex-selection and genetic incompatibility enable population suppression [PDF]
eLife, 2022 Engineered Genetic Incompatibility (EGI) is a method to create species-like barriers to sexual reproduction. It has applications in pest control that mimic Sterile Insect Technique when only EGI males are released.
Ambuj Upadhyay +6 more
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Noise suppression in stochastic genetic circuits using PID controllers.
PLoS Computational Biology, 2021 Inside individual cells, protein population counts are subject to molecular noise due to low copy numbers and the inherent probabilistic nature of biochemical processes.
Saurabh Modi +2 more
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Global analysis of suppressor mutations that rescue human genetic defects
Genome Medicine, 2023 Background Genetic suppression occurs when the deleterious effects of a primary “query” mutation, such as a disease-causing mutation, are rescued by a suppressor mutation elsewhere in the genome.
Betül Ünlü +5 more
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Genetics of Barley Hooded Suppression [PDF]
Genetics, 2004 Abstract The molecular basis of the barley dominant Hooded (K) mutant is a duplication of 305 bp in intron IV of the homeobox gene Bkn3. A chemical mutagenesis screen was carried out to identify genetical factors that participate in Bkn3 intron-mediated gene regulation.
C. Roig +8 more
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Natural variants suppress mutations in hundreds of essential genes
Molecular Systems Biology, 2021 The consequence of a mutation can be influenced by the context in which it operates. For example, loss of gene function may be tolerated in one genetic background, and lethal in another.
Leopold Parts +11 more
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Nonsense Suppression Therapy: An Emerging Treatment for Hereditary Skin Diseases
Acta Dermato-Venereologica, 2022 Nonsense mutations cause the premature termination of protein translation via premature termination codons (PTCs), leading to the synthesis of incomplete functional proteins and causing large numbers of genetic disorders.
Jiangfan Yu +5 more
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Characterization of FtsH Essentiality in Streptococcus mutans via Genetic Suppression
Frontiers in Genetics, 2021 FtsH belongs to the AAA+ ATP-dependent family of proteases, which participate in diverse cellular processes and are ubiquitous among bacteria, chloroplasts, and mitochondria.
Yaqi Wang +5 more
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Inducible Genetic Suppression of Neuronal Excitability [PDF]
The Journal of Neuroscience, 1999 Graded, reversible suppression of neuronal excitability represents a logical goal of therapy for epilepsy and intractable pain. To achieve such suppression, we have developed the means to transfer “electrical silencing” genes into neurons with sensitive control of transgene expression.
D C, Johns +4 more
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Systematic analysis of bypass suppression of essential genes
Molecular Systems Biology, 2020 Essential genes tend to be highly conserved across eukaryotes, but, in some cases, their critical roles can be bypassed through genetic rewiring. From a systematic analysis of 728 different essential yeast genes, we discovered that 124 (17%) were ...
Jolanda van Leeuwen +18 more
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