Results 31 to 40 of about 479 (110)

Advances of capillary electrophoresis enantioseparations in pharmaceutical analysis (2017–2020)

ELECTROPHORESIS, Volume 42, Issue 17-18, Page 1709-1725, September 2021., 2021
Abstract Capillary electrophoresis is a powerful technique for the analysis of polar chiral compounds and has been widely accepted for analytical enantioseparations of drug compounds in pharmaceuticals and biological media. In addition, many mechanistic studies have been conducted in an attempt to rationalize enantioseparations in combination with ...
Sulaiman Krait, Mari‐Luiza Konjaria, Gerhard K. E. Scriba   +2 more
wiley   +1 more source

The pipeline of new molecules and regimens against drug-resistant tuberculosis

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2021
The clinical development and regulatory approval of bedaquiline, delamanid and pretomanid over the last decade brought about significant progress in the management of drug-resistant tuberculosis, providing all-oral regimens with favorable safety profiles.
Todd A. Black, Ulrike K. Buchwald
doaj   +1 more source

MmpL3 Inhibition as a Promising Approach to Develop Novel Therapies against Tuberculosis: A Spotlight on SQ109, Clinical Studies, and Patents Literature

Biomedicines, 2022
Tuberculosis (TB) is accountable for considerable global morbidity and mortality. Effective TB therapy with multiple drugs completes in about six months.
Mohd. Imran, Mandeep Kumar Arora, Anurag Chaudhary, Shah Alam Khan, Mehnaz Kamal, Manal Mutlaq Alshammari, Raghad Mohammad Alharbi, Nuha Abdullah Althomali, Ibrahim Mohammed Alzimam, Abdullah Ayed Alshammari, Bashair Hamed Alharbi, Amer Alshengeti, Abdulmonem A. Alsaleh, Shayea A. Alqahtani, Ali A. Rabaan   +14 more
doaj   +1 more source

In vitro Antimicrobial Activity Comparison of Linezolid, Tedizolid, Sutezolid and Delpazolid Against Slowly Growing Mycobacteria Isolated in Beijing, China

Infection and Drug Resistance, 2021
Xia Yu,* Fengmin Huo,* Fen Wang,* Shu’an Wen, Guanglu Jiang, Yi Xue, Lingling Dong, Liping Zhao, Rui Zhu, Hairong Huang National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing ...
Yu X, Huo F, Wang F, Wen S, Jiang G, Xue Y, Dong L, Zhao L, Zhu R, Huang H   +9 more
doaj  

Application of metabolomics to drug discovery and understanding the mechanisms of action of medicinal plants with anti‐tuberculosis activity

Clinical and Translational Medicine, Volume 7, Issue 1, December 2018., 2018
AbstractHuman tuberculosis (TB) is amongst the oldest and deadliest human bacterial diseases that pose major health, social and economic burden at a global level. Current regimens for TB treatment are lengthy, expensive and ineffective to emerging drug resistant strains. Thus, there is an urgent need for identification and development of novel TB drugs
Naasson Tuyiringire, Deusdedit Tusubira, Jean‐Pierre Munyampundu, Casim Umba Tolo, Claude M. Muvunyi, Patrick Engeu Ogwang   +5 more
wiley   +1 more source

Design, synthesis and biological evaluation of indole and N-benzylated indole Mannich bases as potent antitubercular agents [PDF]

, 2022
Though effective medicines have been available for treating drug-susceptible tuberculosis infections, the chances go from bleak to null as we move from multidrug resistant (MDR) to extremely drug resistant (XDR) or totally drug resistant (TDR) disease ...
Kumar, M Murali Krishna; Pharmaceutical Chemistry Research Labs, AU College of Pharmaceutical Sciences, Andhra University, Visakahapatnam 530 003, India, Sangeetha, G P V ; Pharmaceutical Chemistry Research Labs, AU College of Pharmaceutical Sciences, Andhra University, Visakahapatnam 530 003, India, Namratha, J Risy ; Pharmaceutical Chemistry Research Labs, AU College of Pharmaceutical Sciences, Andhra University, Visakahapatnam 530 003, India, Nagasree, K Purna ; Department of Pharmaceutical Chemistry, Vignan Institute of Pharmaceutical Technology, Duvvada, Visakahapatnam 530 003, India   +3 more
core   +3 more sources

TB and HIV Therapeutics: Pharmacology Research Priorities

AIDS Research and Treatment, Volume 2012, Issue 1, 2012., 2012
An unprecedented number of investigational drugs are in the development pipeline for the treatment of tuberculosis. Among patients with tuberculosis, co‐infection with HIV is common, and concurrent treatment of tuberculosis and HIV is now the standard of care.
Kelly E. Dooley, Peter S. Kim, Sharon D. Williams, Richard Hafner, Gary Maartens   +4 more
wiley   +1 more source

Treatment-emergent ALT increases in sutezolid-treated subjects.

, 2014
Treatment-emergent ALT increases in sutezolid-treated subjects.
Amour Venter (551594), Darcy Paige (334958), Annette Silvia (334962), Yao Zhang (134381), Tong Zhu (8079), Paul Miller (71343), Rodney Dawson (101812), Jason Gobey (551595), Andreas H. Diacon (551597), Robert S. Wallis (286546), Sven O. Friedrich (551593), Craig Ellery (551596), Kathleen Eisenach (225003)   +12 more
core   +1 more source

Searching for Ideal Oxazolidinone for Treatment of Tuberculosis

Туберкулез и болезни лёгких
Oxazolidinones represent a promising class of drugs for treatment of multidrug-resistant tuberculosis (MDR-TB). Linezolid, the first representative of this class, is highly effective; however, its use is limited due to its toxicity (myelosuppression ...
A. I. Gayda, G. N. Mozhokina, E. R. Pereverzeva, M. I. Romanova, A. V. Abramchenko, A. G. Samoylova   +5 more
doaj   +1 more source

Facile Synthesis of Oxazolidinones as Potential Antibacterial Agents

ChemistryOpen, Volume 14, Issue 7, July 2025.
A microwave‐assisted method synthesizes novel oxazolidinone analogues via a proline‐initiated three‐component Mannich reaction and subsequent cyclization. The resulting analogues show antibacterial activity against M. smegmatis, with a minimum MIC of 8 mg/L, which is comparable to Rifampicin.
Secret P. Els, Kimberleigh B. Govender, Mxolisi K. Sokhela, Nilay Bhatt, Nakita Reddy, Hendrik G. Kruger, Per I. Arvidsson, Hendra Gunosewoyo, Thavendran Govender, Tricia Naicker   +9 more
wiley   +1 more source