Results 41 to 50 of about 479 (110)

A systematic efficacy analysis of tuberculosis treatment with BPaL‐containing regimens using a multiscale modeling approach

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 4, Page 673-685, April 2024.
Abstract Tuberculosis (TB) is a life‐threatening infectious disease. The standard treatment is up to 90% effective; however, it requires the administration of four antibiotics (isoniazid, rifampicin, pyrazinamide, and ethambutol [HRZE]) over long time periods.
Maral Budak, Laura E. Via, Danielle M. Weiner, Clifton E. Barry III, Pariksheet Nanda, Gabrielle Michael, Khisimuzi Mdluli, Denise Kirschner   +7 more
wiley   +1 more source

Predicted whole blood bactericidal activity of TMC207 (J, bedaquiline) 400 mg QD and 200 mg TIW, and PNU-100480 (U, sutezolid) 600 mg BID, singly and together.

, 2013
Predicted whole blood bactericidal activity of TMC207 (J, bedaquiline) 400 mg QD and 200 mg TIW, and PNU-100480 (U, sutezolid) 600 mg BID, singly and together.
Mark Mitton-Fry (334953), Darcy Paige (334958), Wesley Jakubiec (334951), Annette Silvia (334962), Paul F. Miller (334965), Lynn Ladutko (334955), Robert S. Wallis (286546), Sheldon Campbell (334956)   +7 more
core   +1 more source

Estimated generic prices for novel treatments for drug resistant tuberculosis [PDF]

, 2016
Background: Estimated annual incidence of MDR-TB is 480,000, representing 5% of TB incidence, but 20% of mortality. Multiple drugs have recently been developed or re-purposed for the treatment of MDR-TB.
Fortunak, J, Nytko, FE, Nytko, F, Cooke, GS, Khoo, S, Cooke, G, Gotham, D, Pozniak, A, Hill, A   +8 more
core   +1 more source

Explanation of the Formation of Complexes between Representatives of Oxazolidinones and HDAS-β-CD Using Molecular Modeling as a Complementary Technique to cEKC and NMR

, 2021
Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid.
Katarzyna Michalska, Wojciech Bocian, Elżbieta Bednarek   +2 more
core   +1 more source

In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis

, 2017
Oxazolidinones are promising candidates for the treatment of Mycobacterium tuberculosis infections. We isolated linezolid-resistant strains from H37Rv (Euro-American) and HN878 (East-Asian) strains; resistance frequencies were ...
Tanya Parish, Devon D. Dennison, Catherine D. Shelton, Matthew B. McNeil   +3 more
core   +1 more source

Antimicrobial Effect of Oxazolidinones and Its Synergistic Effect with Bedaquiline Against Mycobacterium abscessus Complex

Infection and Drug Resistance, 2023
Tianhui Gao,1,* Cong Yao,1,* Yuanyuan Shang,1 Renchun Su,1 Xuxia Zhang,1 Weicong Ren,1 Shanshan Li,1 Wei Shu,2 Yu Pang,1 Qi Li2 1Department of Bacteriology and Immunology, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing ...
Gao T, Yao C, Shang Y, Su R, Zhang X, Ren W, Li S, Shu W, Pang Y, Li Q   +9 more
doaj  

Gold Nanoclusters Synthesized within Single-Chain Nanoparticles as Catalytic Nanoreactors in Water. [PDF]

Polymers (Basel)
This article belongs to the Section Polymer Chemistry.Metalloenzymes are able to catalyze complex biochemical reactions in cellular (aqueous) media with high efficiency.
Pinacho-Olaciregui J, Verde-Sesto E, Taton D, Pomposo JA.   +3 more
europepmc   +2 more sources

In Vitro Activities of Miltefosine and Antibacterial Agents from the Macrolide, Oxazolidinone, and Pleuromutilin Classes against Pythium insidiosum and Pythium aphanidermatum

, 2018
We tested 29 isolates of Pythium insidiosum and one isolate of Pythium aphanidermatum to investigate their susceptibility to miltefosine and antibacterial drugs from the macrolide, oxazolidinone, and ...
Erico S. Loreto, Sydney H. Alves, Juliana S. M. Tondolo, Janio M. Santurio, Daniele C. Oliveira   +4 more
core   +1 more source

Population Pharmacokinetics of AZD-5847 in Adults with Pulmonary Tuberculosis

, 2017
AZD-5847 is a new oxazolidinone derivative under development for the treatment of tuberculosis (TB). Here we describe the population pharmacokinetics (PK) of AZD-5847 in patients with tuberculosis based on a recently completed phase II study.
Elana van Brakel, Sara A. Debanne, Andreas H. Diacon, Abdullah Alsultan, Jennifer J. Furin, Jeannine Du Bois, Amour Venter, W. Henry Boom, Charles A. Peloquin, Bonnie Thiel, John L. Johnson, Phalkun Chheng   +11 more
core   +1 more source

Activity of MMV Pandemic Response Box compounds against Mycobacterium ulcerans viability and mycolactone production

Microbiology Spectrum
Mycobacterium ulcerans causes Buruli ulcer (BU), a skin neglected tropical disease, largely through the expression of a potent cytotoxin known as mycolactone.
Louisa Warryn, Daniel H. Paris
doaj   +1 more source