Results 101 to 110 of about 8,238,647 (329)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Numerical Implementation of a Critical State Model for Soft Rocks [PDF]

, 2018
This paper details the basic tasks for the numerical implementation of a simple elasto-plastic critical state model for bonded materials (i.e. soft rocks-hard soils) into the finite element program SNAC developed at the University of Newcastle in ...
Garitte B., Gens A., González N.A., González N.A., Leroueil S., Lloret-Cabot M., Lloret-Cabot M., Lloret-Cabot M., Pineda J.A., Sloan S.W.   +9 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Calibration of the hardening soil model in excalibre

Acta Polytechnica CTU Proceedings
The hardening soil model is one of the most commonly used constitutive models in engineering practice. This model is based on multi-surface plasticity and combines the well-known Mohr-Coulomb failure criterion, a hardening shear surface and a cap yield ...
Do Chinh Phuong, Tomáš Kadlíček, David Mašín, Jan Najser   +3 more
doaj   +1 more source

Surface hardening and finishing of metallic products by hybrid laser­ultrasonic treatment

, 2018
Theoretical and experimental study of the possibilities of using laser heat treatment (LHT) combined with ultrasonic impact treatment (UIT) for surface hardening and finishing of metallic products was carried out.
V. Dzhemelinskyi, D. Lesyk, O. Goncharuk, Oleksandr Dаnyleikо   +3 more
semanticscholar   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

COMPLEX SURFACE HARDENING OF STEEL ARTICLES

Литьë и металлургия, 2014
The method of complex surface hardening of steel detailswas designed. The method is a compound of two processes of hardening: chemical heat treatment and physical vapor deposition (PVD) of the coating.
A. V. Kovalchuk, S. V. Konstantinov, F. F. Komarov, G. A. Tkachenko   +3 more
doaj  

Electrofriction treatment of plow shares

Қарағанды университетінің хабаршысы. Физика сериясы
This paper presents the results of research aimed at developing the technology of plow share hardening by means of electrofriction hardening. It is shown that in electrofriction hardening of plow shares a structure with microhardness gradient is formed ...
Н.Е. Бердимуратов, Е.Е. Камбаров, М. Маулет, С.Д. Болатов, Ж.Б. Сагдолдина, Д.Р. Байжан   +5 more
doaj   +1 more source