Results 31 to 40 of about 206,828 (247)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The clinicopathological analysis of ocular and orbit tumors in southeast of China

Frontiers in Oncology, 2023
PurposeThe purpose of this study is to describe the clinicopathologic characteristics of ocular surface and orbit tumors in the Southeast of China and explore the method to differentiate the benign and malignant masses.Materials and methods3468 patients ...
Yuan Lin, Yuan Lin, Xiaodong Liu, Xiaodong Liu, Yujie Zhang, Yujie Zhang, Zhiwen Xie, Zhiwen Xie, Xie Fang, Xie Fang, Ke Shi, Ke Shi, Yanlin Zhong, Yanlin Zhong, Shengqi Su, Shengqi Su, Shengqi Su, Minqing Cai, Minqing Cai, Huping Wu, Huping Wu, Shangkun Ou, Shangkun Ou   +22 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Global Deletion of Trp53 Reverts Ovarian Tumor Phenotype of the Germ Cell–Deficient White Spotting Variant (Wv) Mice

Neoplasia: An International Journal for Oncology Research, 2015
White spotting variant (Wv) mice are spontaneous mutants attributed to a point mutation in the c-Kit gene, which reduces the tyrosine kinase activity to around 1% and affects the development of melanocytes, mast cells, and germ cells.
Kathy Qi Cai, Ying Wang, Elizabeth R. Smith, Jennifer L. Smedberg, Dong-Hua Yang, Wan-Lin Yang, Xiang-Xi Xu   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Histopathological profile of ovarian tumors in a tertiary care centre and impact of recent WHO 2020 classification [PDF]

New Indian Journal of OBGYN
Background: Ovarian tumors are amongst the common neoplasms affecting the Indian women. The grave nature of these tumors is proved by the highest mortality rates attributed by lack of symptoms in most patients and inaccessible site.
Sheenam Azad, Neelima Bahal, Trisha Sharma, Nidhi Kumari, Seema Acharya   +4 more
doaj   +1 more source

Artificial intelligence-based analysis of time-lapse images of sphere formation and process of plate adhesion and spread of pancreatic cancer cells

Frontiers in Cell and Developmental Biology, 2023
Background: Most pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). Spherical morphology formed in three-dimensional (3D) cultures and the effects of anticancer drugs differ between epithelial and mesenchymal PDAC cell lines.
Yuuki Shichi, Fujiya Gomi, Yasuko Hasegawa, Keisuke Nonaka, Seiichi Shinji, Seiichi Shinji, Kimimasa Takahashi, Toshiyuki Ishiwata   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Histopathological spectrum of ovarian tumors in Jharkhand, India: A retrospective study

Journal of Family Medicine and Primary Care
Background: Ovarian tumors are the most prevalent neoplasms worldwide, affecting women of all ages. According to Globocan’s 2022 projections, by 2050, the number of women diagnosed with ovarian cancer worldwide will increase by over 55% to 503,448.
Manoj K. Paswan, Helen M. M. Tudu, Smita Kumari Gupta, Saurav Banerjee, Deepali Tirkey   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source