Results 41 to 50 of about 749,487 (299)

Exploring genetic suppression interactions on a global scale [PDF]

Science, 2016
A global genetic suppression network The genetic background of an organism can influence the overall effects of new genetic variants. Some mutations can amplify a deleterious phenotype, whereas others can suppress it. Starting with a literature survey and expanding into a genomewide assay, van Leeuwen
Jolanda, van Leeuwen, Carles, Pons, Joseph C, Mellor, Takafumi N, Yamaguchi, Helena, Friesen, John, Koschwanez, Mojca Mattiazzi, Ušaj, Maria, Pechlaner, Mehmet, Takar, Matej, Ušaj, Benjamin, VanderSluis, Kerry, Andrusiak, Pritpal, Bansal, Anastasia, Baryshnikova, Claire E, Boone, Jessica, Cao, Atina, Cote, Marinella, Gebbia, Gene, Horecka, Ira, Horecka, Elena, Kuzmin, Nicole, Legro, Wendy, Liang, Natascha, van Lieshout, Margaret, McNee, Bryan-Joseph, San Luis, Fatemeh, Shaeri, Ermira, Shuteriqi, Song, Sun, Lu, Yang, Ji-Young, Youn, Michael, Yuen, Michael, Costanzo, Anne-Claude, Gingras, Patrick, Aloy, Chris, Oostenbrink, Andrew, Murray, Todd R, Graham, Chad L, Myers, Brenda J, Andrews, Frederick P, Roth, Charles, Boone   +41 more
openaire   +2 more sources

Expressive suppression in psychosis: The association with social context.

PLoS ONE, 2020
As emotion regulation deficits have been implicated in psychotic disorders, it is imperative to investigate not only the effect of regulation strategies but also how they are used.
UnYoung Chavez-Baldini, Marieke Wichers, Ulrich Reininghaus, Johanna T W Wigman, Genetic Risk and Outcome of Psychosis Investigators   +4 more
doaj   +1 more source

Genetic analysis of the Replication Protein A large subunit family in Arabidopsis reveals unique and overlapping roles in DNA repair, meiosis and DNA replication [PDF]

, 2013
Replication Protein A (RPA) is a heterotrimeric protein complex that binds single-stranded DNA. In plants, multiple genes encode the three RPA subunits (RPA1, RPA2 and RPA3), including five RPA1-like genes in Arabidopsis.
Aklilu, Behailu B., Culligan, Kevin M., Soderquist, Ryan S.   +2 more
core   +5 more sources

Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy. [PDF]

, 2020
Developmental and epileptic encephalopathies are a heterogeneous group of early-onset epilepsy syndromes dramatically impairing neurodevelopment. Modern genomic technologies have revealed a number of monogenic origins and opened the door to therapeutic ...
Alix, E, Alkaya, DU, Ashrafzadeh, F, Becker, F, Bilguvar, K, Chatron, N, de Bellescize, J, EuroEpinomics-RES consortium AR working group, Gunes, N, Hardies, K, Hussien, H, Karimiani, EG, Kok, F, Labalme, A, Lerche, H, Lesca, G, Maroofian, R, May, P, Morsy, H, Moslemi, A-R, Nabil, A, Najafi, M, Omar, T, Poulat, A-L, Ramos, L, Roselli, S, Sanlaville, D, Schmidts, M, Tajsharghi, H, Tuysuz, B, Weckhuysen, S   +30 more
core   +2 more sources

Cell suppression problem: A genetic-based approach

Computers & Operations Research, 2008
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Almeida, Maria Teresa, Schutz, G., Carvalho, Filipa   +2 more
openaire   +3 more sources

Hypervariability, suppressed recombination and the genetics of individuality [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2004
We define ‘genetic individuality’ as intraspecies variation that has substantial heritability and involves traits that are sufficiently common that they can be observed in any modest–sized sampling of individuals. We propose that genetic individuality is largely shaped by the combinatory shuffling of a modest number of genes, each of which exists as a ...
M V, Olson, A, Kas, K, Bubb, R, Qui, E E, Smith, C K, Raymond, R, Kaul   +6 more
openaire   +2 more sources

Understanding protein–protein interactions by genetic suppression [PDF]

Journal of Genetics, 2000
Protein-protein interactions influence many cellular processes and it is increasingly being felt that even a weak and remote interplay between two subunits of a protein or between two proteins in a complex may govern the fate of a particular biochemical pathway.
Sujatha, Sitaraman, Chatterji, Dipankar
openaire   +3 more sources

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors. [PDF]

, 2020
Autophagy, particularly with BECN1, has paradoxically been highlighted as tumor promoting in Ras-driven cancers, but potentially tumor suppressing in breast and ovarian cancers.
Axelrod, Joshua, Bapat, Jaidev, Delaney, Joe R, DeStefano, John W, Haghighiabyaneh, Mina, Harismendy, Olivier, Jones, Christian M, La Spada, Albert R, Ortell, Katherine K, Patel, Chandni B, Ramos-Zapatero, Maria, Schlaepfer, David D, Stupack, Dwayne G, Tancioni, Isabelle, Tanios, Ralph   +14 more
core   +1 more source

Mechanisms of suppression: The wiring of genetic resilience [PDF]

BioEssays, 2017
Recent analysis of genome sequences has identified individuals that are healthy despite carrying severe disease‐associated mutations. A possible explanation is that these individuals carry a second genomic perturbation that can compensate for the detrimental effects of the disease allele, a phenomenon referred to as suppression.
Jolanda, van Leeuwen, Carles, Pons, Charles, Boone, Brenda J, Andrews   +3 more
openaire   +2 more sources

Wheat Genotype-Specific Recruitment of Rhizosphere Bacterial Microbiota Under Controlled Environments

Frontiers in Plant Science, 2021
Plants recruit beneficial microbial communities in the rhizosphere that are involved in a myriad of ecological services, such as improved soil quality, nutrient uptake, abiotic stress tolerance, and soil-borne disease suppression.
Christine Jade Dilla-Ermita, Ricky W. Lewis, Tarah S. Sullivan, Scot H. Hulbert, Scot H. Hulbert   +4 more
doaj   +1 more source