Results 51 to 60 of about 1,012,835 (322)

Characterizing and Exploring the Differences in Dissolution and Stability Between Crystalline Solid Dispersion and Amorphous Solid Dispersion

AAPS PharmSciTech, 2020
Solid dispersion is one of the most effective ways to improve the dissolution of insoluble drugs. When the carrier can highly disperse the drug, it will increase the wettability of the drug and reduce the surface tension, thus improving the solubility ...
Xiaolin Wang, Lu Zhang, Danyang Ma, Xing Tang, Yu Zhang, Tian Yin, Jingxin Gou, Yanjiao Wang, Haibing He   +8 more
semanticscholar   +1 more source

Dynamics of viscous amphiphilic films supported by elastic solid substrates

, 1997
The dynamics of amphiphilic films deposited on a solid surface is analyzed for the case when shear oscillations of the solid surface are excited. The two cases of surface- and bulk shear waves are studied with film exposed to gas or to a liquid.
B Kasemo, Bechhoefer J, Blinov L M, Croxton C A, de Gennes P-G, Duncan-Hewitt W C, Earnshaw J C, Evans E A, Fragneto G, Helfrich W, Ivkov V G, Kanazawa K K, Kosevich A M, Kosevich Yu A, Kragel J, Landau L D, Landau L D, M Jonson, M V Voinova, McDermott D C, Mitchell D J, Plesski V P, Sauerbrey G, Sillerud L O, Uberall H, Voinova M V, Voinova M V   +26 more
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Clopidogrel Napadisilate Monohydrate Loaded Surface-Modified Solid Dispersion: Physicochemical Characterization and in Vivo Evaluation.

Biological and Pharmaceutical Bulletin, 2015
To develop a novel solid dispersion of clopidogrel napadisilate monohydrate (CNM) with improved stability and oral bioavailability, surface-modified solid dispersions were prepared by spray-drying using water as a solvent, Tween 80 as a surfactant, and ...
Young Hun Kim, Dong Wuk Kim, M. Kwon, K. Cho, Jong Oh Kim, C. Yong, Han‐Gon Choi   +6 more
semanticscholar   +1 more source

Introduction of Side Chains into Polyglycine Dispersed on Solid Surface. I [PDF]

Bulletin of the Chemical Society of Japan, 1956
Abstract 1) Polyglycine dispersed on the surface of kaolinite was prepared by the polycondensation of N-carboxylic anhydride or glycine ester on kaolinite. 2) It was concluded that a part of glycyl residues in polyglycine dispersed on kaolinite was easily converted to seryl or threonyl residues by the ...
Shiro Akabori, Kenji Okawa, Mikio Sato
openaire   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Ultrafast nonlinear optical response of Dirac fermions in graphene [PDF]

, 2018
The speed of solid-state electronic devices, determined by the temporal dynamics of charge carriers, could potentially reach unprecedented petahertz frequencies through direct manipulation by optical fields, consisting in a million-fold increase from ...
Baudisch, Matthias, Biegert, Jens, Cox, Joel D., García de Abajo, F. Javier, Koppens, Frank H. L., Levitov, Leonid S., Marini, Andrea, Massicotte, Mathieu, Silva, Francisco, Teichmann, Stephan, Zhu, Tony   +10 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

ENHANCED SOLUBILITY AND DISSOLUTION BY SURFACE-MODIFIED SOLID DISPERSION OF ALECTINIB HYDROCHLORIDE

International Journal of Applied Pharmaceutics, 2023
Objective: Alectinib hydrochloride (AH), a poorly soluble drug, exhibits low solubility thereby very low bioavailability. The present study aims to develop and optimize surface-modified solid dispersion of AH (AH-SMSD) with enhanced solubility and dissolution using Soluplus® (SOL) and Gelucire 44/14 (GEL) as a polymer and surfactant, respectively ...
SUMIT KUMAR SAHA, AMITA JOSHI, ROMI SINGH, KIRAN DUBEY   +3 more
openaire   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source