Results 61 to 70 of about 25,673,599 (348)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Introduction to Survival Analysis in Practice
Machine Learning and Knowledge Extraction, 2019 The modeling of time to event data is an important topic with many applications in diverse areas. The collective of methods to analyze such data are called survival analysis, event history analysis or duration analysis.
F. Emmert-Streib, M. Dehmer
semanticscholar +1 more source
Martingales in Survival Analysis
, 2022 The paper traces the development of the use of martingale methods in survival analysis from the mid 1970s to the early 1990s. This development was initiated by Aalen’s Berkeley Ph.D.-thesis in 1975, progressed in the late 1970s and early 1980s through work on the estimation of Markov transition probabilities, non-parametric tests and Cox’s regression ...
Aalen, Odd O. +4 more
openaire +2 more sources
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Survival Analysis Part IV: Further concepts and methods in survival analysis [PDF]
British Journal of Cancer, 2003 Most analyses of survival data use primarily Kaplan-Meier plots, logrank tests and Cox models. We have described the rationale and interpretation of each method in previous papers of this series, but here we have sought to highlight some of their limitations. We have also suggested alternative methods that can be applied when either the data or a given
Clark, T +3 more
openaire +4 more sources
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Survival Analysis and Interpretation of Time-to-Event Data: The Tortoise and the Hare
Anesthesia and Analgesia, 2018 Survival analysis, or more generally, time-to-event analysis, refers to a set of methods for analyzing the length of time until the occurrence of a well-defined end point of interest.
P. Schober, T. Vetter
semanticscholar +1 more source
FEBS Letters, EarlyView.Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke +2 more
wiley +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 Background 8‐Oxo‐2′‐deoxyguanosine (8‐oxo‐2′‐dG) is a biomarker of oxidative DNA damage that is associated with cardiovascular disease and premature mortality in the general population.
Merlin C. Thomas +9 more
doaj +1 more source
Infectio, 2021 Objective: to describe the seven-year survival and predictors of mortality among people with HIV who were treated in the Colombian health system between 2011 and 2018.Methods: 64 039 people diagnosed with HIV in Colombia were included.
Nathaly Ramírez-García
doaj +1 more source