Results 71 to 80 of about 1,012,835 (322)

Development of Orodispersible Tablets with Solid Dispersions of Fenofibrate and Co-Processed Mesoporous Silica for Improved Dissolution

Pharmaceutics
Poor water solubility is an important challenge in the development of oral patient-friendly solid dosage forms. This study aimed to prepare orodispersible tablets with solid dispersions of a poorly water-soluble drug fenofibrate and a co-processed ...
Ana Baumgartner, Odon Planinšek
doaj   +1 more source

A mathematical model of metallized solid propellant combustion under the changing pressure

MATEC Web of Conferences, 2017
This paper presents the mathematical model describing a non-stationary combustion of metallized solid propellant. The model takes into account the heat transfer, the oxidizer decomposition and gasification of the solid propellant, two-phase, dual ...
Poryazov Vasily, Krainov Aleksei, Krainov Dmitry   +2 more
doaj   +1 more source

Effect of Ion-Plasma Nitriding on Phase Composition and Tensile Properties of AISI 321-Type Stainless Steel Produced by Wire-Feed Electron-Beam Additive Manufacturing

Metals, 2022
We study the effect of ion-plasma surface nitriding on the phase composition, microstructure, surface microhardness, and tensile properties of the AISI 321-type stainless steel produced by wire-feed electron-beam additive manufacturing (EBAM). Ion-plasma
Valentina Moskvina, Elena Astafurova, Sergey Astafurov, Kseniya Reunova, Marina Panchenko, Eugenii Melnikov, Eugeny Kolubaev   +6 more
doaj   +1 more source

Quantum hydrodynamics of electron gases

, 2011
Electron gases in metals are described as quantum charged Newtonian viscous fluids experiencing Ohmic Darcy friction on the solid lattice ions as well.
Slavchov, Radomir, Tsekov, Roumen
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Quantum Effects in the Acoustic Plasmons of Atomically-Thin Heterostructures [PDF]

, 2019
Recent advances in nanofabrication technology now enable unprecedented control over 2D heterostructures, in which single- or few-atom thick materials with synergetic opto-electronic properties can be combined to develop next-generation nanophotonic ...
Cox, Joel D., de Abajo, F. Javier García, Echarri, A. Rodríguez   +2 more
core   +2 more sources

Elucidation of Molecular Interactions Between Drug–Polymer in Amorphous Solid Dispersion by a Computational Approach Using Molecular Dynamics Simulations

Advances and Applications in Bioinformatics and Chemistry
Introduction Amorphous drug dispersion is frequently used to enhance the solubility and dissolution of poorly water-soluble drugs, thereby improving their oral bioavailability.
D. Aulifa, Adnan Al Shofwan, S. Megantara, Taufik Muhammad Fakih, Arif Budiman   +4 more
semanticscholar   +1 more source

Effect of Carrier Lipophilicity and Preparation Method on the Properties of Andrographolide–Solid Dispersion

Pharmaceutics, 2019
Solid dispersion (SD) is a useful approach to improve the dissolution rate and bioavailability of poorly water-soluble drugs. This work investigated the effects of carrier material lipophilicity and preparation method on the properties of andrographolide
Guowei Zhao, Qingyun Zeng, Shoude Zhang, Youquan Zhong, Changhao Wang, Yashao Chen, Liquan Ou, Zheng-gen Liao   +7 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source