Results 71 to 80 of about 807,388 (293)
International Journal of COPD, 2020 Balazs Antus,1,2 Csilla Paska,1 Imre Barta1 1Department of Pathophysiology, National Koranyi Institute of Pulmonology, Budapest H-1121, Hungary; 2Department of Pulmonology, National Koranyi Institute of Pulmonology, Budapest H-1121, HungaryCorrespondence:
Antus B, Paska C, Barta I
doaj
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
VaccinesThe capability of antibodies to neutralize different SARS-CoV-2 variants varies among individuals depending on the previous exposure to wild-type or Omicron-specific immunogens by mono- or bivalent vaccinations or infections.
David Niklas Springer +6 more
doaj +1 more source
Synthesis of knowledge on the effects of fire and fire surrogates on wildlife in US dry forests [PDF]
, 2009 Summary: Dry forests throughout the United States are fire-dependent ecosystems, and much attention has been given to restoring their ecological function.
Fontaine, J.B., Kennedy, P.L.
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Toxins, 2019 Enzyme-linked immunosorbent assay (ELISA) test kits have been widely used for the determination of mycotoxins in agricultural products and foods, however, this test uses toxin standards with high toxicity and carcinogenicity that seriously threaten human
Caixia Zhang +4 more
doaj +1 more source
On a novel approach for optimizing composite materials panel using surrogate models [PDF]
, 2011 This paper describes an optimization procedure to design thermoplastic composite panels under axial compressive load conditions. Minimum weight is the goal. The panel design is subject to buckling constraints.
Akcay-Perdahcioglu, D. +3 more
core +1 more source